EGFR
EGFR (epidermal growth factor receptor) inhibitors are compounds that block the signaling of EGFR, a receptor that is often overexpressed in various cancers and plays a critical role in angiogenesis. EGFR inhibitors are used to prevent tumor growth and metastasis by disrupting the pathways that promote blood vessel formation in tumors. These inhibitors are widely used in cancer research and therapy. At CymitQuimica, we offer a diverse selection of high-quality EGFR inhibitors to support your research in oncology and angiogenesis.
Products of "EGFR"
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AG-1478
CAS:AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.Formula:C16H14ClN3O2Purity:99.03% - 99.71%Color and Shape:SolidMolecular weight:315.75EGFR-IN-147
CAS:EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.Formula:C13H13N5OColor and Shape:SolidMolecular weight:255.275Neratinib
CAS:Formula:C30H29ClN6O3Purity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:557.05Tyrphostin A1
CAS:Formula:C11H8N2OPurity:>98.0%(GC)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:184.20Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurity:98% - 99.41%Color and Shape:Colourless To Light-Yellow CrystalMolecular weight:943.47TX1-85-1
CAS:TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Formula:C32H36N8O3Purity:98.12% - 98.12%Color and Shape:SolidMolecular weight:580.68WHI-P154
CAS:WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formula:C16H14BrN3O3Purity:98% - 99.6%Color and Shape:SolidMolecular weight:376.2Sapitinib
CAS:Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFormula:C23H25ClFN5O3Purity:98.89% - 99.83%Color and Shape:SolidMolecular weight:473.93Alflutinib
CAS:Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.Formula:C28H31F3N8O2Purity:99.61%Color and Shape:SolidMolecular weight:568.59Ref: TM-T22254
1mg213.00€5mg435.00€10mg620.00€25mg938.00€50mg1,320.00€100mg1,786.00€1mL*10mM (DMSO)560.00€EGFR-IN-128
EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.Formula:C27H20N4OColor and Shape:SolidMolecular weight:416.47Nezutatug
CAS:Nezutatug, an anti-HER3 antibody, serves as a research tool in cancer studies [1].Purity:98%Color and Shape:LiquidBPI-15086
CAS:BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.Formula:C29H33ClN8O4Color and Shape:SolidMolecular weight:593.08FRF-06-057
FRF-06-057 is an allosteric ATP EGFR inhibitor targeting both wild-type and mutant EGFR, with IC50 values of 17 nM (LR/TM), 29 nM (LR/TM/CS), 220 nM (LR), and >1000 nM (WT).Formula:C19H13N3O3SColor and Shape:SolidMolecular weight:363.39Tyrphostin AG30
CAS:Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.Formula:C10H7NO4Purity:99.02%Color and Shape:SolidMolecular weight:205.17Labuxtinib
CAS:Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formula:C20H16FN5O2Purity:99.77%Color and Shape:SolidMolecular weight:377.37Ref: TM-T79851
1mg139.00€5mg338.00€10mg540.00€25mg1,074.00€50mg1,549.00€100mg2,080.00€200mg2,802.00€1mL*10mM (DMSO)374.00€Anti-EGFR Monoclonal Antibody-AF488
Anti-EGFR Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF488 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaDacomitinib
CAS:Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.Formula:C24H25ClFN5O2Purity:100% - 99.72%Color and Shape:SolidMolecular weight:469.94Ref: TM-T2483
1mg38.00€2mg49.00€5mg79.00€10mg127.00€25mg173.00€50mg227.00€100mg354.00€200mg444.00€500mg730.00€1mL*10mM (DMSO)79.00€Rezivertinib
CAS:Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formula:C27H30N6O3Purity:99.43% - 99.89%Color and Shape:SolidMolecular weight:486.57Ref: TM-T36644
1mg99.00€5mg226.00€10mg364.00€25mg702.00€50mg947.00€100mg1,264.00€200mg1,700.00€1mL*10mM (DMSO)47.00€JH-XI-10-02
CAS:JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.Formula:C53H69N5O9Purity:98%Color and Shape:SolidMolecular weight:920.161EGFR/BRAFV600E-IN-2
E07 Aptamer, targeting the human epidermal growth factor receptor (hEGFR), competes with epidermal growth factor (EGF) for binding to a unique epitope on EGFR.Formula:C25H18N4O2Purity:98%Color and Shape:SolidMolecular weight:406.44BGB-8035
CAS:BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.Formula:C24H31N5O4Purity:96.74%Color and Shape:SolidMolecular weight:453.53Larotinib
CAS:Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.Formula:C24H26ClFN4O4Purity:98.45%Color and Shape:SolidMolecular weight:488.94BEBT-109
CAS:BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.Formula:C27H32N8O3Purity:99.01%Color and Shape:SolidMolecular weight:516.6EGFR-IN-61
