CAS 99896-85-2: Arginine-glycine-aspartic acid

The target epitope of several integrin receptors is the RGD sequence, a cell adhesion motif shared by several matrix-associated adhesive glycoproteins, such as fibronectin, vitronectin, fibrinogen, collagen type I, laminin, and von Willebrand factor.

Arginine-glycine-aspartic acid

RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.

Arg-Gly-Asp is a peptide with inhibitory properties against tumor growth. It binds to the integrin receptor and blocks the angiogenic process by inhibiting the expression of vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-β). Arg-Gly-Asp also inhibits the proliferation of pluripotent cells, which are cells that can differentiate into any type of cell in the body, and prevents the formation of new blood vessels. This peptide has been shown to have inhibitory properties against leukemia inhibitory factor (LIF), which is a cytokine that regulates cell growth.

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Fragment from cell-attachment domain of fibronectin; a cell-attachment peptide This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.