CAS: 945976-43-2

LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.

(2S)-2-Amino-3-(4-(2-Amino-6-(2,2,2-Trifluoro-1-(3'-Fluoro-[1,1'-Biphenyl]-4-Yl)Ethoxy)Pyrimidin-4-Yl)Phenyl)Propanoic Acid

LP 533401 is a small molecule compound, which functions as a selective antagonist of the lysophosphatidic acid receptor 1 (LPA1). This compound is derived through synthetic chemical processes designed to interact specifically with the G protein-coupled receptor LPA1. By competitively inhibiting the binding of lysophosphatidic acid (LPA) to LPA1, LP 533401 effectively alters downstream signaling pathways. The mode of action of LP 533401 involves modulation of signal transduction processes that are typically mediated by the interaction of LPA with its receptor. Through receptor antagonism, LP 533401 reduces the biological effects associated with LPA1 activation, which includes processes such as cell migration, proliferation, and survival. In terms of applications, LP 533401 is being investigated for its therapeutic potential in conditions where LPA signaling plays a crucial role, such as fibrosis, cancer, and neuropathic pain. The compound is of particular interest for its ability to modulate the fibrotic response, suggesting its utility in the treatment of fibrotic diseases. Given the complexity and involvement of LPA receptors in various pathophysiological processes, LP 533401 represents a significant tool for probing the role of LPA1 in disease development and progression.