BCL
BCL inhibitors are compounds that target the BCL-2 family of proteins, which play a key role in the regulation of apoptosis. The BCL-2 family includes both pro-apoptotic and anti-apoptotic members that control the mitochondrial pathway of apoptosis. Inhibiting anti-apoptotic BCL-2 proteins can promote cell death in cancer cells, making BCL inhibitors crucial in cancer therapy research. At CymitQuimica, we provide a comprehensive selection of high-quality BCL inhibitors to support your research in cancer, apoptosis, and cell biology.
Products of "BCL"
Sort by
Found 32 products on this category.
PROTAC Bcl2 degrader-1
CAS:PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Formula:C45H45BrN6O10SPurity:98%Color and Shape:SolidMolecular weight:941.84S55746 hydrochloride
CAS:S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.Formula:C43H43ClN4O6Purity:98%Color and Shape:SolidMolecular weight:747.28Tanshinone IIB
CAS:TSB reduces DNA damage, cytotoxicity, and apoptosis in rat neurons, balances Bax, bcl-2, caspase-3 proteins, and has potential for treating stroke.Formula:C19H18O4Purity:98%Color and Shape:SolidMolecular weight:310.349Crenulatin
CAS:Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/LFormula:C11H20O6Purity:98%Color and Shape:SolidMolecular weight:248.275Obovatol
CAS:Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's diseaseFormula:C18H18O3Purity:98%Color and Shape:SolidMolecular weight:282.33Isolimonexic acid
CAS:Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.Formula:C26H30O10Purity:98%Color and Shape:SolidMolecular weight:502.51Ferruginol
CAS:Ferruginol exhibits anti-cancer, anti-inflammatory, cardioprotective properties and can trigger NSCLC cell apoptosis.Formula:C20H30OPurity:98%Color and Shape:SolidMolecular weight:286.459Metaproterenol
CAS:Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).Formula:C11H17NO3Purity:98%Color and Shape:SolidMolecular weight:211.26Panaxynol
CAS:Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.Formula:C17H24OPurity:98%Color and Shape:SolidMolecular weight:244.37Coronarin D
CAS:Coronarin D has antifungal properties, with 2 mg/mL MIC & 4 mg/mL MFC against C. albicans, inhibits NF-kappaB, and enhances antibiotic effects.Formula:C20H30O3Purity:98%Color and Shape:SolidMolecular weight:318.457Tapotoclax
CAS:Tapotoclax (AMG-176) is an orally active MCL1 inhibitor for the study of myeloid leukemia.Formula:C33H41ClN2O5SPurity:98.8%Color and Shape:SolidMolecular weight:613.21Liriodenine
CAS:Liriodenine: Topoisomerase II inhibitor, antitumor, antibacterial, antifungal, prevents arrhythmias, and may block M3 receptors.Formula:C17H9NO3Purity:98%Color and Shape:SolidMolecular weight:275.26WEHI-9625
CAS:WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).Formula:C34H27NO5S2Purity:98%Color and Shape:SolidMolecular weight:593.71(S)-Purvalanol B
CAS:(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .Formula:C20H25ClN6O3Purity:98%Color and Shape:SolidMolecular weight:432.9Altholactone
CAS:Altholactone, a potential antimicrobial for ciprofloxacin-resistant S. aureus/E. faecalis, also induces cancer cell apoptosis.Formula:C13H12O4Purity:98%Color and Shape:SolidMolecular weight:232.23WEHI-539 hydrochloride
CAS:WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Formula:C31H30ClN5O3S2Purity:98%Color and Shape:SolidMolecular weight:620.18Serratenediol
CAS:Serratenediol inhibits EBV-EA stronger than oleanolic acid, boosts osteoblast growth, and suppresses HL-60 cells by modulating Bax/Bcl-xL.Formula:C30H50O2Purity:98%Color and Shape:SolidMolecular weight:442.72Myricanone
CAS:Myricanone exhibits antioxidant, anticancer, apoptosis-inducing, and anti-androgenic properties with enzyme inhibition.Formula:C21H24O5Purity:98%Color and Shape:SolidMolecular weight:356.41Pyridoclax
CAS:Pyridoclax is an inhibitor of potential Mcl-1.Formula:C29H22N4Purity:98%Color and Shape:SolidMolecular weight:426.51Mcl1-IN-11
CAS:Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.Formula:C38H41N3O5S2Purity:98%Color and Shape:SolidMolecular weight:683.88Cimidahurinine
CAS:Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects againstFormula:C14H20O8Purity:98%Color and Shape:SolidMolecular weight:316.3Mcl1-IN-12
CAS:Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.Formula:C45H46N4O6S2Purity:98%Color and Shape:SolidMolecular weight:803BCL6-IN-7
CAS:BCL6-IN-7 (BCL6 inhibitor-7) is a BCL6 corepressor-interaction inhibitor with potential antitumor activity, used in lymphoma research.Formula:C18H15ClN6OPurity:99.03%Color and Shape:SolidMolecular weight:366.82',3'-Dehydrosalannol
CAS:2',3'-Dehydrosalannol deters Spodptera litura and inhibits TNBC cell growth by blocking cathepsin signals.Formula:C32H42O8Purity:98%Color and Shape:SolidMolecular weight:554.68Mcl1-IN-9
CAS:Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.Formula:C37H39ClN4O4Purity:98%Color and Shape:SolidMolecular weight:639.18MCL-1/BCL-2-IN-1
CAS:MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].Formula:C31H27BrN2O3SPurity:98%Color and Shape:SolidMolecular weight:587.53Myricanol
CAS:Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.Formula:C21H26O5Purity:98%Color and Shape:SolidMolecular weight:358.434Bax activator-1
CAS:Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].Formula:C29H36N4O3Color and Shape:SolidMolecular weight:488.62Scutebarbatine A
CAS:Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions ofFormula:C32H34N2O7Purity:98%Color and Shape:SolidMolecular weight:558.62Safflor Yellow A
CAS:Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.Formula:C27H30O15Purity:98%Color and Shape:SolidMolecular weight:594.52Mcl-1 inhibitor 3
CAS:Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activateFormula:C40H52ClF2N5O7SPurity:98%Color and Shape:SolidMolecular weight:820.39BM 957
CAS:BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).Formula:C52H56ClF3N6O7S3Purity:98%Color and Shape:SolidMolecular weight:1065.68