CAS:EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Formula:C33H37ClN8O3Purity:98%Color and Shape:SolidMolecular weight:629.15GW 583340
CAS:GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Formula:C28H25ClFN5O3S2Purity:98.68%Color and Shape:SoildMolecular weight:598.11Ref: TM-T22827L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€Biochanin A
CAS:Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.Formula:C16H12O5Purity:97.1% - 98.97%Color and Shape:SolidMolecular weight:284.26BKI-1369
CAS:BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51Anti-EGFR Monoclonal Antibody-PE
Anti-EGFR Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-PE can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaPD 153035 Hydrochloride
CAS:Formula:C16H14BrN3O2·HClPurity:>97.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:396.67Calotatug ginistinag
CAS:Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate (ADC) aimed at targeting HER2. It is connected by a linker (XMT-1519 conjugate-1) to an effective payload that includes a STING agonist (STING agonist-20), presenting potential in immune activation and anti-tumor activity.Color and Shape:LiquidEGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.Color and Shape:Lyophilized PowderMolecular weight:90-120 KDa (reducing condition)EGFR-IN-90
EGFR-IN-90 (compound 34), an orally active EGFR inhibitor, demonstrates potent activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and effectivelyPurity:98%Color and Shape:Odour SolidEpertinib
CAS:Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formula:C30H27ClFN5O3Purity:98%Color and Shape:SolidMolecular weight:560.02SU5204
CAS:SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFormula:C17H15NO2Purity:99.46%Color and Shape:SolidMolecular weight:265.31PAT-505
CAS:PAT-505 is an autologous epidermal growth factor inhibitor.Formula:C23H18ClF2N3O2SPurity:98.84%Color and Shape:SolidMolecular weight:473.92Tesevatinib
CAS:Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.Formula:C24H25Cl2FN4O2Purity:97.89% - 97.89%Color and Shape:SolidMolecular weight:491.39Ref: TM-TQ0166
1mg107.00€2mg156.00€5mg236.00€10mg457.00€25mg750.00€50mg1,026.00€1mL*10mM (DMSO)255.00€NS-062
CAS:NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.Formula:C28H30Cl2F2N6O4Color and Shape:SolidMolecular weight:623.48ZD-4190
CAS:ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.Formula:C19H16BrFN6O2Purity:99.12%Color and Shape:SolidMolecular weight:459.27Ref: TM-T5475
1mg85.00€5mg183.00€10mg275.00€25mg437.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)185.00€TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formula:C26H25ClF3N5O3Purity:99.17%Color and Shape:SolidMolecular weight:547.96Depatuxizumab MMAF
Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.Color and Shape:LiquidMolecular weight:148.24 kDaCP-724714
CAS:CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2Formula:C27H27N5O3Purity:97.10% - 98.82%Color and Shape:SolidMolecular weight:469.54Ref: TM-T4014
1mg44.00€2mg58.00€5mg95.00€10mg157.00€25mg273.00€50mg454.00€100mg660.00€1mL*10mM (DMSO)89.00€EAI001
CAS:EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formula:C19H15N3O2SPurity:100%Color and Shape:SolidMolecular weight:349.41Lazertinib
CAS:Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Formula:C30H34N8O3Purity:98.7% - 99.53%Color and Shape:SolidMolecular weight:554.64Self-assembling peptide pY1
Self-assembling peptide pY1, which aggregates around cancer cells, specifically targets the EGFR receptor. When co-cultured with Ovalbumin (OVA), pY1 effectively inhibits the endocytosis of OVA.Formula:C104H125N24O29PColor and Shape:SolidMolecular weight:2206.22EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Color and Shape:Lyophilized PowderMolecular weight:69.8 kDa (predicted). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.YS-363
CAS:YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (Formula:C30H30N4O3Purity:98%Color and Shape:SolidMolecular weight:494.58EGFR-IN-88
CAS:EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosisFormula:C22H18Cl2N4O2SPurity:98%Color and Shape:SolidMolecular weight:473.37JGK-068S
CAS:Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].Formula:C22H23BrFN5O2Purity:98%Color and Shape:SolidMolecular weight:488.35Tyrphostin AG 1478
CAS:Formula:C16H14ClN3O2Purity:>98.0%(HPLC)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:315.76
