FAK
FAK (focal adhesion kinase) inhibitors target FAK, a kinase involved in cell adhesion, migration, and angiogenesis. FAK is frequently overexpressed in tumors and contributes to the formation of new blood vessels that supply nutrients to the tumor. Inhibiting FAK can disrupt these processes, making FAK inhibitors valuable tools in cancer therapy and angiogenesis research. At CymitQuimica, we provide a comprehensive range of high-quality FAK inhibitors to support your research in cell biology, cancer, and angiogenesis.
Products of "FAK"
Sort by
Found 50 products on this category.
Corosolic acid
CAS:Corosolic acid inhibits angiogenesis, suppresses FAK, fights various cancers, induces apoptosis, and degrades β-catenin.Formula:C30H48O4Purity:99.46% - 99.88%Color and Shape:Fine-Brown Yellow PowderMolecular weight:472.7FAK-IN-21
CAS:FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.Formula:C22H22F2N8O3SColor and Shape:SolidMolecular weight:516.52FAK-IN-12
FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM.Purity:98%Color and Shape:Odour SolidRoslin 2 bromide
CAS:Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Formula:C13H19BrN4Purity:97.07%Color and Shape:SolidMolecular weight:311.22Defactinib hydrochloride
CAS:Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Formula:C20H22ClF3N8O3SPurity:98.06% - 98.78%Color and Shape:SolidMolecular weight:546.95Ifebemtinib
CAS:Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formula:C28H28F4N6O4Purity:98.07% - 99.82%Color and Shape:SolidMolecular weight:588.55NAMI-A
CAS:NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Formula:C8H15Cl4N4ORuSPurity:98%Color and Shape:SolidMolecular weight:458.18AMP-945
CAS:AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.Formula:C28H32F3N5O2Purity:99.60%Color and Shape:SolidMolecular weight:527.58Ref: TM-T9576
1mg97.00€5mg188.00€10mg311.00€25mg533.00€50mg755.00€100mg1,035.00€1mL*10mM (DMSO)254.00€Adhesamine diTFA
CAS:Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.Formula:C28H32Cl2F6N8O6S2Color and Shape:SolidMolecular weight:825.63FAK-IN-7
CAS:FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.Formula:C16H13N3OSPurity:98.2%Color and Shape:SolidMolecular weight:295.36GSK2256098
CAS:GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.Formula:C20H23ClN6O2Purity:99.46% - 99.52%Color and Shape:SolidMolecular weight:414.89Ref: TM-T2281
1mg47.00€2mg60.00€5mg88.00€10mg137.00€25mg263.00€50mg449.00€100mg660.00€500mg1,388.00€1mL*10mM (DMSO)88.00€MY-1576
MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.Formula:C25H29ClN8O2Color and Shape:SolidMolecular weight:509PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formula:C23H25F3N6O2Purity:98%Color and Shape:SolidMolecular weight:474.48PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Formula:C25H26F3N5O3Purity:99.14% - 99.75%Color and Shape:SolidMolecular weight:501.5PF-573228
CAS:PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.Formula:C22H20F3N5O3SPurity:96.58% - 98.86%Color and Shape:SolidMolecular weight:491.49Anti-PTK2 Antibody (4T687)
Anti-PTK2 Antibody (4T687) is an antibody targeting PTK2. Anti-PTK2 Antibody (4T687) can be used in ELISA, IHC.Color and Shape:Odour LiquidNVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Formula:C23H25ClN6O3Purity:98.07% - 98.78%Color and Shape:SolidMolecular weight:468.94Ref: TM-T1918
1mg48.00€2mg63.00€5mg101.00€10mg163.00€25mg264.00€50mg378.00€100mg567.00€1mL*10mM (DMSO)101.00€FAK-IN-14
CAS:FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.Formula:C21H24BrN7OSPurity:99.7%Color and Shape:SoildMolecular weight:502.43PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Formula:C21H20F3N7O3SPurity:100% - 97.65%Color and Shape:SolidMolecular weight:507.49Ref: TM-T2465
1mg59.00€5mg127.00€10mg159.00€25mg240.00€50mg378.00€100mg567.00€200mg793.00€1mL*10mM (DMSO)140.00€Batatasin III
CAS:Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancerFormula:C15H16O3Purity:99.16%Color and Shape:SolidMolecular weight:244.29FAK-IN-15
FAK-IN-15 is a highly potent focal adhesion kinase (FAK) inhibitor with antitumor activity.Formula:C21H24ClN7OSPurity:99.08%Color and Shape:SolidMolecular weight:457.98Chloropyramine hydrochloride
CAS:Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.Formula:C16H20ClN3·HClPurity:99.45% - 99.8%Color and Shape:SolidMolecular weight:326.26Defactinib analogue-1
CAS:Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.Formula:C20H20F3N5O3SColor and Shape:SolidMolecular weight:467.47Conteltinib
CAS:Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formula:C32H45N9O3SPurity:98.12% - 99.54%Color and Shape:SolidMolecular weight:635.82Ref: TM-T14997
