CAS 956-92-3: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-

Chlorthalidone is a drug product that contains the impurity J. Chlorthalidone is an antihypertensive drug that belongs to the class of thiazides. It is used in the treatment of hypertension, congestive heart failure, and edema. Chlorthalidone is metabolized by the liver and eliminated through urine; it has been shown to be excreted unchanged in urine as well as in bile. The impurity J can be found in human urine, which may be due to metabolism by microorganisms or renal clearance.

Lactams, nesoi

Applications 3-(p-Chlorophenyl)-3-hydroxyphthalimidine is an analog of Chlorthalidone (C427500) and has potential antidiuretic and hyperglycemic activities. References Wales, J.K., et al.: P. Soc. Exp. Biol. Med., 128, 581 (1968)