Caspase
Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.
Products of "Caspase"
Sort by
Z-DEVD-FMK
CAS:Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7,Formula:C30H41FN4O12Purity:96.19% - 99.69%Color and Shape:SolidMolecular weight:668.66Almorexant
CAS:Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.Formula:C29H31F3N2O3Purity:97.75% - 98.02%Color and Shape:SolidMolecular weight:512.56Ac-DEVD-AMC
CAS:Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .Formula:C30H37N5O13Purity:98.20%Color and Shape:White PowderMolecular weight:675.6415-Acetoxyscirpenol
CAS:15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.Formula:C17H24O6Purity:98%Color and Shape:SolidMolecular weight:324.373ZYZ-488
CAS:ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.Formula:C20H29N3O11Purity:99.04%Color and Shape:SolidMolecular weight:487.46Ac-VAD-CHO
CAS:Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release ofFormula:C14H23N3O6Purity:98%Color and Shape:SolidMolecular weight:329.35Emricasan
CAS:Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties.Formula:C26H27F4N3O7Purity:98.13% - 99%Color and Shape:SolidMolecular weight:569.5Ref: TM-T6826
1mg44.00€2mg58.00€5mg95.00€10mg144.00€25mg254.00€50mg419.00€100mg617.00€1mL*10mM (DMSO)107.00€Duocarmycin A
CAS:Duocarmycin A: an antitumor DNA alkylator targeting adenine; induces apoptosis in HLC-2 cells.Formula:C26H25N3O8Purity:98%Color and Shape:SolidMolecular weight:507.49Z-YVAD-FMK
CAS:AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.Formula:C31H39FN4O9Purity:98.00%Color and Shape:SolidMolecular weight:630.66Ac-VEID-AFC
Ac-VEID-AFC is a fluorogenic substrate for caspase-6, utilized in caspase-6 activity assays [1].Formula:C32H39F3N4O12Purity:98%Color and Shape:SolidMolecular weight:728.67M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFormula:C28H45N7O6Purity:98%Color and Shape:SolidMolecular weight:575.7PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purity:98.82%Color and Shape:SolidMolecular weight:394.47Biotin-VAD-FMK
CAS:Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates.Formula:C30H49FN6O8SColor and Shape:SolidMolecular weight:672.812-HBA
CAS:2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.Formula:C17H14O3Purity:99.76%Color and Shape:SolidMolecular weight:266.29Ref: TM-T7374
2mg35.00€5mg52.00€10mg80.00€25mg144.00€50mg225.00€100mg359.00€200mg532.00€1mL*10mM (DMSO)58.00€Ref: TM-T5S2358
1mg57.00€2mg81.00€5mg111.00€10mg160.00€25mg263.00€50mg378.00€100mg558.00€200mg797.00€1mL*10mM (DMSO)123.00€Effusol
CAS:Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values of 79 μM and 2.73 μM, respectively).Formula:C17H16O2Purity:99.67%Color and Shape:SolidMolecular weight:252.31EF24
CAS:EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.Formula:C19H15F2NOPurity:98.47%Color and Shape:SolidMolecular weight:311.33Ref: TM-T27242
1g1,510.00€1mg40.00€5mg85.00€10mg133.00€25mg235.00€50mg354.00€100mg533.00€500mg1,130.00€1mL*10mM (DMSO)93.00€Sesamolin
CAS:Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.Formula:C20H18O7Purity:98.77% - 99.04%Color and Shape:SolidMolecular weight:370.35Ref: TM-T5S2283
1mg40.00€5mg85.00€10mg135.00€25mg216.00€50mg324.00€100mg472.00€500mg1,026.00€1mL*10mM (DMSO)88.00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Dehydrotrametenolic acid
CAS:Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation inFormula:C31H48O3Purity:98%Color and Shape:SolidMolecular weight:468.71Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16Tauroursodeoxycholate sodium
CAS:Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.Formula:C26H44NNaO6SPurity:97.90%Color and Shape:SolidMolecular weight:521.69Fenbufen
CAS:Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.Formula:C16H14O3Purity:98.35% - 98.46%Color and Shape:White SolidMolecular weight:254.28AVN-944
CAS:AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.Formula:C25H27N5O5Purity:99.07% - ≥95%Color and Shape:SolidMolecular weight:477.51δ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Formula:C10H12N4O2Purity:99.4%Color and Shape:SolidMolecular weight:220.23Ginsenoside Rh2
CAS:Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.Formula:C36H62O8Purity:99.20% - 99.76%Color and Shape:White PowderMolecular weight:622.87(Iso)-Z-VAD(OMe)-FMK