1mg77.00€5mg167.00€10mg240.00€25mg409.00€50mg572.00€100mg800.00€1mL*10mM (DMSO)227.00€PF-431396
CAS:PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).Formula:C22H21F3N6O3SPurity:98.83% - 99.82%Color and Shape:SolidMolecular weight:506.5Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purity:96.59% - 98.91%Color and Shape:SolidMolecular weight:383.82ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurity:98.27%Color and Shape:SolidMolecular weight:562.48Ref: TM-T10285
1mg52.00€5mg116.00€10mg170.00€25mg340.00€50mg472.00€100mg645.00€1mL*10mM (DMSO)143.00€FAK-IN-11
FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation.Formula:C25H41NO3Purity:98%Color and Shape:SolidMolecular weight:403.6Ifebemtinib hydrochloride
Ifebemtinib (BI-853520) hydrochloride is a potent FAK (focal adhesion kinase) inhibitor with oral bioavailability, exhibiting an IC50 of 1 nM for recombinant FAK. Ifebemtinib hydrochloride demonstrates antiproliferative activity against cancer cells.Formula:C28H29ClF4N6O4Color and Shape:SolidMolecular weight:625.01GSK215
CAS:GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.Formula:C50H59F3N10O6SPurity:99.3%Color and Shape:SoildMolecular weight:985.13PF-562271 hydrochloride
CAS:PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Formula:C21H20F3N7O3SHClPurity:98.52%Color and Shape:SolidMolecular weight:543.95Defactinib
CAS:Defactinib (VS-6063) is a second-generation inhibitor of FAK. Defactinib has potential antitumor activity. Cost-effective and quality-assured.Formula:C20H21F3N8O3SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:510.49ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Formula:C29H32FN3OColor and Shape:SolidMolecular weight:457.58Y15
CAS:Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,Formula:C6H14Cl4N4Purity:98% - 98%Color and Shape:Dark Brown CrystalsMolecular weight:284.01Ref: TM-T7119
10mg50.00€25mg69.00€50mg82.00€100mg137.00€200mg188.00€500mg331.00€1mL*10mM (DMSO)48.00€FAK activator 1
CAS:ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.Formula:C23H26F3N3O3Purity:98.85%Color and Shape:SoildMolecular weight:449.47Ref: TM-T77665
1mg99.00€5mg229.00€10mg383.00€25mg627.00€50mg1,005.00€100mg1,589.00€200mg2,078.00€1mL*10mM (DMSO)296.00€Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formula:C28H30N6OSPurity:100% - 99.55%Color and Shape:SolidMolecular weight:498.642119738-71-3
CAS:Compound 2119738-71-3 interacts with the FAK receptor.Formula:C25H29ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:513.99Compound 1T-0219 (SC)
CAS:Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620Formula:C20H19N3O7Purity:90%Color and Shape:SolidMolecular weight:413.38ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formula:C23H28ClN7O3SPurity:99% - 99.77%Color and Shape:SolidMolecular weight:518.03(R)-Fangchinoline
CAS:(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.Formula:C37H40N2O6Purity:98% - 99.72%Color and Shape:SolidMolecular weight:608.72FAK inhibitor 7
CAS:FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.Formula:C32H37N7O3Color and Shape:SolidMolecular weight:567.68PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Formula:C21H20F3N7O3S·C6H6O3SPurity:97.65% - 99.01%Color and Shape:SolidMolecular weight:665.66Ref: TM-T6177
1mg38.00€5mg79.00€10mg88.00€25mg145.00€50mg210.00€100mg313.00€200mg452.00€1mL*10mM (DMSO)95.00€FAK-IN-10
CAS:FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.Formula:C15H10BrN3O2SPurity:99.78%Color and Shape:SoildMolecular weight:376.23BI-4464
CAS:BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTACFormula:C28H28F3N5O4Purity:97.43%Color and Shape:SolidMolecular weight:555.55SU6656
CAS:SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.Formula:C19H21N3O3SPurity:97% - 98.21%Color and Shape:SolidMolecular weight:371.45Ref: TM-T6997
1mg40.00€2mg51.00€5mg85.00€10mg139.00€25mg269.00€50mg449.00€100mg667.00€1mL*10mM (DMSO)88.00€Fangchinoline
CAS:Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.Formula:C37H40N2O6Purity:98.81% - 99.86%Color and Shape:SolidMolecular weight:608.72OXA-11
CAS:OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.Formula:C37H49F3N7O5PPurity:98.70% - 99.20%Color and Shape:SolidMolecular weight:759.8Si306
CAS:Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).Formula:C25H26BrClN6OSColor and Shape:SolidMolecular weight:573.94Ifebemtinib FA
BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.Formula:C29H30F4N6O6Purity:98.40% - 99.62%Color and Shape:SolidMolecular weight:634.58CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formula:C30H38ClN7O3Purity:98.86% - 99.98%Color and Shape:SolidMolecular weight:580.12
