BTK
BTK (Bruton's tyrosine kinase) inhibitors are compounds that specifically target and inhibit BTK, a crucial enzyme involved in B-cell receptor signaling and the regulation of angiogenesis. BTK plays a significant role in the proliferation and survival of cancer cells, particularly in hematological malignancies. By inhibiting BTK, these compounds can disrupt angiogenesis and tumor growth, making them valuable in cancer therapy. At CymitQuimica, we offer a range of high-quality BTK inhibitors to support your research in oncology, immunology, and angiogenesis.
Products of "BTK"
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Found 70 products on this category.
GDC-0834
CAS:GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse andFormula:C33H36N6O3SColor and Shape:SolidMolecular weight:596.74BTK Protein, Human, Recombinant (His)
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.Purity:90%Color and Shape:Lyophilized PowderMolecular weight:78.3 kDa (predicted)CHMFL-BTK-01
CAS:CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.Formula:C38H41N5O5Purity:98%Color and Shape:SolidMolecular weight:647.76PF-06250112
CAS:PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.Formula:C22H20F2N6O2Purity:98%Color and Shape:SolidMolecular weight:438.43Tirabrutinib hydrochloride
CAS:Tirabrutinib hydrochloride is a potent, highly selective, irreversible oral BTK inhibitor.Cost-effective and quality-assured.Formula:C25H23ClN6O3Purity:99.04% - 99.27%Color and Shape:SolidMolecular weight:490.94JNJ-64264681
CAS:JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).Formula:C27H30N6O3SPurity:98%Color and Shape:SolidMolecular weight:518.63(R)-Zanubrutinib
CAS:(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK).Formula:C27H29N5O3Purity:98.04%Color and Shape:SolidMolecular weight:471.55Ref: TM-T13447
1mg39.00€5mg85.00€10mg140.00€25mg226.00€50mg340.00€100mg467.00€200mg648.00€1mL*10mM (DMSO)89.00€G-744
CAS:G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM).Formula:C29H29N5O3SPurity:98%Color and Shape:SolidMolecular weight:527.64Spebrutinib besylate
CAS:Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).Formula:C28H28FN5O6SPurity:98%Color and Shape:SolidMolecular weight:581.62Ibrutinib
CAS:Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.Formula:C25H24N6O2Purity:98% - 99.79%Color and Shape:SolidMolecular weight:440.5BTK inhibitor 1
CAS:BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.Formula:C24H23FN8O2Purity:99.06% - 99.79%Color and Shape:SolidMolecular weight:474.49WS-11
CAS:WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.Formula:C26H22FN9O2Color and Shape:SolidMolecular weight:511.51TL-895
CAS:TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).Formula:C25H26FN5O2Purity:99.59%Color and Shape:SolidMolecular weight:447.5Ref: TM-T9705
2mg42.00€5mg64.00€10mg93.00€25mg180.00€50mg281.00€100mg414.00€200mg587.00€1mL*10mM (DMSO)64.00€Branebrutinib
CAS:Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.Formula:C20H23FN4O2Purity:95.86% - 99.39%Color and Shape:SolidMolecular weight:370.42Ref: TM-T5407
1mg52.00€5mg114.00€10mg177.00€25mg354.00€50mg553.00€100mg793.00€200mg1,093.00€1mL*10mM (DMSO)125.00€Tyrosinase-IN-16
CAS:Tyrosinase-IN-16 inhibited tyrosinase.Formula:C8H6BrN3SPurity:100%Color and Shape:SolidMolecular weight:256.12BTK-IN-38
CAS:BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.Formula:C27H26F2N4O2Color and Shape:SolidMolecular weight:476.52Orelabrutinib
CAS:Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).Formula:C26H25N3O3Purity:97.77% - 99.44%Color and Shape:SolidMolecular weight:427.49Ref: TM-T12317
