EGFR
EGFR (epidermal growth factor receptor) inhibitors are compounds that block the signaling of EGFR, a receptor that is often overexpressed in various cancers and plays a critical role in angiogenesis. EGFR inhibitors are used to prevent tumor growth and metastasis by disrupting the pathways that promote blood vessel formation in tumors. These inhibitors are widely used in cancer research and therapy. At CymitQuimica, we offer a diverse selection of high-quality EGFR inhibitors to support your research in oncology and angiogenesis.
Products of "EGFR"
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Naquotinib mesylate
CAS:Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFormula:C31H46N8O6SPurity:98%Color and Shape:SolidMolecular weight:658.81SYR127063
CAS:SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.Formula:C23H20ClF3N4O3Purity:98.57%Color and Shape:SolidMolecular weight:492.88Icotinib
CAS:Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formula:C22H21N3O4Purity:100%Color and Shape:SolidMolecular weight:391.42Ref: TM-T6153
1mg48.00€2mg64.00€5mg96.00€10mg155.00€25mg283.00€50mg527.00€100mg712.00€1mL*10mM (DMSO)97.00€KI8751
CAS:KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.Formula:C24H18F3N3O4Purity:99.22% - 99.9%Color and Shape:SolidMolecular weight:469.41Ref: TM-T2446
2mg37.00€5mg52.00€10mg86.00€25mg156.00€50mg294.00€100mg472.00€200mg670.00€1mL*10mM (DMSO)56.00€PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Formula:C18H18Cl2N6OPurity:96.78%Color and Shape:SolidMolecular weight:405.28Mutant EGFR inhibitor
CAS:Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.Formula:C27H30ClN7O2Purity:96.21% - 98%Color and Shape:SolidMolecular weight:520.03Ref: TM-T2705
1mg37.00€2mg52.00€5mg80.00€10mg97.00€25mg168.00€50mg264.00€100mg379.00€500mgTo inquire1mL*10mM (DMSO)104.00€Cloperastine fendizoate
CAS:Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formula:C40H38ClNO5Purity:99.85%Color and Shape:SolidMolecular weight:648.19Avitinib
CAS:Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Formula:C26H26FN7O2Purity:100%Color and Shape:SolidMolecular weight:487.53Tyrosine kinase-IN-7
CAS:Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity.Formula:C16H15N3OSPurity:99.93%Color and Shape:SolidMolecular weight:297.38EGFR-IN-130
EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.Formula:C27H25N3O6SColor and Shape:SolidMolecular weight:519.57Trastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Purity:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Color and Shape:LiquidMolecular weight:Approximately 145.53 kDaEGFR-IN-138
EGFR-IN-138 (compound 19) is a potent inhibitor of EGFR, with IC50 values of 37, 2.6, and 1.9 nM for the wild-type, L858R, and T790M EGFR, respectively.Formula:C42H37N7O5Color and Shape:SolidMolecular weight:719.79Modotuximab
CAS:Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the internalization and degradation of EGFR.Purity:95% - 95%Color and Shape:LiquidAZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purity:97.07%Color and Shape:SolidMolecular weight:522.04N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine
CAS:Formula:C29H26ClFN4O4SPurity:98%Color and Shape:SolidMolecular weight:581.0575Tilatamig
Tilatamig is a humanized antibody of the Ig(G1-κ, G1-λ2) type targeting EGFR/MET.Color and Shape:Odour LiquidEGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 60-78 kDa based on Tris-Bis PAGE result.Anti-EGFR Monoclonal Antibody-AF647
Anti-EGFR Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF647 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaNeptinib
CAS:Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.Formula:C22H23ClFN5O2Color and Shape:SolidMolecular weight:443.90EGFR-IN-84
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lungFormula:C25H20N6O3S2Purity:98%Color and Shape:SolidMolecular weight:516.59Serclutamab
CAS:Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).Purity:98%Color and Shape:LiquidAnti-Phospho-EGFR (Tyr1068) Antibody (3Q245)
Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) is an antibody targeting Phospho-EGFR (Tyr1068). Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) can be used in ELISA, WB.Color and Shape:Odour LiquidAZD8931 diFuMaric acid
CAS:AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).Formula:C31H33ClFN5O11Purity:99.92%Color and Shape:SolidMolecular weight:706.1Ref: TM-T8751
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)255.00€Caxmotabart
Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.Color and Shape:Odour LiquidAnti-Phospho-EGFR (Tyr1092) Antibody (9I899)
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.Color and Shape:Odour LiquidMubritinib
CAS:Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Formula:C25H23F3N4O2Purity:98.61% - 99.87%Color and Shape:SolidMolecular weight:468.47Daphnetin
CAS:Formula:C9H6O4Purity:>90.0%(HPLC)Color and Shape:White to Light yellow to Light red powder to crystalMolecular weight:178.14DZD1516
CAS:DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFormula:C28H27F2N7O3Purity:98%Color and Shape:SolidMolecular weight:547.56SKLB 1028
CAS:SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Formula:C24H29N9Purity:99.71% - 99.85%Color and Shape:SolidMolecular weight:443.55Ref: TM-T34656
1mg56.00€5mg119.00€10mg187.00€25mg378.00€50mg560.00€100mg800.00€500mg1,644.00€1mL*10mM (DMSO)143.00€(E/Z)-CP-724714
CAS:(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formula:C27H27N5O3Purity:98%Color and Shape:SolidMolecular weight:469.54Limertinib
CAS:Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formula:C29H32ClN7O2Purity:97.44%Color and Shape:SolidMolecular weight:546.06Ref: TM-T35897
1mg90.00€5mg187.00€10mg316.00€25mg637.00€50mg827.00€100mg1,169.00€200mg1,586.00€1mL*10mM (DMSO)250.00€Tuxobertinib
CAS:Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formula:C29H29ClN6O4Purity:99.22%Color and Shape:SolidMolecular weight:561.03Ref: TM-T9072
2mg40.00€5mg60.00€10mg96.00€25mg188.00€50mg354.00€100mg525.00€200mg752.00€1mL*10mM (DMSO)74.00€EGFR-IN-149
CAS:EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.Formula:C16H15N3OSColor and Shape:SolidMolecular weight:297.375Matuzumab
CAS:Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Purity:95%Color and Shape:LiquidMolecular weight:145.9 kDaNorcantharidin
CAS:Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formula:C8H8O4Purity:99.29%Color and Shape:SolidMolecular weight:168.15Sunvozertinib
CAS:Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formula:C29H35ClFN7O3Purity:98.11% - 99.71%Color and Shape:SolidMolecular weight:584.08Ref: TM-T64124
1mg35.00€5mg64.00€10mg89.00€25mg131.00€50mg212.00€100mg373.00€500mg1,388.00€1mL*10mM (DMSO)159.00€ZM323881 hydrochloride
CAS:ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formula:C22H19ClFN3O2Purity:100%Color and Shape:SolidMolecular weight:411.86Genistein
CAS:Formula:C15H10O5Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:270.24WS6
CAS:WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C29H31F3N6O3Purity:97.23% - 99.83%Color and Shape:SolidMolecular weight:568.59(Rac)-JBJ-04-125-02
CAS:(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Formula:C29H26FN5O3SPurity:95.85%Color and Shape:SolidMolecular weight:543.61Ref: TM-T8872
1mg105.00€5mg216.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€1mL*10mM (DMSO)263.00€TYRPHOSTIN RG 13022
CAS:Formula:C16H14N2O2Purity:98%Color and Shape:SolidMolecular weight:266.29456000000005AV-412
CAS:AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formula:C41H44ClFN6O7S2Purity:99.85% - 99.92%Color and Shape:SolidMolecular weight:851.41Ref: TM-T10419
1mg44.00€2mg58.00€5mg95.00€10mg144.00€25mg254.00€50mg424.00€100mg613.00€1mL*10mM (DMSO)136.00€MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurity:98.53%Color and Shape:SolidMolecular weight:314.38D-69491 hydrochloride
CAS:D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.Formula:C25H26Cl2FN7O3Color and Shape:SolidMolecular weight:562.42Petosemtamab
CAS:Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.97 kDaTyrphostin AG 879
CAS:Formula:C18H24N2OSPurity:>98.0%(HPLC)Color and Shape:Light yellow to Yellow to Orange powder to crystalMolecular weight:316.46AZD3759 hydrochloride
CAS:AZD3759 hydrochloride is an oral, CNS-penetrant EGFR inhibitor with IC50s of 0.2/0.3/0.2 nM.Formula:C22H24Cl2FN5O3Purity:99.62%Color and Shape:SolidMolecular weight:496.36Ref: TM-T4249
2mg35.00€5mg48.00€10mg65.00€25mg99.00€50mg170.00€100mg280.00€200mg406.00€1mL*10mM (DMSO)51.00€Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formula:C13H8N4OPurity:97.01%Color and Shape:SolidMolecular weight:236.23Allitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formula:C24H18ClFN4O2Purity:99.10% - 99.28%Color and Shape:SolidMolecular weight:448.88Ref: TM-T14336
1mg52.00€5mg111.00€10mg175.00€25mg329.00€50mg494.00€100mg700.00€1mL*10mM (DMSO)135.00€Alflutinib mesylate
