CAS 96304-42-6: Trypanothione
Formula:C27H47N9O10S2
InChI:InChI=1S/C27H47N9O10S2/c28-16(26(43)44)4-6-20(37)35-18-14-47-48-15-19(36-21(38)7-5-17(29)27(45)46)25(42)34-13-23(40)32-11-3-9-30-8-1-2-10-31-22(39)12-33-24(18)41/h16-19,30H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46)/t16-,17-,18-,19-/m0/s1
InChI key:InChIKey=LZMSXDHGHZKXJD-VJANTYMQSA-N
SMILES:N(C(CC[C@@H](C(O)=O)N)=O)[C@@H]1C(=O)NCC(=O)NCCCCNCCCNC(=O)CNC(=O)[C@@H](NC(CC[C@@H](C(O)=O)N)=O)CSSC1
Synonyms:- Glycinamide, L-γ-glutamyl-L-cysteinyl-N-[3-[[4-[[N-(N-L-γ-glutamyl-L-cysteinyl)glycyl]amino]butyl]amino]propyl]-, cyclic (2→3)-disulfide
- Glycinamide, L-γ-glutamyl-L-cysteinyl-N-[3-[[4-[(L-γ-glutamyl-L-cysteinylglycyl)amino]butyl]amino]propyl]-, cyclic (2→2′)-disulfide
- 1,2-Dithia-6,9,13,18,21-pentaazacyclotetracosane, cyclic peptide deriv.
- Trypanothione
- Trypanothione disulfide
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Found 4 products.
Trypanothione N1,N8-Bis(glutathionyl)-spermidine disulfide
CAS:Trypanothione N1,N8-Bis(glutathionyl)-spermidine disulfide is a reactive oxygen species (ROS) scavenger that is produced by the enzyme glutathione reductase and has been shown to be effective against the protozoan leishmania. The reactivity of this molecule is due to its disulfide bond. This reactive cysteine residue can undergo a redox reaction with ROS, which causes cell lysis and leads to the death of the parasite. Trypanothione N1,N8-Bis(glutathionyl)-spermidine disulfide has been shown to have anti-inflammatory properties in mice, which may be due to its ability to inhibit prostaglandin synthesis. It also has been shown to inhibit the production of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α).Formula:C27H47N9O10S2Purity:Min. 95%Molecular weight:721.85 g/molTrypanothione
CAS:Trypanothione (TS2) was purified from the insect trypanosomatid Crithidia fasciculata and identified as a covalently linked adduct of glutathione and spermidine. TS2 is utilized as a substrate by trypanothione reductase, a unique enzyme found in trypanosomes and leishmanias (Km = 51 µM).Formula:C27H47N9O10S2Purity:98.0%Color and Shape:White PowderMolecular weight:721.86Trypanothione
CAS:Trypanothione, a bis-glutathionyl derivative present in trypanosomatids, offers protection against oxidative stress [1] [2] [3].Formula:C27H47N9O10S2Color and Shape:SolidMolecular weight:721.85