1mg90.00€5mg187.00€10mg315.00€25mg520.00€50mg720.00€100mg947.00€500mg1,890.00€1mL*10mM (DMSO)216.00€Spebrutinib
CAS:Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplasticFormula:C22H22FN5O3Purity:100% - 97.02%Color and Shape:SolidMolecular weight:423.44Pirtobrutinib
CAS:Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.Formula:C22H21F4N5O3Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:479.43Ref: TM-T36287
1mg37.00€5mg79.00€10mg126.00€25mg283.00€50mg434.00€100mg638.00€500mg1,359.00€1mL*10mM (DMSO)84.00€RN486
CAS:RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).Formula:C35H35FN6O3Purity:99.38%Color and Shape:SolidMolecular weight:606.69JDB175
CAS:JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier.Formula:C26H21F3N4O2Purity:98%Color and Shape:SolidMolecular weight:478.47Cinsebrutinib
CAS:Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment.Formula:C22H26FN3O2Purity:98%Color and Shape:SolidMolecular weight:383.46PROTAC BTK Degrader-6
CAS:PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expressionFormula:C45H47N11O6Purity:98%Color and Shape:SolidMolecular weight:837.92LFM-A13
CAS:LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR,Formula:C11H8Br2N2O2Purity:99.9%Color and Shape:SolidMolecular weight:360BTK-IN-27
CAS:BTK-IN-27 (example 8), a potent BTK inhibitor with an IC50 of 0.2 nM, demonstrates anti-proliferative effects in TMD8 cells with an IC50 of less than 5 nM.Formula:C31H35N7O2Purity:98%Color and Shape:SolidMolecular weight:537.66BTK-IN-16
CAS:BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.Formula:C15H14N4O2Purity:99.04%Color and Shape:SoildMolecular weight:282.3AS-1763
CAS:AS-1763 is an orally available and selective BTK inhibitor with an IC50 of 0.85 nM.Formula:C33H31FN6O3Purity:98%Color and Shape:SolidMolecular weight:578.64ONO-4059 analog
CAS:ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.Formula:C25H24N6O3Purity:99.25%Color and Shape:SolidMolecular weight:456.5Ref: TM-T6921
1mg46.00€2mg59.00€5mg87.00€10mg144.00€25mg279.00€50mg462.00€100mg662.00€1mL*10mM (DMSO)96.00€BIIB129
CAS:BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.Formula:C19H22N6O2Purity:98.56%Color and Shape:SolidMolecular weight:366.42Acalabrutinib enantiomer
CAS:R-Acalabrutinib, a BTK inhibitor,enantiomer, is researched for cancer, autoimmune diseases, and inflammation.Formula:C26H23N7O2Purity:96.68%Color and Shape:SolidMolecular weight:465.51Ref: TM-T67881
1mg77.00€5mg158.00€10mg225.00€25mg338.00€50mg475.00€100mg638.00€200mg845.00€1mL*10mM (DMSO)170.00€(±)-Zanubrutinib
CAS:(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability,Formula:C27H29N5O3Purity:98.19%Color and Shape:SolidMolecular weight:471.55Ref: TM-TQ0039
1mg49.00€5mg97.00€10mg154.00€25mg270.00€50mg432.00€100mg620.00€500mg1,283.00€1mL*10mM (DMSO)106.00€SB-633825
CAS:SB-633825 can inhibit cancer cell growth and angiogenesis.Formula:C28H25N3O3SPurity:98%Color and Shape:SolidMolecular weight:483.58zanubrutinib
CAS:Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).Formula:C27H29N5O3Purity:99.24% - 99.74%Color and Shape:SolidMolecular weight:471.55Ref: TM-T7584
1mg63.00€5mg144.00€10mg250.00€25mg518.00€50mg777.00€100mg1,074.00€1mL*10mM (DMSO)150.00€CHMFL-BMX-078
CAS:CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.Formula:C33H35N7O6Purity:100%Color and Shape:SolidMolecular weight:625.67Tirabrutinib
CAS:Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.Formula:C25H22N6O3Purity:99.75%Color and Shape:SolidMolecular weight:454.48N-piperidine Ibrutinib
CAS:N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.Formula:C22H22N6OPurity:96.65%Color and Shape:SolidMolecular weight:386.45BTK inhibitor 17
