dUMP, or deoxyuridine monophosphate, is a nucleotide that plays a crucial role in the synthesis of DNA. It is a pyrimidine nucleotide, consisting of a deoxyribose sugar, a uracil base, and a single phosphate group. The chemical formula for dUMP is C9H11N2O4P. One of its key characteristics is its involvement in the thymidylate synthesis pathway, where it is converted to deoxythymidine monophosphate (dTMP) by the enzyme thymidylate synthase, a process that is essential for DNA replication and repair. dUMP is also a substrate for various biochemical reactions and can be phosphorylated to form dUDP and dUTP. In terms of stability, dUMP is relatively stable under physiological conditions but can be hydrolyzed under extreme pH or temperature. Its CAS number, 964-26-1, is a unique identifier that facilitates the identification and study of this compound in scientific literature and databases. Overall, dUMP is a vital component in cellular metabolism and genetic material synthesis.

dUMP

964-26-1: 1-(2-deoxy-5-O-phosphonopentofuranosyl)pyrimidine-2,4(1H,3H)-dione, 2'-Deoxy-5'-uridylic acid, 2'-Deoxyuridine 5'-monophosphate, 2'-Deoxyuridine 5'-phosphate, 2'-Deoxyuridylate, 2'-Deoxyuridylic acid, 2′-Deoxy-5′-UMP, 5'-Uridylic acid, 2'-deoxy-, Brn 0042143, Deoxy-UMP, Deoxyuridine 5'-monophosphate, Deoxyuridine 5'-phosphate, Deoxyuridine monophosphate, Deoxyuridylic acid, Uridine, 2'-deoxy-, 5'-(dihydrogen phosphate), Uridine, 2'-deoxy-, 5'-phosphate, dUMP,  4-24-00-01200 (Beilstein Handbook Reference)

2'-Deoxyuridine-5'-monophosphate free acid is a nucleotide that is found in biological samples. It has been shown to have high values for x-ray crystallography and hyperproliferative disease. 2'-Deoxyuridine-5'-monophosphate free acid inhibits the activity of DNA polymerase, which may be due to its ability to act as a competitive inhibitor of thymidylate synthase. This nucleotide also has potential as a drug target because it inhibits the growth of cells infected with fungi and bacteria. 2'-Deoxyuridine-5'-monophosphate free acid prevents bacterial and fungal replication by blocking DNA synthesis through inhibition of the enzyme thymidylate synthetase.

CAS 964-26-1: dUMP

2'-Deoxyuridine-5'-monophosphate free acid

Ref: 3D-ND153405