4-Fluoro-1-[1-(thiophen-2-yl)cyclohexyl]piperidine, identified by its CAS number 99486-47-2, is a synthetic compound that belongs to the class of piperidine derivatives. This substance features a piperidine ring substituted with a cyclohexyl group and a thiophene moiety, along with a fluorine atom at the 4-position of the piperidine ring. The presence of the thiophene ring contributes to its potential biological activity, as thiophenes are known for their diverse pharmacological properties. The fluorine atom can enhance the compound's lipophilicity and metabolic stability, which may influence its interaction with biological targets. This compound is of interest in medicinal chemistry and drug development, particularly in the context of neuropharmacology, due to its structural similarities to other psychoactive substances. However, detailed studies on its pharmacodynamics, pharmacokinetics, and safety profile are essential for understanding its potential applications and effects. As with any chemical substance, proper handling and safety protocols should be observed during its use and study.

4-fluoro-1-[1-(thiophen-2-yl)cyclohexyl]piperidine

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Fluoxetine is a selective serotonin reuptake inhibitor that has been used clinically to treat depression. This drug inhibits the reuptake of serotonin, which leads to an increase in the concentration of serotonin in the synaptic cleft and an enhancement of serotonergic neurotransmission. Fluoxetine has been shown to be effective at treating insulin resistance and obesity in clinical studies. The linear calibration curve for fluoxetine was found using confocal microscopy and sequence analysis on human adipose tissue. Fluoxetine treatment increased insulin sensitivity and decreased food intake in rats with metabolic syndrome. Logistic regression was used to establish statistical significance between fluoxetine treatment and weight loss as well as insulin sensitivity. Fluoxetine was also found to increase the mitochondrial membrane potential through regulation of voltage-dependent anion channels, leading to antidepressant activity.

CAS 99486-47-2: 4-fluoro-1-[1-(thiophen-2-yl)cyclohexyl]piperidine

4-Fluoro-1-(1-(2-Thienyl)Cyclohexyl)Piperidine

Ref: 3D-FF89814