CAS: 99112-24-0

Bz-Arg-Gly-Phe-Phe-Leu-4MbetaNA is a fluorophosphate synthetic substrate that has been shown to be hydrolyzed. It also denatures, and the acidic side chain of Bz is responsible for this activity. The Leishmania parasite is sensitive to Bz-Arg-Gly-Phe-Phe-Leu-4MbetaNA. This substrate is hydrophobic and binds to the active site of aspartyl proteases, which are enzymes that cleave peptide bonds in proteins. This substrate may be used as an experimental tool for studying the conformations of polypeptides in solution and how they are cleaved by proteolytic enzymes.

Bz-RGFFL-MNA, substrate for cathepsin D.