Angiogenesis
Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.
Subcategories of "Angiogenesis"
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Products of "Angiogenesis"
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MGCD-265 analog
CAS:Glesatinib, an oral tyrosine kinase inhibitor, targets c-Met and VEGFR2 with IC50s of 29 nM and 10 nM, may treat cancer.Formula:C26H20FN5O2S2Purity:98.06% - 98.68%Color and Shape:SolidMolecular weight:517.6EGFR/COX-2-IN-1
EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor that effectively targets EGFRWT, EGFRT790M, COX-1, and COX-2 with IC50 values of 0.12, 0.076, 20.1, and 1.52 μM, respectively. It inhibits MCF-7, HT-29, and A-549 cells with IC50 values of 1.20, 5.14, and 14.81 μM, respectively. The compound induces apoptosis by upregulating Bax protein and downregulating Bcl-2 protein levels. Additionally, EGFR/COX-2-IN-1 significantly increases the proportion of cells in the G2/M phase in MCF-7 cells, demonstrating a broad-spectrum antitumor effect.Formula:C20H17FN6O2S2Color and Shape:SolidMolecular weight:456.521-(Phenylmethyl)-4-piperidinamine
CAS:Controlled ProductApplications 1-(Phenylmethyl)-4-piperidinamine is used in the preparation of 4-substituted coumarins as novel acetylcholinesterase inhibitors used in the treatment and various therapeutic approaches to Alzheimer’s disease. It is also used in the synthesis of nicotinamide derivatives as anti-angiogenic agents. References Razavi, S. et al.: Eur. J. Med. Chem., 64, 252 (2013); Choi, H. et al.: Bioorg. Med. Chem. Lett., 23, 2083 (2013);Formula:C12H18N2Color and Shape:NeatMolecular weight:190.28AZ 5104 Hydrochloride
CAS:Stability Hygroscopic Applications The hydrochloride salt of AZ 5104 (A795170), which is a derivative of AZD 9291 (A808075) and a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC). References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);Formula:C27H31N7O2·HClColor and Shape:NeatMolecular weight:522.04HER2-IN-21
CAS:HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.Formula:C20H18N4O3SColor and Shape:SolidMolecular weight:394.447M1002
CAS:M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.Formula:C15H8F6N2O2SPurity:99.73%Color and Shape:SolidMolecular weight:394.29Ref: TM-T61822
1mg52.00€5mg97.00€10mg153.00€25mg249.00€50mg369.00€100mg545.00€500mg1,130.00€1mL*10mM (DMSO)114.00€Silymarin
CAS:Silymarin, a liver-aiding polyphenolic flavonoid, is extracted from milk thistle seeds.Formula:C25H22O10Purity:98%Color and Shape:Yellow And Brown PowderMolecular weight:482.44ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Formula:C20H21N5O2Purity:99.94%Color and Shape:SolidMolecular weight:363.41Ref: TM-T13398
1mg48.00€5mg97.00€10mg160.00€25mg255.00€50mg353.00€100mg452.00€200mg630.00€1mL*10mM (DMSO)105.00€AFP464 free base
CAS:AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.Formula:C22H23F3N4O3Purity:98%Color and Shape:SolidMolecular weight:448.444-Fmoc-3(R)-morpholinecarboxylic Acid
CAS:Controlled ProductApplications 4-Fmoc-3(R)-morpholinecarboxylic Acid is used to prepare 125I-labeled morpholine-containing RGD ligand of αvβ3 integrin as angiogenesis imaging probe. References Bianchini, F., et al.: J. Med. Chem., 55, 5024 (2012)Formula:C20H19NO5Color and Shape:NeatMolecular weight:353.37YH32367
YH32367 (ABL105) is a bispecific antibody targeting HER2 and 4-1BB. It induces the secretion of IFN-γ, resulting in the death of tumor cells when co-cultured with hPBMC and HER2-expressing tumor cells. YH32367 demonstrates notable antitumor activity.Color and Shape:Odour LiquidN-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine
CAS:Controlled ProductFormula:C20H16FN5O3Color and Shape:Light Yellow To YellowMolecular weight:393.37FGFR2/3-IN-2
CAS:FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.Formula:C29H23FN6O3Color and Shape:SolidMolecular weight:522.53Prednisolone 21-Hemisuccinate Sodium Salt
CAS:Applications Prednisolone 21-hemisuccinate sodium salt is a steroid for proteomics research. It can be used in biological study of inhibition of perioperative Solu-Decortin administration on angiogenic host tissue response to porous Medpor implanted in dorsal skinfold chamber in mouse. References Ehrmantraut, S., et al.: Eur Cells Mater, 19, 107 (2010)Formula:C25H31NaO8Color and Shape:NeatMolecular weight:482.5Cloperastine fendizoate
CAS:Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formula:C40H38ClNO5Purity:99.85%Color and Shape:SolidMolecular weight:648.19(Rac)-Arnebin 1
CAS:(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.Formula:C21H22O6Purity:99.09% - 99.81%Color and Shape:SolidMolecular weight:370.4Osimertinib N'-Oxide
CAS:Controlled ProductApplications Osimertinib N'-Oxide is used in the preparation of EGFR inhibitors, which are used in targeted treatment of cancer References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720Formula:C28H33N7O3Color and Shape:NeatMolecular weight:515.61EGFR-IN-2
CAS:EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.Formula:C26H33N9O3SPurity:100%Color and Shape:SolidMolecular weight:551.66HIF-IN-1
CAS:HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Formula:C17H12N2OPurity:99.48%Color and Shape:SolidMolecular weight:260.29
