L-Histidine, L-isoleucyl- is a dipeptide composed of the amino acids L-histidine and L-isoleucine. It is characterized by its structure, which includes an imidazole side chain from histidine, contributing to its role in enzyme catalysis and metal ion binding. The presence of isoleucine, a hydrophobic amino acid, influences the peptide's overall hydrophobicity and stability. This dipeptide is typically soluble in water due to the polar nature of its constituent amino acids, making it relevant in biological systems. L-Histidine is essential for various physiological functions, including the synthesis of histamine and the maintenance of pH balance in tissues, while isoleucine plays a critical role in muscle metabolism and energy production. The CAS number 97284-12-3 uniquely identifies this compound, facilitating its recognition in scientific literature and databases. Overall, L-Histidine, L-isoleucyl- exhibits properties that are significant in biochemistry and nutrition, particularly in protein synthesis and metabolic pathways.

L-Histidine, L-isoleucyl-

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H-Ile-His-OH

H-Ile-His-OH is a peptide that has been found to be an antagonist of the epidermal growth factor receptor. It has been shown to decrease inflammation in animal models of bowel disease and may be useful in the treatment of inflammatory bowel disease. H-Ile-His-OH has also been shown to inhibit the production of inflammatory cytokines such as IL-1β, IL-6, and TNF α. This peptide also inhibits monoclonal antibody production by dendritic cells and can prevent resistant mutants from developing. H-Ile-His-OH is a potent antagonist of Toll-Like Receptor (TLR) 4, TLR2, TLR3, and TLR9. H-Ile-His-OH is currently being investigated for its possible role in the treatment of infectious diseases and autoimmune diseases.

CAS 97284-12-3: L-Histidine, L-isoleucyl-

H-Ile-His-OH

Ref: 01-4000894

H-Ile-His-OH

Ref: 3D-FI108076