Mdm2
Mdm2 inhibitors target the Mdm2 protein, which is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53. Mdm2 promotes the degradation of p53, thereby preventing apoptosis in cells that should undergo cell death. Inhibiting Mdm2 stabilizes p53, enhancing its tumor-suppressing activity and promoting apoptosis in cancer cells. Mdm2 inhibitors are crucial in cancer research and therapy, particularly for cancers with intact p53 pathways. At CymitQuimica, we provide high-quality Mdm2 inhibitors to support your research in cancer biology, apoptosis, and therapeutic development.
Products of "Mdm2"
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Found 34 products on this category.
Alrizomadlin
CAS:Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.Formula:C34H38Cl2FN3O4Purity:98.69% - 98.79%Color and Shape:SolidMolecular weight:642.59Ref: TM-T14303
1mg52.00€5mg111.00€10mg180.00€25mg359.00€50mg588.00€100mg944.00€200mg1,264.00€1mL*10mM (DMSO)159.00€NVP-CGM097
CAS:NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).Formula:C38H47ClN4O4Purity:98.77%Color and Shape:SolidMolecular weight:659.26Ref: TM-TQ0231
1mg87.00€5mg207.00€10mg341.00€25mg520.00€50mg682.00€100mg944.00€1mL*10mM (DMSO)300.00€RO-5963
CAS:RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).Formula:C24H21ClF2N4O5Purity:98%Color and Shape:SolidMolecular weight:518.9Ref: TM-T16771
1mg70.00€5mg197.00€10mg284.00€25mg434.00€50mg562.00€100mg780.00€200mg1,035.00€1mL*10mM (DMSO)224.00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurity:100% - 97.71%Color and Shape:SolidMolecular weight:454.63Ref: TM-T1818
1mg43.00€2mg56.00€5mg77.00€10mg87.00€25mg157.00€50mg230.00€100mg393.00€500mg930.00€1mL*10mM (DMSO)79.00€MB710
CAS:MB710 is an amino-benzothiazole derivative that tightly binds to the Y220C pocket and stabilizes p53-Y220C in vitro.Formula:C16H16IN3O3SPurity:99.02%Color and Shape:SolidMolecular weight:457.29Nutlin-3b
CAS:Nutlin-3b, a less potent (+)-enantiomer of Nutlin-3, inhibits p53/MDM2 at IC50: 13.6 μM, 150x weaker than Nutlin-3a.Formula:C30H30Cl2N4O4Purity:98.83%Color and Shape:SolidMolecular weight:581.49Ref: TM-T6614
1mg42.00€2mg55.00€5mg88.00€10mg137.00€25mg255.00€50mg424.00€100mg612.00€1mL*10mM (DMSO)97.00€PhiKan 083
CAS:PhiKan 083 is a carbazole derivativeFormula:C16H18N2Purity:98.37%Color and Shape:SolidMolecular weight:238.33Ref: TM-T16523L
1mg35.00€5mg70.00€10mg111.00€25mg235.00€50mg329.00€100mg464.00€500mg1,008.00€1mL*10mM (DMSO)75.00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09Ref: TM-T8480
1mg39.00€2mg51.00€5mg70.00€10mg88.00€25mg140.00€50mg226.00€100mg376.00€1mL*10mM (DMSO)73.00€NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Formula:C23H20N2OPurity:96.94%Color and Shape:SolidMolecular weight:340.42RG7112
CAS:RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.Formula:C38H48Cl2N4O4SPurity:99.17% - 99.92%Color and Shape:SolidMolecular weight:727.78Ref: TM-T6965
1mg48.00€2mg65.00€5mg96.00€10mg169.00€25mg325.00€50mg495.00€100mg718.00€500mg1,501.00€1mL*10mM (DMSO)155.00€Kevetrin hydrochloride
CAS:Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potentialFormula:C5H10ClN3SPurity:99.32% - 99.93%Color and Shape:SolidMolecular weight:179.67MA242
CAS:MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).Formula:C26H21ClF3N3O5SPurity:98%Color and Shape:SolidMolecular weight:579.98UC2288
CAS:UC2288, a Sorafenib-based p21 attenuator, reduces p21 levels without affecting its stability.Formula:C20H18ClF6N3O2Purity:99.75%Color and Shape:SolidMolecular weight:481.82Ref: TM-T9698
1mg48.00€5mg96.00€10mg144.00€25mg263.00€50mg393.00€100mg487.00€200mg607.00€500mg882.00€1mL*10mM (DMSO)96.00€Navtemadlin
CAS:Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM).Cost-effective and quality-assured.Formula:C28H35Cl2NO5SPurity:95.55% - 98.86%Color and Shape:SolidMolecular weight:568.55MI-1061
CAS:MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).Formula:C30H26Cl2FN3O4Color and Shape:SolidMolecular weight:582.45AM-8735
