CAS 97315-18-9: Benzaldehyde, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy-

3-tert-Butyldimethylsiloxy-4-methoxybenzaldehyde (BMS) is a cytotoxic compound that is used as an anticancer agent. BMS is a methoxylated aromatic compound and can be metabolized in vitro to produce a variety of metabolic products, including the d1 and d2 stereoisomers. It has been shown that the d1 form of BMS is more cytotoxic than the d2 form. The cellular localization of BMS has been demonstrated using immunostaining on MCF-7 cells. It has also been shown that BMS causes apoptosis in MCF-7 cells, which may be due to its ability to induce caspase activation and inhibit cell proliferation.

Applications Intermediate in the production of anticancer/antitumor stilbene derivatives. References Simoni, D., et al.: J. Med. Chem., 51, 6211 (2008), Tanpure, R., et al.: Bioorg. Med. Chem., 17, 6993 (2009), Alvarez, R., et al.: Bioorg. Med. Chem., 17, 6422 (2009),