L-Threonine, N-methyl-, methyl ester, identified by the CAS number 95599-23-8, is a derivative of the amino acid threonine. This compound features a methyl group attached to the nitrogen of the threonine backbone, along with a methyl ester functional group. It is characterized by its polar nature due to the presence of hydroxyl and amino groups, which can engage in hydrogen bonding. This compound is typically soluble in polar solvents such as water and methanol, making it useful in various biochemical applications. L-Threonine is essential for protein synthesis and plays a role in various metabolic processes. The methylation of the amino group can influence its biological activity and interactions with enzymes and receptors. As a methyl ester, it may exhibit different properties compared to its parent amino acid, including altered solubility and reactivity. Overall, L-Threonine, N-methyl-, methyl ester is of interest in fields such as biochemistry, pharmaceuticals, and nutrition, particularly in studies related to amino acid metabolism and protein engineering.

L-Threonine, N-methyl-, methyl ester

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N-Me-Thr-OMe·HCl is an analogue of the drug deglycobleomycin. It has a high selectivity for DNA cleavage, which abolishes inherent resistance to bleomycin. N-Me-Thr-OMe·HCl also has structural and efficiency advantages over other analogues. This drug has been shown to be effective in treating leukemia and lymphoma, where it prevents the synthesis of DNA and RNA by inhibiting dna cleavage. The hydrogen bond between l-threonine and threonine is essential for the formation of this drug. The epimerization of l-threonine to dl-threonine is essential for the synthesis of this drug.

CAS 95599-23-8: L-Threonine, N-methyl-, methyl ester

N-Me-Thr-OMe·HCl

Ref: 3D-FM72768

(2S,3R)-methyl 3-hydroxy-2-(methylamino)butanoate

Ref: IN-DA01E66L