CAS:AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).Formula:C27H31Cl2NO6SPurity:98%Color and Shape:SolidMolecular weight:568.51Amifostine thiol
CAS:Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.Formula:C5H14N2SPurity:≥95.0%Color and Shape:SolidMolecular weight:134.24Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.48Idasanutlin
CAS:Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).Formula:C31H29Cl2F2N3O4Purity:98.85% - 99.86%Color and Shape:SolidMolecular weight:616.48Ref: TM-T6254
2mg40.00€5mg60.00€10mg96.00€25mg159.00€50mg226.00€100mg376.00€500mg883.00€1mL*10mM (DMSO)84.00€RITA
CAS:RITA (NSC-652287) forms DNA-DNA/protein cross-links without DNA breaks; disrupts p53/Mdm2 like nutlin-3.Formula:C14H12O3S2Purity:97.76% - 98.85%Color and Shape:SolidMolecular weight:292.37Ref: TM-T1798
1mg35.00€2mg46.00€5mg66.00€10mg96.00€25mg188.00€50mg344.00€100mg509.00€200mg715.00€500mg1,093.00€1mL*10mM (DMSO)89.00€SAR405838
CAS:MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.Formula:C29H34Cl2FN3O3Purity:98.04%Color and Shape:SolidMolecular weight:562.5Ref: TM-T6585
1mg49.00€2mg90.00€5mg133.00€10mg213.00€25mg419.00€50mg617.00€100mg879.00€500mg1,776.00€p53-MDM2-IN-1
CAS:p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM.Formula:C23H20ClN3O3Purity:98.3%Color and Shape:SoildMolecular weight:421.88SJ-172550
CAS:SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).Formula:C22H21ClN2O5Purity:99.87%Color and Shape:SolidMolecular weight:428.87Ref: TM-T16888
2mg44.00€5mg65.00€10mg96.00€25mg185.00€50mg354.00€100mg607.00€500mg1,264.00€1mL*10mM (DMSO)72.00€SP-141
CAS:SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.Formula:C22H16N2OPurity:98.01%Color and Shape:SolidMolecular weight:324.38MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Formula:C41H42Cl2FN5O5Purity:98%Color and Shape:SolidMolecular weight:774.71PK11007
CAS:PK11007 is an anti-p53 drug.Formula:C15H11ClFN5O3S2Purity:≥98%Color and Shape:SolidMolecular weight:427.86p53-Mdm2 inhibitor 4
CAS:p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.Formula:C23H20FN3O3Purity:99.63%Color and Shape:SoildMolecular weight:405.42RO8994
CAS:RO8994: potent MDM2 spiroindolinone inhibitor, IC50: 20 nM (proliferation), 5 nM (binding).Formula:C31H31Cl2FN4O4Purity:99.31% - 99.44%Color and Shape:SolidMolecular weight:613.51Ref: TM-T3517
1mg40.00€2mg52.00€5mg87.00€10mg127.00€25mg230.00€50mg364.00€100mg540.00€1mL*10mM (DMSO)105.00€Milademetan
CAS:Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formula:C30H34Cl2FN5O4Purity:100%Color and Shape:SolidMolecular weight:618.53Ref: TM-T12040
1mg170.00€5mg518.00€10mg753.00€25mg1,035.00€50mg1,454.00€100mg1,882.00€1mL*10mM (DMSO)35.00€MX69
CAS:MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.Formula:C27H26N2O4SPurity:97.27% - 99.57%Color and Shape:SolidMolecular weight:474.57Ref: TM-T3653
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg227.00€50mg368.00€100mg547.00€500mg1,198.00€1mL*10mM (DMSO)82.00€XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Formula:C11H13N5O4Purity:99.12%Color and Shape:SolidMolecular weight:279.25Ref: TM-T6610
1mg56.00€2mg81.00€5mg119.00€10mg187.00€25mg432.00€50mg638.00€100mg908.00€500mg1,825.00€1mL*10mM (DMSO)114.00€MD-224
CAS:MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.Formula:C48H43Cl2FN6O6Purity:100% - 99.07%Color and Shape:SolidMolecular weight:889.8Ref: TM-T11980
1mg70.00€5mg153.00€10mg274.00€25mg467.00€50mg655.00€100mg932.00€200mg1,283.00€1mL*10mM (DMSO)166.00€Brigimadlin
CAS:Brigimadlin (BI 907828) is an orally active and highly potent antagonist of the E3 ubiquitin-protein ligase MDM2-p53 with antitumor activity.Formula:C31H25Cl2FN4O3Purity:98.17%Color and Shape:SolidMolecular weight:591.46CP-31398 dihydrochloride
CAS:CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines.Formula:C22H28Cl2N4OPurity:98.23%Color and Shape:SolidMolecular weight:435.4Ref: TM-T21648
5mg49.00€10mg74.00€25mg134.00€50mg207.00€100mg339.00€200mg470.00€1mL*10mM (DMSO)58.00€
