Amino Acid Derivatives

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Fmoc-His(Trt)-OH is an amino acid with the chemical formula HOOC-CH2-CH2-N(CH3)2. It has broad-spectrum antimicrobial activity and can be used as a chemosensor for trifluoroacetic acid. Fmoc-His(Trt)-OH also showed anticancer activity, which may be due to its ability to inhibit protein synthesis in cancer cells by inhibiting histidine decarboxylase. Fmoc-His(Trt)-OH is synthesized through a chemical reaction using trifluoroacetic acid, which reacts with His and Trt residues on the surface of the resin.

Cyclo(His-Pro), a diketopiperazine showing various biological effects in the CNS, as well as endocrine effects, has been isolated from several mammalian tissues. In some cases, it has been identified as a degradation product of thyrotropin-releasing hormone (TRH). In the presence of zinc ions, cyclo(His-Pro) showed hypoglycemic effects and induced body weight reduction in rats.

Boc-D-Leu-OMe is a tyrosine ester derivative that is an aminopeptidase inhibitor. It prevents the breakdown of proteins by inhibiting the enzyme aminopeptidase, which is responsible for the degradation of amino acids at the end of protein synthesis. Boc-D-Leu-OMe has been shown to inhibit both chymotrypsin and trypsin, two enzymes that are involved in protein digestion. This drug can be synthesized from butanoic acid and methyl ester derivatives such as D-leucine methyl ester. The optical rotation of Boc-D-Leu-OMe varies depending on whether it is diastereomeric or not. The diastereomers have a phenolic group with one hydrogen atom bonded to an aromatic ring, whereas those without this group are called enantiomers.

Bachem ID: 4012616.