PERK
PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) inhibitors target the PERK pathway, which is involved in the cellular response to endoplasmic reticulum (ER) stress and the regulation of apoptosis. PERK plays a critical role in the unfolded protein response (UPR) by halting protein translation and promoting cell survival under stress conditions. However, prolonged PERK activation can lead to apoptosis. Inhibiting PERK can modulate these stress responses, making these inhibitors valuable in research on neurodegenerative diseases, cancer, and metabolic disorders. At CymitQuimica, we offer a range of high-quality PERK inhibitors to support your research in apoptosis, ER stress, and cellular homeostasis.
Products of "PERK"
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ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Formula:C25H28N2O5S2Purity:97.82%Color and Shape:SolidMolecular weight:500.634E1rcat
CAS:4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.Formula:C28H18N2O6Purity:99.36%Color and Shape:SolidMolecular weight:478.45Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurity:98.27%Color and Shape:SolidMolecular weight:547.99Ref: TM-T22436
1mg97.00€2mg135.00€5mg188.00€10mg283.00€25mg462.00€50mg645.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)255.00€GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurity:100% - 99.89%Color and Shape:SolidMolecular weight:416.45Ref: TM-T2654
2mg35.00€5mg50.00€10mg81.00€25mg142.00€50mg259.00€100mg467.00€200mg632.00€1mL*10mM (DMSO)56.00€GCN2-IN-7
CAS:GCN2-IN-7 is an inhibitor of the environmental sensing protein GCN2 with antitumor activity for the study of melanoma.Formula:C22H23BrN8OSPurity:99.12%Color and Shape:SolidMolecular weight:527.44HC-5404-Fu
CAS:HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Formula:C28H28F2N4O7Color and Shape:SolidMolecular weight:570.54Bufotalin
CAS:1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.Formula:C26H36O6Purity:99.45% - 99.67%Color and Shape:White To Off-White SolidMolecular weight:444.56Ref: TM-T5A2461
1mg48.00€5mg96.00€10mg144.00€25mg235.00€50mg349.00€100mg515.00€500mg1,103.00€1mL*10mM (DMSO)96.00€eIF4A3-IN-1
CAS:eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.Formula:C29H23BrClN5O2Purity:99.49%Color and Shape:SolidMolecular weight:588.88GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Formula:C19H12Cl2F2N4O3SPurity:95.04% - 97.97%Color and Shape:SolidMolecular weight:485.29ISRIB
CAS:ISRIB is a potent and selective PERK inhibitor.Formula:C22H24Cl2N2O4Purity:97.69% - ≥95%Color and Shape:SolidMolecular weight:451.34BAY 2965501
CAS:BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.Formula:C20H19FN4O3SPurity:99.4%Color and Shape:SolidMolecular weight:414.45SBI-0640756
CAS:SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.Formula:C23H14ClFN2O2Purity:99.75%Color and Shape:SolidMolecular weight:404.82Ref: TM-T5173
1mg39.00€5mg87.00€10mg140.00€25mg271.00€50mg386.00€100mg540.00€200mg735.00€1mL*10mM (DMSO)93.00€IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formula:C17H18Cl2N6Purity:98.80%Color and Shape:SolidMolecular weight:377.27ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formula:C22H24Cl2N2O4Purity:97.86% - 99.27%Color and Shape:SolidMolecular weight:451.34PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formula:C23H22N6OPurity:98.77% - 99.78%Color and Shape:SolidMolecular weight:398.46ATPγS tetralithium salt
CAS:ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.Cost-effective and quality-assured.Formula:C10H12Li4N5O12P3SPurity:90% - ≥98%Color and Shape:White PowderMolecular weight:546.98GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase(PERK)inhibitor.Cost-effective and quality-assured.Formula:C24H20F3N5OPurity:100% - 98.63%Color and Shape:SolidMolecular weight:451.44PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurity:100% - 98.14%Color and Shape:SolidMolecular weight:469.43HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formula:C24H24F2N4O3Purity:99.33%Color and Shape:SolidMolecular weight:454.47DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Formula:C20H19ClF3N3O4Purity:100%Color and Shape:SolidMolecular weight:457.83
