TNF
TNF (Tumor Necrosis Factor) inhibitors are compounds that block the activity of TNF, a cytokine involved in inflammation and the regulation of apoptosis. TNF can induce apoptosis in some cell types while promoting survival and inflammation in others. Inhibiting TNF is crucial in the treatment of autoimmune diseases, chronic inflammatory conditions, and certain cancers. TNF inhibitors help to modulate the immune response and reduce tissue damage caused by excessive inflammation. At CymitQuimica, we provide a diverse range of high-quality TNF inhibitors to support your research in immunology, inflammation, and apoptosis.
Products of "TNF"
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Belantamab
CAS:Belantamab (GSK2857914) is a humanized IgG1 monoclonal antibody targeting BCMA, used for creating conjugates like mafodotin.Purity:SDS-PAGE:95% SEC-HPLC:99.99%Color and Shape:LiquidMolecular weight:146.06 kDa(S,S)-TAPI-1 FA
(S,S)-TAPI-1 FA is a TNF-α processing inhibitor with potential anti-inflammatory effects, blocks TACE, and can inhibit TNF-α signaling can be used to study Staphylococcus aureus arthritis.Formula:C27H39N5O7Purity:98.30% - 99.15%Color and Shape:SolidMolecular weight:545.63TNF α Protein, Human, Recombinant (His & Avi), Biotinylated
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:20.3 kDa (predicted). Due to glycosylation, the protein migrates to 21-24 kDa based on Tris-Bis PAGE result.Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purity:94.14% - 98.31%Color and Shape:Yellow To Brown Crystalline PowderMolecular weight:286.24C25-140
CAS:C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.Formula:C26H31N7OPurity:98.81%Color and Shape:SolidMolecular weight:457.57Hederacoside D
CAS:Hederacoside D is a bioactive saponins from Hedera helix.Formula:C53H86O22Purity:94.94% - 99.30%Color and Shape:SolidMolecular weight:1075.24SPD304 dihydrochloride
CAS:SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.Formula:C32H34Cl2F3N3O2Purity:99.25%Color and Shape:SolidMolecular weight:620.53Etanercept
CAS:Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.Purity:98%Color and Shape:LiquidAtibuclimab
CAS:Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.28 kDaEupatolide
CAS:Eupatolide, from Inula japonica flowers, has anti-inflammatory properties and aids in researching TRAIL resistance in breast cancer.Formula:C15H20O3Purity:98%Color and Shape:SolidMolecular weight:248.32Alethine
CAS:Alethine is a small antitumor compound used to treat cancers and infections, boosting T-cell cytotoxicity by raising TNFα.Formula:C10H22N4O2S2Purity:98.82%Color and Shape:SolidMolecular weight:294.44RIPK-IN-4
CAS:RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).Formula:C18H21FN4O3SPurity:98%Color and Shape:SolidMolecular weight:392.45Forsythoside B
CAS:Forsythoside B inhibits LPS, NF-κB, inflammation, offers neuroprotection, reduces ischemia injury, and has antioxidant and antisepsis effects.Formula:C34H44O19Purity:98% - 98.78%Color and Shape:SolidMolecular weight:756.7(R)-STU104
CAS:(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.Formula:C18H18O4Purity:98.91% - 99.42%Color and Shape:SolidMolecular weight:298.33Tebentafusp
CAS:Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.Color and Shape:LiquidEJMC-1
CAS:EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.Formula:C17H11ClN2O4SPurity:97.69%Color and Shape:SolidMolecular weight:374.8Ref: TM-T60054
1mg144.00€2mg208.00€5mg351.00€10mg500.00€25mg730.00€50mg998.00€100mg1,349.00€500mg2,707.00€4-methoxylonchocarpin
CAS:4-methoxylonchocarpin, from Abrus precatorius roots, inhibits NF-κB, LPS/TLR4 in macrophages, and mouse colitis.Formula:C21H20O4Purity:98%Color and Shape:SoildMolecular weight:336.38Mulberroside A
CAS:1.Formula:C26H32O14Purity:99.05% - 99.4%Color and Shape:SolidMolecular weight:568.52Ref: TM-T6S1597
1mg49.00€5mg90.00€10mg144.00€25mg254.00€50mg424.00€100mg613.00€1mL*10mM (DMSO)114.00€QNZ
CAS:QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.Formula:C22H20N4OPurity:98.16% - 99.17%Color and Shape:White SolidMolecular weight:356.42Ref: TM-T6204
1mg43.00€2mg57.00€5mg93.00€10mg140.00€25mg226.00€50mg329.00€100mg490.00€1mL*10mM (DMSO)93.00€Certolizumab pegol
CAS:Certolizumab pegol (Certolizumab) is a polyethylene glycolized and humanized anti-TNF-α monoclonal antibody.Color and Shape:LiquidDacetuzumab
CAS:Dacetuzumab (SGN 40) is a humanized anti-CD40 monoclonal antibody with antitumor activity for the study of recurrent diffuse large B-cell lymphoma.Purity:95% - 95%Color and Shape:LiquidMitazalimab
CAS:Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.Purity:95% - 95%Color and Shape:LiquidGNE684
CAS:GNE684 inhibits RIP1; Ki app: 21 nM (human), 189 nM (mouse), 691 nM (rat).Formula:C23H24N6O3Purity:98%Color and Shape:SolidMolecular weight:432.48Ragifilimab
