CAS: 95853-92-2

CGS 15435

CGS 15435 is a synthetic compound that functions as a dopamine receptor agonist, derived from chemical synthesis processes involving targeted modifications of organic compounds. It exhibits high affinity and selectivity toward specific subtypes of dopamine receptors, which are G-protein-coupled receptors critical to neurotransmission in the central nervous system. The primary mode of action of CGS 15435 involves binding to dopamine receptors, particularly influencing dopaminergic pathways. This agonistic activity can modulate neuronal excitability and synaptic transmission, making it a powerful tool for dissecting the complexities of dopamine-mediated signaling. In terms of its applications, CGS 15435 is predominantly employed in neuropharmacological research. It is instrumental in studying the physiological and pathological roles of dopamine in neuropsychiatric and neurodegenerative disorders. Researchers leverage this compound to investigate the mechanisms underlying diseases such as Parkinson's disease and schizophrenia, as well as to explore potential therapeutic targets within the dopaminergic system. Through these studies, CGS 15435 contributes to a deeper understanding of dopamine's role in brain function and dysfunction.

CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.