CAS: 99095-10-0

Tandospirone (SM-3997) HCl: potent 5-HT1A partial agonist; Ki: 27 nM; anxiolytic, antidepressant, for CNS disorder research.

Tandospirone hydrochloride is a selective agonist of the 5-HT1A serotonin receptor, which is synthesized through a chemical process involving the modification of pyrimidinylpiperazine derivatives. Its primary mode of action involves partial agonism at the 5-HT1A receptors in the central nervous system, which helps modulate neurotransmission by inhibiting serotonin release. This action is thought to alleviate anxiety symptoms by normalizing serotonin levels in the brain. Tandospirone hydrochloride is primarily utilized in the clinical management of anxiety disorders, including generalized anxiety disorder and panic disorder. It has also been explored for its potential benefits in treating depression and certain psychosomatic conditions due to its anxiolytic properties. Researchers are particularly interested in its mechanism, as it offers an alternative to traditional benzodiazepines, potentially with fewer sedative effects and lower risk of dependence. Tandospirone's pharmacological profile makes it a subject of ongoing study for expanding its therapeutic applications and understanding its long-term effects on mood regulation.