EGFR
EGFR (epidermal growth factor receptor) inhibitors are compounds that block the signaling of EGFR, a receptor that is often overexpressed in various cancers and plays a critical role in angiogenesis. EGFR inhibitors are used to prevent tumor growth and metastasis by disrupting the pathways that promote blood vessel formation in tumors. These inhibitors are widely used in cancer research and therapy. At CymitQuimica, we offer a diverse selection of high-quality EGFR inhibitors to support your research in oncology and angiogenesis.
Products of "EGFR"
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Osimertinib dimesylate
CAS:Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Formula:C30H41N7O8S2Purity:98%Color and Shape:SolidMolecular weight:691.82PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formula:C26H35Cl2N7OPurity:99.23%Color and Shape:SolidMolecular weight:532.51Ref: TM-T23127
1mg35.00€5mg92.00€10mg149.00€25mg305.00€50mg492.00€100mg700.00€200mg938.00€1mL*10mM (DMSO)125.00€AG 555
CAS:AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.Formula:C19H18N2O3Purity:100% - 99.51%Color and Shape:SolidMolecular weight:322.36Chamigrenal
CAS:β-Chamigrenal: Anti-inflammatory, inhibits NO and PGE2 in macrophages, PAF antagonist (IC50=1.2x10^-4 M), weakly cytotoxic to MCF-7 (IC50=30.50 uM).Formula:C15H22OPurity:99.31%Color and Shape:SolidMolecular weight:218.33EGFR-IN-76
CAS:EGFR-IN-76 is a potent EGFR inhibitor.Formula:C30H30ClFN6O2Purity:97.02% - 97.72%Color and Shape:SolidMolecular weight:561.05U3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Color and Shape:LiquidMolecular weight:144.82 kDa (Predicted)AV-412 free base
CAS:AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formula:C27H28ClFN6OColor and Shape:SolidMolecular weight:507Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formula:C33H48O6Purity:99.04% - 99.71%Color and Shape:White Crystalline SolidMolecular weight:540.73Ref: TM-T15735
1mg202.00€2mg341.00€5mg620.00€10mg882.00€25mg1,320.00€50mg1,776.00€100mg2,403.00€1mL*10mM (DMSO)283.00€PF-6274484
CAS:PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formula:C18H14ClFN4O2Purity:97.71%Color and Shape:SolidMolecular weight:372.78Ref: TM-T22396
2mg40.00€5mg60.00€10mg92.00€25mg187.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)66.00€EGFR-IN-1
CAS:EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.Formula:C28H30N6O4Purity:98%Color and Shape:SolidMolecular weight:514.58Anti-EGFR Monoclonal Antibody-AF555
Anti-EGFR Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF555 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaAlmonertinib
CAS:Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.Formula:C30H35N7O2Purity:99.99%Color and Shape:SolidMolecular weight:525.64Ref: TM-T5462
1mg89.00€5mg197.00€10mg311.00€25mg525.00€50mg757.00€100mg1,035.00€500mg2,110.00€1mL*10mM (DMSO)249.00€EBE-A22
CAS:EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.Formula:C17H16BrN3O2Purity:99.85% - 99.88%Color and Shape:SolidMolecular weight:374.234-Epidoxycycline
CAS:4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.Formula:C22H24N2O8Color and Shape:SolidMolecular weight:444.44EGFR-IN-132
CAS:EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.Formula:C27H31N7O3Color and Shape:SolidMolecular weight:501.58AEE 788
CAS:Formula:C27H32N6Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:440.60Pyrotinib dimaleate
CAS:Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Formula:C40H39ClN6O11Purity:98.07% - 99.52%Color and Shape:SolidMolecular weight:815.22Ref: TM-T12594
1mg155.00€5mg457.00€10mg610.00€25mg947.00€50mg1,301.00€100mg1,758.00€1mL*10mM (DMSO)620.00€(E)-AG 556
CAS:AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.Formula:C20H20N2O3Purity:99.48%Color and Shape:Light Yellow PowderMolecular weight:336.38JAK 3 inhibitor IV
CAS:JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormula:C16H19NOPurity:98%Color and Shape:SolidMolecular weight:241.33PP 3
CAS:PP 3 is a Negative control for the Src kinase inhibitor PP 2Formula:C11H9N5Purity:98.61%Color and Shape:Whit To Off-White SolidMolecular weight:211.22Ref: TM-T23176
5mg51.00€10mg79.00€25mg140.00€50mg202.00€100mg305.00€500mg733.00€1mL*10mM (DMSO)55.00€AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Formula:C16H12N2O3Purity:98.69%Color and Shape:SolidMolecular weight:280.28(±)-Norcantharidin
CAS:(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formula:C8H8O4Purity:99.43% - ≥98%Color and Shape:SolidMolecular weight:168.15Mubritinib
CAS:Formula:C25H23F3N4O2Purity:>98.0%(HPLC)Color and Shape:White to Gray to Brown powder to crystalMolecular weight:468.48A-935142
CAS:A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formula:C18H19F3N2O2Purity:100% - 100%Color and Shape:SolidMolecular weight:352.35Tyrphostin AG 490
