CAS: 959019-05-7

2-Chloro-5-fluoropyrazine is a chemical compound that is used as an intermediate in the synthesis of other compounds. It is a synthetic intermediate that can be prepared by the amination of chloral with trifluoromethoxybenzene. The coupling reaction between 2-chloro-5-fluoropyrazine and various electrophiles has been shown to be efficient. This molecule can also be synthesized by reacting pyrazines with chlorine gas in the presence of catalysts such as palladium or nickel. 2-Chloro-5-fluoropyrazine has been used in Buchwald-Hartwig aminations, which are a scalable method for the synthesis of heterocycles.

2-Chloro-5-fluoropyrazine