CAS:BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.Formula:C25H24N6O3Purity:99.29% - 99.57%Color and Shape:SolidMolecular weight:456.5Ref: TM-T9706
1mg94.00€5mg170.00€10mg264.00€25mg424.00€50mg562.00€100mg787.00€200mg1,035.00€1mL*10mM (DMSO)170.00€NX-2127
CAS:NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferativeFormula:C39H45N9O5Purity:98.11%Color and Shape:SolidMolecular weight:719.83Avitinib
CAS:Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Formula:C26H26FN7O2Purity:100%Color and Shape:SolidMolecular weight:487.53PCI 29732
CAS:PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.Formula:C22H21N5OPurity:99.81%Color and Shape:SolidMolecular weight:371.43Ref: TM-T4337
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg240.00€50mg426.00€100mg627.00€1mL*10mM (DMSO)87.00€BIIB068
CAS:BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.Formula:C23H29N7O2Purity:97.98%Color and Shape:SolidMolecular weight:435.52Ref: TM-T9192
1mg48.00€5mg96.00€10mg160.00€25mg279.00€50mg419.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)105.00€TAK-020
CAS:TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.Formula:C18H17N5O3Purity:98.79%Color and Shape:SolidMolecular weight:351.36Ref: TM-T9529
1mg145.00€5mg354.00€10mg630.00€25mg1,301.00€50mg2,015.00€100mg3,117.00€1mL*10mM (DMSO)378.00€Tilfrinib
CAS:Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.Formula:C17H13N3OPurity:99.73%Color and Shape:SolidMolecular weight:275.3Ref: TM-T17098
1mg46.00€2mg59.00€5mg87.00€10mg137.00€25mg255.00€50mg464.00€100mg680.00€500mg1,406.00€1mL*10mM (DMSO)87.00€DBt-10
DBt-10 is a potent Bruton's tyrosine kinase (BTK) degrader [1].Formula:C68H86ClFN16O6Purity:98%Color and Shape:SolidMolecular weight:1277.96Ibrutinib deacryloylpiperidine
CAS:Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.Formula:C17H13N5OPurity:99.47%Color and Shape:SolidMolecular weight:303.32PCI-33380
CAS:PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.Formula:C46H52BF2N11O3Purity:98%Color and Shape:SolidMolecular weight:855.8Acalabrutinib
CAS:Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.Formula:C26H23N7O2Purity:99.02% - 99.64%Color and Shape:SolidMolecular weight:465.51Ref: TM-T3626
5mg47.00€10mg60.00€25mg82.00€50mg96.00€100mg153.00€200mg227.00€500mg375.00€1mL*10mM (DMSO)50.00€BTK-IN-24
CAS:BTK-IN-24 is a Bruton's tyrosine kinase (BTK) inhibitor with potential anticancer activity, and it can be used in the study of myeloproliferative disorders.Formula:C26H19F4N5O2Purity:99.61%Color and Shape:SolidMolecular weight:509.46Fenebrutinib
CAS:Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).Formula:C37H44N8O4Purity:98.26%Color and Shape:SolidMolecular weight:664.8MT-802
CAS:MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).Formula:C41H41N9O8Purity:95.93% - 97.00%Color and Shape:SolidMolecular weight:787.82Ref: TM-T16157
1mg96.00€5mg187.00€10mg284.00€25mg538.00€50mg730.00€100mg938.00€200mg1,320.00€1mL*10mM (DMSO)245.00€ACP-5862
CAS:ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.Formula:C26H23N7O3Color and Shape:SolidMolecular weight:481.51ARQ 531
CAS:ARQ-531: potent oral BTK inhibitor, anti-cancer potential, IC50 of 0.85/0.39 nM for WT/C481S-BTK.Formula:C25H23ClN4O4Purity:99.59% - 99.63%Color and Shape:SolidMolecular weight:478.93PROTAC BTK Degrader-5
PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton's tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity byFormula:C52H57ClFN9O6Purity:98%Color and Shape:SolidMolecular weight:958.52(Rac)-IBT6A
CAS:(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.Formula:C22H22N6OPurity:98.68%Color and Shape:SolidMolecular weight:386.45Ref: TM-T10626