CAS:Formula:C17H14N2O3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:294.31EGFR-IN-1 hydrochloride
CAS:EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.Formula:C28H31ClN6O4Purity:99.8%Color and Shape:SolidMolecular weight:551.04Ref: TM-T11157L
1mg65.00€5mg150.00€10mg215.00€25mg338.00€50mg452.00€100mg620.00€200mg838.00€1mL*10mM (DMSO)202.00€Mavelertinib
CAS:Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Formula:C18H22FN9O2Purity:100%Color and Shape:SolidMolecular weight:415.42Lumretuzumab
CAS:Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.Color and Shape:LiquidEGFR-IN-82
CAS:EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/Formula:C32H41BrN9O2PPurity:98%Color and Shape:SolidMolecular weight:694.6Almonertinib mesylate
CAS:Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Formula:C31H39N7O5SPurity:98.85%Color and Shape:SolidMolecular weight:621.75Ref: TM-T9865
1mg55.00€5mg116.00€10mg187.00€25mg319.00€50mg449.00€100mg638.00€200mg840.00€1mL*10mM (DMSO)170.00€EGFR-IN-126
CAS:EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.Formula:C28H28BrFN4O3Color and Shape:SolidMolecular weight:567.45Gefitinib-based PROTAC 3
CAS:Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).Formula:C47H57ClFN7O8SPurity:97.29% - 98.25%Color and Shape:SolidMolecular weight:934.51HKI-357
CAS:HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.Formula:C31H29ClFN5O3Purity:95.11%Color and Shape:SolidMolecular weight:574.05Ref: TM-T11569
1mg79.00€5mg153.00€10mg227.00€25mg462.00€50mg662.00€100mg938.00€1mL*10mM (DMSO)187.00€Vandetanib
CAS:Formula:C22H24BrFN4O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:475.36EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formula:C50H49N11O5SColor and Shape:SolidMolecular weight:916.062-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
CAS:Formula:C18H13BrN4OPurity:98%Color and Shape:SolidMolecular weight:381.226Osimertinib
CAS:Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formula:C28H33N7O2Purity:100% - 99.83%Color and Shape:SolidMolecular weight:499.61Ref: TM-T2490
1g154.00€2mg38.00€5mg52.00€10mg62.00€25mg74.00€50mg88.00€100mg103.00€200mg115.00€500mg127.00€1mL*10mM (DMSO)52.00€Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Color and Shape:LiquidWHI-P154
CAS:Formula:C16H14BrN3O3Purity:>98.0%(HPLC)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:376.21Dacomitinib hydrate
CAS:Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family ofFormula:C24H27ClFN5O3Purity:99.52%Color and Shape:SolidMolecular weight:487.96Ref: TM-T19965
5mg50.00€10mg80.00€25mg105.00€50mg140.00€100mg212.00€200mg311.00€1mL*10mM (DMSO)60.00€4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-
CAS:Formula:C16H14ClN3O2Purity:99%Color and Shape:SolidMolecular weight:315.75426000000004Propanedinitrile,2-[(4-methoxyphenyl)methylene]-
CAS:Formula:C11H8N2OPurity:98%Color and Shape:SolidMolecular weight:184.194EGFR-IN-8
CAS:EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLCFormula:C32H23ClF3N7O4Purity:97.45%Color and Shape:SolidMolecular weight:662.02GW 583340 dihydrochloride
CAS:GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formula:C28H27Cl3FN5O3S2Purity:98.80%Color and Shape:SolidMolecular weight:671.03PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formula:C17H13BrN4OPurity:99.13% - 99.7%Color and Shape:SolidMolecular weight:369.22Ref: TM-T6932
1mg39.00€2mg49.00€5mg66.00€10mg89.00€25mg155.00€50mg222.00€100mg310.00€1mL*10mM (DMSO)56.00€MTX-211
CAS:MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Formula:C20H14Cl2FN5O2SPurity:100% - 97.28%Color and Shape:SolidMolecular weight:478.33Ref: TM-T4296
1mg64.00€5mg187.00€10mg284.00€25mg467.00€50mg645.00€100mg873.00€200mg1,159.00€1mL*10mM (DMSO)190.00€EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:60-90 KDa (reducing condition)Trastuzumab rezetecan
CAS:Trastuzumab rezetecan (SHR-A1811) is an antibody-drug conjugate (ADC) targeting HER2. It is composed of a humanized anti-HER2 antibody, a cleavable linker MC-Gly-Gly-Phe-Gly, and an effective payload of the topoisomerase I inhibitor Rezetecán. Trastuzumab rezetecan is utilized in the research of HER2-positive breast cancer.Color and Shape:LiquidEpertinib hydrochloride
CAS:Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.Formula:C30H28Cl2FN5O3Purity:99.14%Color and Shape:SolidMolecular weight:596.48Ref: TM-T11213
1mg92.00€5mg188.00€10mg311.00€25mg533.00€50mg755.00€100mg1,017.00€500mg2,043.00€1mL*10mM (DMSO)255.00€Benidipine hydrochloride
CAS:Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.Formula:C28H32ClN3O6Purity:99.80%Color and Shape:SolidMolecular weight:542.03
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