EGFR
EGFR (epidermal growth factor receptor) inhibitors are compounds that block the signaling of EGFR, a receptor that is often overexpressed in various cancers and plays a critical role in angiogenesis. EGFR inhibitors are used to prevent tumor growth and metastasis by disrupting the pathways that promote blood vessel formation in tumors. These inhibitors are widely used in cancer research and therapy. At CymitQuimica, we offer a diverse selection of high-quality EGFR inhibitors to support your research in oncology and angiogenesis.
Products of "EGFR"
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EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formula:C25H18N4O3Purity:98%Color and Shape:SolidMolecular weight:422.44TX2-120-1
CAS:TX2-120-1 possesses the ability to bind with Her3, exhibiting an IC50 of 56 nM for Her3. It can be utilized in the synthesis of TX2-121-1.Formula:C26H27N7O2Color and Shape:SolidMolecular weight:469.544-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
CAS:Formula:C16H16ClN3O3Purity:97.0%Molecular weight:333.7695EGFR-IN-73
CAS:EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formula:C19H17ClFN3O4Purity:98%Color and Shape:SolidMolecular weight:405.81WHI-P258
CAS:WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formula:C16H15N3O2Purity:99.64% - 99.95%Color and Shape:SolidMolecular weight:281.31AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.39%Color and Shape:Yellow SolidMolecular weight:294.3EGFR-IN-81
EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69Formula:C28H24F3N5O4Purity:98%Color and Shape:SolidMolecular weight:551.52LCH-7749944
CAS:LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Formula:C20H22N4O2Purity:99.48%Color and Shape:SolidMolecular weight:350.41Ref: TM-T11826
1mg49.00€5mg108.00€10mg164.00€25mg284.00€50mg424.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)116.00€WHI-P180 Hydrochloride
CAS:Formula:C16H15N3O3·HClPurity:>97.0%(T)(HPLC)Color and Shape:White to Light gray to Light yellow powder to crystalMolecular weight:333.77Methyl 2,5-dihydroxycinnamate
CAS:Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.Formula:C10H10O4Purity:98.98%Color and Shape:CrystallineMolecular weight:194.18HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Formula:C29H34ClN7OPurity:100% - 99.75%Color and Shape:SolidMolecular weight:532.08EGFR Protein, Human, Recombinant (His & Avi)
EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.Necitumumab
Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Color and Shape:LiquidMolecular weight:145.5 kDaChrysophanol
CAS:Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.Formula:C15H10O4Purity:97.91% - 99.7%Color and Shape:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMolecular weight:254.24Ligustroside
CAS:Ligustroside mildly inhibits PGE2, has slight antioxidant and anti-inflammatory effects, and is moderately antiviral against parainfluenza 3.Formula:C25H32O12Purity:98%Color and Shape:SolidMolecular weight:524.512-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)-
CAS:Formula:C18H24N2OSPurity:95%Color and Shape:SolidMolecular weight:316.461CUDC-101
CAS:CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Formula:C24H26N4O4Purity:95.76% - 99.17%Color and Shape:SolidMolecular weight:434.49Tucatinib
CAS:Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).Formula:C26H24N8O2Purity:99.05% - 99.96%Color and Shape:SolidMolecular weight:480.52Ref: TM-T2364
1g1,130.00€2mg35.00€5mg49.00€10mg79.00€25mg124.00€50mg187.00€100mg350.00€500mg825.00€1mL*10mM (DMSO)87.00€EGFR-IN-129
EGFR-IN-129 (Compound 10b) is an effective, selective EGFR inhibitor with an IC50 of 51.2 nM and demonstrates broad-spectrum antiproliferative activity against the NCI tumor panel.Formula:C21H18N4O3SColor and Shape:SolidMolecular weight:406.46EGFR/CDK2-IN-3
EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively.Formula:C30H20N6OSPurity:98%Color and Shape:SolidMolecular weight:512.58
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