CAS:(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formula:C22H30FN3O7Purity:97.10%Color and Shape:SoildMolecular weight:467.49BRD-810
BRD-810, a highly selective MCL1 inhibitor, binds to the MCL1 BH3 groove, impeding the sequestration of pro-apoptotic proteins and swiftly triggering caspase activation in MCL1-dependent cell lines. This compound exhibits anti-tumor efficacy in both blood cancer and solid tumor models.Formula:C39H44ClFN4O5Color and Shape:SolidMolecular weight:703.24Ossirene
CAS:Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.Formula:C2H4Cl3O2Te·H4NPurity:≥95%Color and Shape:SolidMolecular weight:312.05Dehydrocorydaline chloride
CAS:Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.Formula:C22H24ClNO4Purity:99.53%Color and Shape:SolidMolecular weight:401.88Ref: TM-T10990
1mg58.00€5mg111.00€10mg160.00€25mg264.00€50mg396.00€100mg563.00€1mL*10mM (DMSO)124.00€Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purity:96.66%Color and Shape:SolidMolecular weight:332.39Diclofenac Potassium
CAS:Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.Formula:C14H10Cl2KNO2Purity:99.51%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:334.24Diclofenac diethylamine
CAS:Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).Formula:C18H22Cl2N2O2Purity:99.81% - 99.87%Color and Shape:SolidMolecular weight:369.29Z-IETD-FMK
CAS:Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.Formula:C30H43FN4O11Purity:95% - 99.81%Color and Shape:SolidMolecular weight:654.68Ref: TM-T7019
1mg125.00€2mg182.00€5mg263.00€10mg420.00€25mg682.00€50mgTo inquire1mL*10mM (DMSO)408.00€(2R,3S)-Emricasan
CAS:(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.Formula:C26H27F4N3O7Color and Shape:SolidMolecular weight:569.5Boc-Asp(OMe)-fluoromethyl ketone
CAS:Boc-Asp(OMe)-FMK is a broad-spectrum caspase inhibitor that blocks Fas-mediated processes without affecting IL-8 chemotaxis.Formula:C11H18FNO5Purity:≥98%Color and Shape:SolidMolecular weight:263.26M190S
CAS:M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.Formula:C21H21N5O2Purity:98%Color and Shape:SolidMolecular weight:375.42Ivachtin
CAS:Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remainingFormula:C20H21N3O7SPurity:98.17%Color and Shape:SolidMolecular weight:447.46Anisperimus
CAS:Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.Formula:C18H39N7O3Purity:98.10%Color and Shape:SolidMolecular weight:401.55ML-9
CAS:ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.Formula:C15H18Cl2N2O2SPurity:99.69%Color and Shape:Crystalline SolidMolecular weight:361.29Cystamine
CAS:Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM.Formula:C4H12N2S2Purity:99.41%Color and Shape:SolidMolecular weight:152.28Wedelolactone
CAS:Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.Formula:C16H10O7Purity:98.07% - 99.76%Color and Shape:SolidMolecular weight:314.25Ref: TM-T3384
1mg35.00€5mg74.00€10mg115.00€25mg185.00€50mg331.00€100mg437.00€500mg1,008.00€1mL*10mM (DMSO)52.00€Z-VEID-AFC
CAS:Z-VEID-AFC is a caspase-6 fluorescent substrate [1].Formula:C38H44F3N5O12Purity:98%Color and Shape:SolidMolecular weight:819.78TC11
CAS:TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFormula:C20H22N2O2Purity:97.86%Color and Shape:SolidMolecular weight:322.4Oxidopamine hydrobromide
CAS:Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.Formula:C8H12BrNO3Purity:98.1% - 99.88%Color and Shape:Beige To Brown Fine Crystalline PowderMolecular weight:250.09Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14Aristolactam I
CAS:Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway.Formula:C17H11NO4Purity:98.98% - 99.63%Color and Shape:SolidMolecular weight:293.27Ref: TM-T3S1227
1mg60.00€5mg140.00€10mg216.00€25mg369.00€50mg545.00€100mg775.00€1mL*10mM (DMSO)175.00€AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.Formula:C17H14N6Purity:97.3%Color and Shape:SolidMolecular weight:302.33CIL62
CAS:CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].Formula:C23H26O5Purity:97.07%Color and Shape:SolidMolecular weight:382.45Ref: TM-T8468
1mg52.00€5mg116.00€10mg170.00€25mg335.00€50mg562.00€100mg758.00€200mg1,017.00€1mL*10mM (DMSO)128.00€
