CAS 99534-03-9: protein kinase inhibitor rabbit*sequence
Formula:C94H148N32O31
InChI:InChI=1/C94H148N32O31/c1-11-42(3)70(124-85(150)58(31-50-19-14-13-15-20-50)117-84(149)61(35-67(135)136)116-74(139)44(5)110-81(146)57(32-51-24-26-53(131)27-25-51)119-90(155)73(49(10)130)126-86(151)69(96)47(8)128)88(153)112-45(6)75(140)122-63(40-127)77(142)107-38-65(133)114-55(22-17-29-105-93(99)100)80(145)125-72(48(9)129)87(152)108-39-66(134)113-54(21-16-28-104-92(97)98)78(143)115-56(23-18-30-106-94(101)102)79(144)118-60(34-64(95)132)82(147)111-46(7)76(141)123-71(43(4)12-2)89(154)120-59(33-52-37-103-41-109-52)83(148)121-62(91(156)157)36-68(137)138/h13-15,19-20,24-27,37,41-49,54-63,69-73,127-131H,11-12,16-18,21-23,28-36,38-40,96H2,1-10H3,(H2,95,132)(H,103,109)(H,107,142)(H,108,152)(H,110,146)(H,111,147)(H,112,153)(H,113,134)(H,114,133)(H,115,143)(H,116,139)(H,117,149)(H,118,144)(H,119,155)(H,120,154)(H,121,148)(H,122,140)(H,123,141)(H,124,150)(H,125,145)(H,126,151)(H,135,136)(H,137,138)(H,156,157)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)
SMILES:CCC(C)C(C(=NC(C)C(=NC(CO)C(=NCC(=NC(CCCNC(=N)N)C(=NC(C(C)O)C(=NCC(=NC(CCCNC(=N)N)C(=NC(CCCNC(=N)N)C(=NC(CC(=N)O)C(=NC(C)C(=NC(C(C)CC)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=O)O)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(Cc1ccccc1)N=C(C(CC(=O)O)N=C(C(C)N=C(C(Cc1ccc(cc1)O)N=C(C(C(C)O)N=C(C(C(C)O)N)O)O)O)O)O)O
Synonyms:- Protein Kinase A Inhibitor 5-24
- H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
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Found 5 products.
PKI (5-24)
CAS:PKI (5-24) is a synthetic peptide specifically designed as a protein kinase inhibitor. Derived from a segment of the endogenous PKA inhibitor protein, this peptide is utilized to inhibit the activity of cyclic AMP-dependent protein kinase (PKA). The sequence corresponds to amino acids 5-24 of the native protein, retaining its potent inhibitory activity. PKI (5-24) functions by binding to the catalytic subunit of PKA, thus preventing the phosphorylation of downstream targets. In research settings, PKI (5-24) is applied to study PKA signaling pathways, ascertain the role of PKA in various cellular processes, and elucidate the impacts of PKA inhibition in different physiological contexts. It is particularly valuable in investigations into signal transduction, cell metabolism, and neurobiology, providing insights into mechanisms underlying disorders such as cancer and cardiovascular diseases. As an established tool in molecular biology and biochemistry, PKI (5-24) enables targeted modulation of kinase activity, thereby facilitating precise investigation of cellular signaling pathways.Formula:C94H148N32O31Purity:Min. 95%Molecular weight:2,222.4 g/molPKI(5-24)
CAS:High affinity PKA inhibitor (Ki = 2.3 nM).Formula:C76H129N31O28Purity:98%Color and Shape:SolidMolecular weight:1925.057cAMP Dependent Protein Kinase Inhibitor (PKI 5-24)
CAS:cAMP Dependent Protein Kinase Inhibitor (PKI 5-24) acts as inhibitor of c-AMP-dependent protein kinase These proteins bind to the catalytic subunit of cyclic-AMP dependent protein kinase, displacing the regulatory subunit and inhibiting phosphorylating activity. The cyclic-AMP binding capacity of the regulatory subunit is enhanced. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C94H148N32O31Molecular weight:2222.4
