Angiogenesis
Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.
Subcategories of "Angiogenesis"
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Products of "Angiogenesis"
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Cabozantinib
CAS:Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).Formula:C28H24FN3O5Purity:99.59% - 99.88%Color and Shape:SolidMolecular weight:501.51Pulsatilla Saponin D (90%)
CAS:Controlled ProductApplications Pulsatilla Saponin D shows antiangiogenic and antitumor activity. References Sang-Won, H. et al.: Carcinogen., 34, 2156 (2013);Formula:C47H76O17Purity:90%Color and Shape:NeatMolecular weight:913.1Methyl 6-[[[(2-Chloroethyl)amino]carbonyl]amino]-6-deoxy-Alpha-D-glucopyranoside
CAS:Controlled ProductFormula:C10H19ClN2O6Color and Shape:NeatMolecular weight:298.72VEGFR-2-IN-65
CAS:VEGFR-2-IN-65 (Compound 07) functions as a VEGFR-2 inhibitor. It forms hydrogen bonds with Cys180 and can inhibit tube formation in HUVECs.Formula:C21H18N2O3Color and Shape:SolidMolecular weight:346.379Alpha-Eudesmol
CAS:Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity. References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);Formula:C15H26OColor and Shape:White To Off-WhiteMolecular weight:222.37HIF-2α-IN-1
CAS:HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Formula:C16H8F5NO4SPurity:97.99%Color and Shape:SolidMolecular weight:405.3HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurity:98.92%Color and Shape:SolidMolecular weight:463.29FAK-IN-24
CAS:FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formula:C39H45Cl2F3N8O3Color and Shape:SolidMolecular weight:801.728AZD 9291 (Osimertinib)
CAS:Controlled ProductFormula:C28H33N7O2Color and Shape:Light YellowMolecular weight:499.61KIT/PDGFRA-IN-1
KIT/PDGFRA-IN-1 (compound 19) is an inhibitor targeting the stem cell growth factor receptor (KIT) and platelet-derived growth factor receptor alpha (PDGFRA). Its IC50 values are 2.3 µM for KIT-wt, 12 µM for KIT-D816H, 492 µM for KIT-T670I, 0.8 µM for PDGFRA-wt, 99.9 µM for PDGFRA-D842V, 42.3 µM for PDGFRA-T674I, and 4.3 µM for PDGFRA-G680R. The GR50 values for GIST-T1, T1-a-D842V, and GIST-48B cell lines (gastrointestinal stromal tumor cell lines with PDGFR and KIT mutations) are 12 nM, 8900 nM, and ≥10,000 nM, respectively.Formula:C26H18F3N5O2Color and Shape:SolidMolecular weight:489.449ABP-102
ABP-102 (CT P72) is a bispecific t-cell adduct (BiTE) that acts as a CD3 modulator and selective HER2 modulator for targeting HER2 overexpressing tumors.Color and Shape:Odour LiquidMethylhydroquinone
CAS:Controlled ProductApplications Methylhydroquinone is a marine fungus metabolite, showing activity as an angiosupressor that interferes with the Akt pathway. Allows for screening of novel inhibitors of angiogenesis. References Garcia-Caballero, M. et al.: Biochem. Pharm., 85, 1727 (2013);Formula:C7H8O2Color and Shape:NeatMolecular weight:124.14Taspine
CAS:Controlled ProductApplications It is an alkaloid isolated from Radix et Rhizoma Leonticis. It shows various pharmaceutical properties: bacteriostatic, wound healing, cytotoxicity, immunosuppression, acetilcholinesterase inhibition, and inhibition of the activity of tumor angiogenesis. References Perdue, G.P., et al.: J. Pharm. Sci., 68, 124 (1979), Tsacheva, I., et al.: J. Biosci., 59, 528 (2004), Zhang, Y., et al.: Cancer Lett., 262 103 (2008),Formula:C20H19NO6Color and Shape:NeatMolecular weight:369.37DA-0157
CAS:DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.Formula:C31H43BrN7O2PColor and Shape:SolidMolecular weight:656.597N-(4-((1R,3R)-3-((tert-Butyldimethylsilyl)oxy)-1-cyanocyclopentyl)phenyl)-2-chloronicotinamide
CAS:Controlled ProductApplications N-(4-((1R,3R)-3-((tert-Butyldimethylsilyl)oxy)-1-cyanocyclopentyl)phenyl)-2-chloronicotinamide is an impurity in the synthesis of metabolites of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).Formula:C24H30ClN3O2SiColor and Shape:NeatMolecular weight:456.052IBI-334
IBI-334 is a bispecific antibody targeting both B7-H3 and EGFR. It features an EGFR arm responsible for signal blocking, connected to a modified B7-H3 arm that ensures optimal affinity and binding. The antibody is afucosylated to enhance its antibody-dependent cellular cytotoxicity (ADCC) effects. IBI-334 is widely applicable in EGFR-driven solid tumors.Color and Shape:Odour LiquidDes-(4-(dimethylamino)-2-butenoyl)-Neratinib
CAS:Controlled ProductApplications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy. References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)Formula:C24H20ClN5O2Color and Shape:NeatMolecular weight:445.9Glycerol 1-Monobutyrate (Technical Grade)
CAS:Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process. References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)Formula:C7H14O4Color and Shape:NeatMolecular weight:162.18Methyl 2,5-Dihydroxybenzoate
CAS:Controlled ProductApplications Methyl 2,5-Dihydroxybenzoate is a general reagent used in the synthesis of angiogenesis inhibitors that display anti-tumor activity. References Marin-Ramos, N. et al.: J. Med. Chem, 58, 3757 (2015);Formula:C8H8O4Color and Shape:NeatMolecular weight:168.152-Acetylnaphthalene
CAS:Controlled ProductApplications 2-Acetylnaphthalene is an intermediate used to prepare piperidinyl pyrazoles as potent DNA gyrase inhibitors It is also used in the synthesis of aromatic enone and dienone analogues of curcumin as angiogenesis inhibitors. References Tanitame, A., et al.: J. Med. Chem., 47, 3693 (2004); Robinson, T., et al.: Bioog. Med. Chem. Lett., 13, 115 (2003)Formula:C12H10OColor and Shape:NeatMolecular weight:170.21
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