CAS:Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.Formula:C29H35F3N8O5SPurity:97.94% - 99.81%Color and Shape:SolidMolecular weight:664.7EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFormula:C20H21N7O2SPurity:98%Color and Shape:SolidMolecular weight:423.49Becotatug
CAS:Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugatePurity:98%Color and Shape:LiquidPertuzumab
CAS:Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2Purity:98.00%Color and Shape:LiquidMolecular weight:148 kDaEGFR-IN-83
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50Formula:C22H17F3N4OPurity:98%Color and Shape:SolidMolecular weight:410.39O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formula:C21H22ClFN4O3Purity:97.17%Color and Shape:SolidMolecular weight:432.88Ref: TM-T16369
1mg56.00€5mg111.00€10mg170.00€25mg343.00€50mg547.00€100mg783.00€1mL*10mM (DMSO)120.00€Befotertinib
CAS:Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.Formula:C29H32F3N7O2Purity:99.40%Color and Shape:SolidMolecular weight:567.61Ref: TM-T39275
1mg88.00€5mg187.00€10mg298.00€25mg525.00€50mg747.00€100mg1,026.00€1mL*10mM (DMSO)235.00€EGFR-IN-124
EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.Color and Shape:Odour SolidEAI045
CAS:EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.Formula:C19H14FN3O3SPurity:98.00% - 99.73%Color and Shape:SolidMolecular weight:383.4Multi-target kinase inhibitor 2
Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 valuesPurity:98%Color and Shape:Odour SolidSimotinib
CAS:Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.Formula:C25H26ClFN4O4Purity:99.7%Color and Shape:SolidMolecular weight:500.95AZ-5104
CAS:AZ5104 is a potent EGFR inhibitor.Formula:C27H31N7O2Purity:98.40% - 99.9%Color and Shape:Solid PowderMolecular weight:485.58EGFR-IN-85
CAS:EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFRFormula:C26H30N8O2Purity:98%Color and Shape:SolidMolecular weight:486.57Theliatinib
CAS:Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formula:C25H26N6O2Purity:99.67%Color and Shape:SolidMolecular weight:442.51EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS:EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)Formula:C23H21N3O3Purity:99.55%Color and Shape:SolidMolecular weight:387.43Ref: TM-T21954
1mg75.00€2mg94.00€5mg140.00€10mg205.00€25mg371.00€50mg557.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)157.00€EGFRVIII Protein, Human, Recombinant (His & Avi)
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.YH32367
YH32367 (ABL105) is a bispecific antibody targeting HER2 and 4-1BB. It induces the secretion of IFN-γ, resulting in the death of tumor cells when co-cultured with hPBMC and HER2-expressing tumor cells. YH32367 demonstrates notable antitumor activity.Color and Shape:Odour LiquidDuligotuzumab
CAS:Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody targeting Her3 (ErbB3) [1].Purity:98%Color and Shape:LiquidARRY-380 (analog )
CAS:ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.Formula:C29H27N7O4SPurity:98.22%Color and Shape:SolidMolecular weight:569.63Ref: TM-T2518
1mg35.00€2mg49.00€5mg74.00€10mg110.00€25mg180.00€50mg266.00€100mgTo inquire1mL*10mM (DMSO)96.00€LY 456236 hydrochloride
CAS:LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Formula:C16H16ClN3O2Purity:99.89%Color and Shape:SolidMolecular weight:317.77AG 1478 Hydrochloride
CAS:Formula:C16H14ClN3O2·HClPurity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:352.22EGFR/VEGFR2-IN-2
EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.Formula:C24H15FO3Color and Shape:SolidMolecular weight:370.37EGFR-IN-79
EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy.Formula:C23H16ClN3O3Purity:98%Color and Shape:SolidMolecular weight:417.84lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formula:C14H13NO5Purity:97.77%Color and Shape:Yellow To Tan PowderMolecular weight:275.26Ref: TM-T4185
1mg44.00€2mg58.00€5mg87.00€10mg160.00€25mg349.00€50mg518.00€100mg747.00€1mL*10mM (DMSO)95.00€Amivantamab
CAS:Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.Purity:97.24% (SEC-HPLC) - 99.74%Color and Shape:LiquidMolecular weight:145.88 kDaEGFR-IN-2
CAS:EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.Formula:C26H33N9O3SPurity:100%Color and Shape:SolidMolecular weight:551.66EGFR/CSC-IN-1
CAS:EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potentialFormula:C54H54Cl2FN7O7S2Purity:98%Color and Shape:SolidMolecular weight:1067.08EGFR-IN-135
EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.Formula:C12H14N4OS2Color and Shape:SolidMolecular weight:294.4G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purity:97.30%Color and Shape:SolidMolecular weight:383.39Ref: TM-T8742
1mg50.00€5mg97.00€10mg145.00€25mg259.00€50mg374.00€100mg523.00€200mg710.00€1mL*10mM (DMSO)105.00€Avitinib maleate
CAS:Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Formula:C30H30FN7O6Purity:98% - 99.74%Color and Shape:SolidMolecular weight:603.61EGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.Formula:C17H15N7O5SColor and Shape:SolidMolecular weight:429.41EGFR-IN-136
EGFR-IN-136 (compound 21v) is a potent inhibitor of EGFR, demonstrating IC50 values of 20.2 nM, 1.2 nM, 2.3 nM, and 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, and EGFRLR/TM/CS, respectively. It exhibits antiproliferative and antitumor activities and holds potential for research in non-small cell lung cancer (NSCLC).Formula:C30H36N7O4PMolecular weight:589.625Cetuximab MMAE
Cetuximab-MMAE, an antibody-drug conjugate (ADC), combines an EGFR-targeting antibody with Monomethyl auristatin E (MMAE) to investigate colorectal and head and neck cancers.Color and Shape:LiquidMolecular weight:150 kDaTyrphostin AG528
CAS:Formula:C18H14N2O3Purity:>97.0%(HPLC)Color and Shape:Light yellow to Amber to Dark green powder to crystalMolecular weight:306.32Rociletinib
CAS:Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplasticFormula:C27H28F3N7O3Purity:98.39% - 99.25%Color and Shape:SolidMolecular weight:555.55CNX-2006
CAS:CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.Formula:C26H27F4N7O2Purity:98.85% - 99.16%Color and Shape:SolidMolecular weight:545.53Brivanib
CAS:Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormula:C19H19FN4O3Purity:98.87%Color and Shape:SolidMolecular weight:370.38Ref: TM-T6036
1mg47.00€5mg88.00€10mg144.00€25mg259.00€50mg375.00€100mg560.00€200mg815.00€1mL*10mM (DMSO)97.00€NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formula:C24H26N4O3Purity:99.38%Color and Shape:SolidMolecular weight:418.49Ref: TM-T16343
1mg85.00€5mg160.00€10mg250.00€25mg424.00€50mg562.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)170.00€Tyrphostin A25
CAS:Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formula:C10H6N2O3Purity:98.76%Color and Shape:Yellow Green Powder /Off-White SolidMolecular weight:202.17SHR-A1201
SHR-A1201 is an antibody-drug conjugate (ADC) targeting HER2. This compound is composed of a humanized anti-HER2 antibody, the linker SMCC, and the cytotoxic payload Mertansine, which is a microtubule inhibitor. SHR-A1201 is utilized in research for HER2-positive breast cancer.Formula:C50H63ClF3N5O12Color and Shape:LiquidMolecular weight:1018.51MTX-241F
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families.Formula:C20H14ClFN6Purity:98%Color and Shape:SolidMolecular weight:392.82Tyrphostin 23
CAS:Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.Formula:C10H6N2O2Purity:99.19% - 99.7%Color and Shape:Yellow-Tan SolidMolecular weight:186.17Tarlox-TKI
CAS:Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formula:C19H18BrClN6OPurity:97.03%Color and Shape:SolidMolecular weight:461.74Olmutinib
CAS:Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Formula:C26H26N6O2SPurity:99.63%Color and Shape:SolidMolecular weight:486.59Ref: TM-T6918
2mg39.00€5mg57.00€10mg88.00€25mg137.00€50mg180.00€100mg283.00€200mg462.00€1mL*10mM (DMSO)59.00€Almonertinib hydrochloride
CAS:Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Formula:C30H36ClN7O2Purity:98.01% - 98.12%Color and Shape:SolidMolecular weight:562.12′-Thioadenosine
CAS:2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFormula:C10H13N5O3SPurity:98%Color and Shape:SolidMolecular weight:283.31EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted)BI-4732
CAS:DL-Homocystine is a mutagen secreted by F. nucleatum.Formula:C32H36N10O2Purity:98.88%Color and Shape:SolidMolecular weight:592.69Olmutinib
CAS:Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorFormula:C26H26N6O2SPurity:99.14%Color and Shape:SolidMolecular weight:486.59Ref: TM-T8460
2mg35.00€5mg57.00€10mg93.00€25mg131.00€50mg185.00€100mg283.00€200mg464.00€1mL*10mM (DMSO)63.00€AEE788
CAS:AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formula:C27H32N6Purity:100% - 98.94%Color and Shape:SolidMolecular weight:440.58Ref: TM-T2116
2mg47.00€5mg70.00€10mg103.00€25mg188.00€50mg325.00€100mg490.00€500mg1,103.00€1mL*10mM (DMSO)77.00€
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