CAS:Ragifilimab (INCAGN-1876), a GITR-targeting agonist antibody, may treat advanced solid tumors.Purity:SDS-PAGE:95% SEC-HPLC:99.99%Color and Shape:LiquidMolecular weight:146.46 kDaPK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formula:C22H24N4O3SPurity:98.09% - 98.13%Color and Shape:SolidMolecular weight:424.52Ref: TM-T12493
1mg86.00€5mg170.00€10mg274.00€25mg520.00€50mg750.00€100mg1,026.00€200mg1,388.00€1mL*10mM (DMSO)188.00€CPI1189
CAS:CPI1189 (REN-1189) is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.Formula:C13H18N2O2Purity:98.87% - 99.68%Color and Shape:SolidMolecular weight:234.291-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
CAS:1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea 是一种能够激动 TNF-α的化合物,可以诱导细胞分泌 TNF-α。Formula:C24H21ClF3N5OPurity:97.90% - 98.61%Color and Shape:SoildMolecular weight:487.9Sotigalimab
CAS:Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.Purity:95% - 95%Color and Shape:LiquidEnavatuzumab
CAS:Enavatuzumab (PDL192) is a humanized monoclonal antibody targeting TWEAK receptor with anti-tumor activity.Purity:>95%Color and Shape:LiquidInfliximab
CAS:Infliximab is a chimeric monoclonal antibody that inhibits TNF-α. Infliximab can be used to treat Crohn's disease and rheumatoid arthritis. Cost-effective and quality-assured.Purity:98% - 99.70%Color and Shape:LiquidMolecular weight:149 kDaTNF α Protein, Human, Recombinant (aa 57-233, His)
TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E.Color and Shape:Lyophilized PowderMolecular weight:18 KDa (reducing condition)Roquinimex
CAS:Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis andFormula:C18H16N2O3Purity:97.69%Color and Shape:SolidMolecular weight:308.33Ref: TM-T4412
2mg44.00€5mg65.00€10mg96.00€25mg167.00€50mg283.00€100mg454.00€200mg648.00€1mL*10mM (DMSO)72.00€TNF-α-IN-1
CAS:TNF-α-IN-1 is a TNF-α inhibitor.Formula:C16H14ClN3O5Purity:98%Color and Shape:SolidMolecular weight:363.75Resatorvid
CAS:Resatorvid (TAK-242) inhibits TLR4, with IC50s for IL-6, TNF-R, NO at 1.3, 1.9, 1.8 nM respectively.Formula:C15H17ClFNO4SPurity:100% - 99.9%Color and Shape:SolidMolecular weight:361.82Ref: TM-TQ0181
1mg49.00€2mg70.00€5mg96.00€10mg164.00€25mg306.00€50mg502.00€100mg805.00€1mL*10mM (DMSO)116.00€L6H21
CAS:L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.Formula:C18H18O4Purity:99.26%Color and Shape:SolidMolecular weight:298.33VU0285655-1
CAS:VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.Formula:C25H27N5O2Purity:99.73%Color and Shape:SolidMolecular weight:429.51TNF α Protein, Ferret, Recombinant (His)
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E.Color and Shape:Lyophilized PowderMolecular weight:18.88 kDa (predicted) same as Tris-Bis PAGE result.TNF α Protein, Human, Recombinant (aa 77-233, His)
TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E.Purity:Greater than 95% as determined by reducing SDS-PAGE - SDS-PAGE: 99.66%; SEC-HPLC: 96.3%Color and Shape:Lyophilized PowderMolecular weight:16 KDa (reducing condition)Hernandezine
CAS:Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.Formula:C39H44N2O7Purity:99.53%Color and Shape:SolidMolecular weight:652.78Kdo2-Lipid A ammonium
CAS:Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.Formula:C110H214N6O39P2Purity:98%Color and Shape:SolidMolecular weight:2306.84Tilogotamab
CAS:Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).Purity:95%Color and Shape:LiquidUCB-9260
CAS:UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.Formula:C26H25N5OPurity:98.39% - 99.24%Color and Shape:SolidMolecular weight:423.51Trifolirhizin
CAS:Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Formula:C22H22O10Purity:98% - 99.67%Color and Shape:SolidMolecular weight:446.4HS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Formula:C17H16N4O3Purity:97.34%Color and Shape:SolidMolecular weight:324.33Varlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Purity:SDS-PAGE:95% SEC-HPLC:98.65%Color and Shape:LiquidMolecular weight:146 kDaUCB-5307
CAS:UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.Formula:C22H21N3OPurity:98.02%Color and Shape:SolidMolecular weight:343.42LASSBio-1135
CAS:LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Formula:C18H14N4Purity:99.09%Color and Shape:SolidMolecular weight:286.33C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Formula:C24H15ClN6O3SPurity:≥98%Color and Shape:SolidMolecular weight:502.93Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Formula:C26H25Cl2FN8Purity:98.87%Color and Shape:SolidMolecular weight:539.43Ref: TM-T10866
1mg74.00€5mg165.00€10mg255.00€25mg537.00€50mg753.00€100mg1,074.00€200mg1,444.00€1mL*10mM (DMSO)190.00€Belimumab
CAS:Belimumab, a human IgG1λ monoclonal antibody, blocks BAFF, treating lupus and related fatigue.Purity:SDS-PAGE:98.4%;SEC-HPLC:98.4%Color and Shape:LiquidMolecular weight:144.07 kDa