1mg48.00€5mg93.00€10mg135.00€25mg235.00€50mg344.00€100mg487.00€200mg692.00€1mL*10mM (DMSO)97.00€Btk inhibitor 2
CAS:Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.Formula:C24H25N5O3Purity:99.94%Color and Shape:SolidMolecular weight:431.49Ref: TM-T10629
1mg37.00€2mg52.00€5mg79.00€10mg103.00€25mg227.00€50mg376.00€100mg457.00€1mL*10mM (DMSO)87.00€IBT6A
CAS:IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.Formula:C22H22N6OPurity:99.8% - 99.88%Color and Shape:SolidMolecular weight:386.45BTK-IN-25
CAS:BTK-IN-25 (compound 71) is a potent BTK inhibitor, demonstrating an IC50 of 0.77 nM against BTK(C481S) and achieving an IC50 of 1 nM in DOHH2 cells [1].Formula:C28H27F2N3O5Purity:98%Color and Shape:SolidMolecular weight:523.53Anti-BTK Antibody (3G585)
Anti-BTK Antibody (3G585) is an antibody targeting BTK. Anti-BTK Antibody (3G585) can be used in ELISA, IHC.Color and Shape:Odour LiquidBMX-IN-1
CAS:BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosineFormula:C29H24N4O4SPurity:≥98%Color and Shape:SolidMolecular weight:524.59(S)-Sunvozertinib
CAS:(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formula:C29H35ClFN7O3Purity:99.64%Color and Shape:SolidMolecular weight:584.08Edralbrutinib
CAS:Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood andFormula:C26H21F2N5O3Purity:99.47%Color and Shape:SolidMolecular weight:489.47BTK IN-1
CAS:BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).Formula:C19H21ClN6OPurity:97.38%Color and Shape:SolidMolecular weight:384.86Ref: TM-TQ0230
1mg38.00€2mg49.00€5mg80.00€10mg111.00€25mg180.00€50mg311.00€100mg439.00€1mL*10mM (DMSO)88.00€CGI-1746
CAS:CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Formula:C34H37N5O4Purity:97.69% - 97.88%Color and Shape:SolidMolecular weight:579.69Tolebrutinib
CAS:Tolebrutinib is an oral, selective BTK inhibitor, effective for MS research, with brain penetration and IC50s of 0.4/0.7 nM in cells.Formula:C26H25N5O3Purity:98.40% - 98.82%Color and Shape:SolidMolecular weight:455.51Ref: TM-T9125
2mg43.00€5mg74.00€10mg111.00€25mg187.00€50mg279.00€100mg459.00€200mg657.00€1mL*10mM (DMSO)85.00€evobrutinib
CAS:Evobrutinib(M2951) , also known as M-2951 and MSC-2364447C, is a highly selective inhibitor of the Bruton's tyrosine kinase (BTK), which is important in theFormula:C25H27N5O2Purity:99.01% - 99.58%Color and Shape:SolidMolecular weight:429.51Ref: TM-T4387
1mg42.00€5mg88.00€10mg127.00€25mg227.00€50mg329.00€100mg472.00€500mg1,017.00€1mL*10mM (DMSO)87.00€BMS-986142
CAS:BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).Formula:C32H30F2N4O4Purity:98.7% - 99.76%Color and Shape:SolidMolecular weight:572.6Ref: TM-T5138
1mg140.00€5mg378.00€10mg600.00€25mg939.00€50mg1,264.00€100mg1,691.00€200mg2,308.00€500mg3,410.00€1mL*10mM (DMSO)487.00€BTK-IN-40
CAS:BTK-IN-40 (compound 375) is an inhibitor of BTK.Formula:C20H25N7O2Color and Shape:SolidMolecular weight:395.46Remibrutinib
CAS:Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.Formula:C27H27F2N5O3Purity:99.5% - 99.81%Color and Shape:SolidMolecular weight:507.53Ref: TM-T16730
1mg97.00€5mg221.00€10mg359.00€25mg603.00€50mg753.00€100mg1,159.00€200mg1,568.00€1mL*10mM (DMSO)248.00€CNX-774
CAS:CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).Formula:C26H22FN7O3Purity:97.35% - 99.11%Color and Shape:SolidMolecular weight:499.5Ref: TM-T2302
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg235.00€50mg389.00€100mg567.00€500mg1,225.00€1mL*10mM (DMSO)93.00€Rilzabrutinib
CAS:Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).Formula:C36H40FN9O3Purity:97.87% - 99.76%Color and Shape:SolidMolecular weight:665.76Ref: TM-T12542
1mg99.00€5mg235.00€10mg376.00€25mg655.00€50mg944.00€100mg1,320.00€500mg2,642.00€1mL*10mM (DMSO)344.00€
