CAS 99533-80-9: (+)-K 252a
Formula:C27H21N3O5
InChI:InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key:InChIKey=KOZFSFOOLUUIGY-SOLYNIJKSA-N
SMILES:C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@]2(C(OC)=O)O)[H])=CC=CC8
Synonyms:- (+)-K 252a
- 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-
- 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-
- 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)-
- 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, [9S-(9α,10β,12α)]-
- Antibiotic K 252a
- Antibiotic SF 2370
- K 252
- K 252a Nocardiopsis sp.
- K252a
- Protein kinase inhibitor K252a
- See more synonyms
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Found 8 products.
K-252a
CAS:Formula:C27H21N3O5Purity:100.0%Color and Shape:Yellowish amorphous solidMolecular weight:467.0K252a
CAS:Inhibitor of TRK family of kinasesFormula:C27H21N3O5Purity:Min. 95%Molecular weight:467.47 g/molK252a
CAS:K252aFormula:C27H21N3O5Purity:By hplc: 99.23% (Typical Value in Batch COA)Color and Shape: white powderMolecular weight:467.47g/molK252a
CAS:Controlled ProductApplications K252a is a protein kinase inhibitor. It is an analogue of staurosporine (S685000). It shows potent antitumor activity but no antimicrobial activity in vitro, or in vivo toxicity in rodents. References Kase, H., et al.: J. Antibiot., 39, 1059 (1986); Yasuzawa, T., et al.; J. Antibiot., 39, 1072 (1986)Formula:C27H21N3O5Color and Shape:NeatMolecular weight:467.47K-252a
CAS:Formula:C27H21N3O5Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:467.47K-252A
CAS:K-252A is an antimicrobial agent that inhibits the growth of bacteria. It binds to the response element in the promoter region of genes and blocks gene transcription, thereby preventing protein synthesis. K-252A has been shown to inhibit the growth of bacteria that are resistant to many other antibiotics, including ampicillin, chloramphenicol, clindamycin, erythromycin, gentamicin and kanamycin. This drug also induces significant up-regulation of cyclic nucleotide phosphodiesterases (PDE) and cytosolic Ca2+ in vitro. K-252A has been shown to cause neuronal death in vitro by inhibiting axonal growth. K-252A also inhibits leukemia inhibitory factor (LIF) from binding to its receptor on mouse lymphocytes.Formula:C27H21N3O5Purity:Min. 95%Molecular weight:467.49 g/mol
