CAS 97399-91-2: Aristololactam A IIIa

Aristolactam AIIIA is an alkaloid, which is a naturally occurring compound derived from plants in the Aristolochiaceae family. This compound exhibits a unique structure that consists of a lactam ring, characteristic of its class. The mode of action of Aristolactam AIIIA is thought to involve interaction with DNA topoisomerases, enzymes crucial for DNA replication and cell division. This interaction suggests that Aristolactam AIIIA could interfere with these cellular processes, making it a candidate for exploration in anticancer and antimicrobial research. The potential applications of Aristolactam AIIIA are significant in the field of pharmacology. Its ability to modulate enzyme activity presents possibilities for developing new therapeutic agents, particularly in the fight against cancer and various infectious diseases. Additionally, its natural origin underscores the importance of biodiversity and plant-based compounds in drug discovery, offering insights into new molecular frameworks for drug development. As a subject of ongoing research, Aristolactam AIIIA continues to intrigue scientists interested in its bioactivity and therapeutic potential.

Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity.