CAS 98-81-7: α-Bromostyrene

Applications (1-Bromoethenyl)-benzene is a useful synthetic intermediate. It is a reactant used to synthesize Potassium (1-Phenylcyclopropyl)trifluoroborate (P698400). It can also be used in the synthesis of substituted cyclopentenones. References Zhang, L., et al.: J. Am. Chem. Soc., 128, 1442 (2006)

?-Bromostyrene

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Alpha-bromostyrene is a reactive chemical intermediate used in the synthesis of alpha-methylstyrene. It can be obtained by reacting 2-bromostyrene with hydrogen chloride in the presence of palladium and an organic solution such as tetrahydrofuran. The cross-coupling reaction mechanism is believed to involve generation of a reactive carbonium ion that reacts with the bromide to form an aryl chloride intermediate, which can then react with amines or other electrophiles to generate products.