Angiogenesis
Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.
Subcategories of "Angiogenesis"
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Products of "Angiogenesis"
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Ibuprofen Lysine
CAS:Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.Formula:C19H32N2O4Purity:99.66%Color and Shape:CoaMolecular weight:352.47(-)-Limonene
CAS:Controlled ProductApplications (-)-Limonene is present in blood oranges which show inhibition of angiogenesis in human colon cancer cells. Extracted from the oils of Mentha spicata it shows antimicrobial activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chidambara Murthy, K. et al.: Life Sci.,91, 429 (2012); Aggarwal, K. et al.: Flav. Frag. J., 17, 59 (2002);Formula:C10H16Color and Shape:NeatMolecular weight:136.23Naluzotan
CAS:Naluzotan(PRX 00023) is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+Formula:C23H38N4O3SPurity:100%Color and Shape:SolidMolecular weight:450.64GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Formula:C18H15N3O2Purity:98.20%Color and Shape:SolidMolecular weight:305.33Ref: TM-T15396
1mg70.00€5mg135.00€10mg188.00€25mg325.00€50mg465.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)149.00€Deguelin
CAS:Controlled ProductApplications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers. References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);Formula:C23H22O6Color and Shape:Light YellowMolecular weight:394.422,4-DPD
CAS:2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Formula:C11H13NO4Purity:99.74%Color and Shape:Yellow Solid CrystallineMolecular weight:223.23E-4031
CAS:E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formula:C21H29Cl2N3O3SPurity:99.31% - 99.87%Color and Shape:SolidMolecular weight:474.44Protein kinase inhibitor 13
CAS:Protein kinase inhibitor 13 (Compound I-90) functions as a kinase inhibitor, specifically targeting kinases such as PIM-1, CDK-2, GSK-3, and SRC.Formula:C19H20FN5OSColor and Shape:SolidMolecular weight:385.458PM-8002
PM-8002 is a bispecific antibody that targets PD-L1 and VEGF-A. It is applicable for research on solid tumors.Color and Shape:Odour LiquidScr-IN-1
Scr-IN-1 (Compound 4e) is a tyrosine kinase inhibitor demonstrating inhibitory activity against HCT-116 and MIA-PaCa-2 cells, with IC50 values of 0.16 μM and 1.16 μM, respectively. It shows selectivity towards HCT-116 cells and MIA-PaCa-2 cells, with a selectivity index (SI) greater than 625 and 86. Scr-IN-1 induces apoptosis in HCT-116 colon cancer cells without altering the proportion of necrotic cells and is a potential novel SRC kinase inhibitor for HCT-116 cells. This compound is suitable for cancer research.Formula:C26H16ClF3N2O3Color and Shape:SolidMolecular weight:496.87MY-1576
MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.Formula:C25H29ClN8O2Color and Shape:SolidMolecular weight:509Desidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.Formula:C16H16N2O6Purity:98%Color and Shape:SolidMolecular weight:332.31Ref: TM-T5176
1mg35.00€2mg52.00€5mg94.00€10mg167.00€25mg300.00€50mg516.00€100mg732.00€1ml*10 (DMSO)112.00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Formula:C17H12F3NO4SPurity:99.34% - 99.41%Color and Shape:SolidMolecular weight:383.34Ref: TM-T16679
1mg70.00€5mg153.00€10mg216.00€25mg411.00€50mg660.00€100mg938.00€200mg1,264.00€1mL*10mM (DMSO)166.00€rac cis-3-((tert-Butyldimethylsilyl)oxy)-1-(4-nitrophenyl)cyclopentanecarbonitrile
CAS:Controlled ProductFormula:C18H26N2O3SiColor and Shape:NeatMolecular weight:346.496HIF-1 inhibitor-4
CAS:HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Formula:C18H19IN2O2Purity:99.17%Color and Shape:SolidMolecular weight:422.26Ref: TM-T67767
1mg48.00€5mg96.00€10mg157.00€25mg281.00€50mg454.00€100mg702.00€200mg938.00€1mL*10mM (DMSO)116.00€LNK01004
CAS:LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.Formula:C26H31N7O2Color and Shape:SolidMolecular weight:473.57Narciclasine
CAS:Controlled ProductApplications Narciclasine is an antiproliferative and pro-apoptotic inducer.Formula:C14H13NO7Color and Shape:Light Yellow To BeigeMolecular weight:307.2555Tyrphostin AG 112
CAS:Controlled ProductApplications Tyrphostin AG 112 is an EGFR inhibitor.Formula:C13H8N4OColor and Shape:NeatMolecular weight:236.236-Methylheptanoic Acid (>90%)
CAS:Controlled ProductApplications 6-Methylheptanoic acid is used as a reagent to synthesize analogues of Eponemycin, an antibiotic that also exhibits anti-angiogenic activity by inhibiting proteasome function. 6-Methylheptanoic acid naturally occurs as a component of the scent chemical of the brushtail possum. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References McLean, S., et al.: J. Chem. Ecol., 38, 1318 (2012); Oikawa, T., et al.: Biochem. Biophys. Res. Comm., 181, 1070 (1991); Sin, N., et al.: Bioorg. Med. Chem., 6, 1209 (1998)Formula:C8H16O2Purity:>90%Color and Shape:NeatMolecular weight:144.212-Bromoethylcyclopropane
CAS:Controlled ProductApplications 2-Bromoethylcyclopropane is used as a reagent to synthesize 22-Hydroxycholesterol (H918010) derivatives, compounds that act as serum cholesterol lowering agents. 2-Bromoethylcyclopropane is also used to prepare pyridazinones, compounds that act as cyclooxygenase 2-inhibitors (they possess anti-inflammatory and antiangiogenic effects). References Chorvat, R., et al.: J. Med. Chem., 28, 194 (1985); Masferrer, J., et al.: Ann. New York Acad. Sci., 889, 84 (1999); Willoughby, D., et al.: Lancet, 355, 646 (2000)Formula:C5H9BrColor and Shape:NeatMolecular weight:149.03
