CAS 95-65-8: 3,4-Dimethylphenol

3,4-Dimethylphenol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3,4-Xylenol is a cytosolic calcium ionophore that has been shown to induce apoptosis in human erythrocytes and hk-2 cells. The cytosolic Ca++ concentration was found to rise rapidly after 3,4-xylenol treatment. This increase was dependent on the concentration of extracellular Ca++. The linear calibration curve for 3,4-xylenol showed a good correlation with the data obtained from kinetic analysis. 3,4-Xylenol is a chemical compound that can be synthesized from xylene and ethanol in the presence of ultraviolet light or by catalytic hydrogenation of acetaldehyde. The product can be purified by gravimetric analysis or by an analytical method such as gas chromatography. 3,4-Xylenol has been shown to react with free hydroxyl groups to form a cyclic adduct that is unstable and undergoes spontaneous decomposition into hydroxylamine

Applications 3,4-Dimethylphenol-13C8 is the isotope labelled analog of 3,4-Dimethylphenol. 3,4-Dimethylphenol is a reagent in the synthesis of vialinin A analogs with a potent inhibitory activity of tumor necrosis factor-a production. References Ye, Y.Q., et al.: Bioorg. Med. Chem. Lett., 22, 2385 (2012);