CAS 96203-70-2: (+)-Pancratistatin

Stability Hygroscopic Applications Pancratistatin acts as an anti-cancer compound that initiates cell-death in cancer cells. References McLachlan, A. et al.: Apoptosis, 10, 619 (2005);

Pancratistatin is a naturally-derived alkaloid, primarily isolated from the bulbs of the Pancratium littorale and other members of the Amaryllidaceae family. It exerts its biological activity through the selective induction of apoptosis in cancer cells while sparing normal cells. This remarkable selectivity is likely due to the compound’s ability to target mitochondrial pathways, disrupting the cancer cell's energy metabolism and triggering cell death without affecting healthy tissue. The compound has garnered interest for its potential applications in cancer research and therapy. Its ability to induce apoptosis specifically in cancer cells makes it an attractive candidate for developing targeted anticancer drugs. Current research focuses on understanding the detailed mechanisms underlying its selectivity and efficacy, as well as exploring its combination with other therapeutic agents to enhance anticancer effects. While still in the research and development phase, Pancratistatin’s unique properties hold promise for contributing to the next generation of cancer treatments.

Pancratistatin, an isoquinoline from Hymenocallis littoralis, triggers apoptosis in melanoma and is studied for neuroblastoma, leukemia, and breast cancer.