CAS 97420-39-8: 1H-Benzimidazole-1-aceticacid, hydrazide

2-(1H-Benzimidazol-1-yl)acetohydrazide is an antibacterial agent that has been shown to have a hydrophobic structure and act as a competitive inhibitor of bacterial acetohydroxy acid synthase. This agent binds to the enzyme, inhibiting the formation of beta-ketoacyl-ACP. 2-(1H-Benzimidazol-1-yl)acetohydrazide is active against corynebacterium and other bacteria. The chemical structure of this compound is similar to that of benzoxazinone, which is also an effective antibacterial agent. The difference between these two compounds is that 2-(1H-Benzimidazol-1-yl)acetohydrazide does not form hydrogen bonds with its acceptor groups in the substrate binding site. The geometric isomers are also different, with one being more active than the other.