Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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2'-O-(2-Azidoethyl)adenosine
CAS:2'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity.Formula:C12H16N8O4Purity:95%Color and Shape:SolidMolecular weight:336.31N-desmethyl Netupitant
CAS:N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.Formula:C29H30F6N4OPurity:98%Color and Shape:SolidMolecular weight:564.57PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Formula:C19H15F3N4O2Color and Shape:SolidMolecular weight:388.34NSC23005
CAS:NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Formula:C13H17NO4SPurity:99.71%Color and Shape:SolidMolecular weight:283.34WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Formula:C28H31N7O2Purity:98.33%Color and Shape:SolidMolecular weight:497.59Ref: TM-T8916
1mg70.00€5mg156.00€10mg239.00€25mg419.00€50mg562.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)170.00€A-286982
CAS:A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Formula:C24H27N3O4SPurity:97.81%Color and Shape:SolidMolecular weight:453.55Ref: TM-T21781
1mg35.00€2mg50.00€5mg74.00€10mg107.00€25mg210.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)81.00€CDK2-IN-19
CDK2-IN-19 (Compound 32) is a selective, orally active inhibitor of CDK2 (K i: 0.18 nM) that exhibits anticancer activity in mice with OVCAR3 tumors [1].Formula:C20H21FN6O4SPurity:98%Color and Shape:SolidMolecular weight:460.48CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Formula:C28H28N6O4Purity:98.35% - 98.65%Color and Shape:SolidMolecular weight:512.56Ref: TM-T4482
1mg52.00€5mg111.00€10mg180.00€25mg359.00€50mg540.00€100mg775.00€500mg1,596.00€1mL*10mM (DMSO)127.00€Rhosin
CAS:Rhosin is a specific inhibitor of RhoA GTPases (Kd: ~0.4 uM), blocking RhoA-GEF interaction, not affecting Cdc42/Rac1/LARG, and induces apoptosis.Formula:C20H18N6OPurity:98%Color and Shape:SolidMolecular weight:358.43MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Formula:C17H21N5Purity:99.97%Color and Shape:White SolidMolecular weight:295.38Ref: TM-T21678
5mg52.00€10mg96.00€25mg170.00€50mg269.00€100mg394.00€500mgTo inquire1mL*10mM (DMSO)58.00€2-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Formula:C4H3ClN2Purity:98.98% - 99.81%Color and Shape:Clear Colorless To Yellowish LiquidMolecular weight:114.53Trilaciclib
CAS:Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).Formula:C24H30N8OPurity:98%Color and Shape:SolidMolecular weight:446.55NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Formula:C16H19ClN6OPurity:98% - 99.36%Color and Shape:SolidMolecular weight:346.81Ref: TM-T2028
1mg74.00€2mg97.00€5mg158.00€10mg269.00€25mg515.00€50mg743.00€100mg1,035.00€500mg2,080.00€1mL*10mM (DMSO)158.00€5-Bromouridine
CAS:5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.Formula:C9H11BrN2O6Purity:99.89%Color and Shape:White PowderMolecular weight:323.1CDK9-IN-15
CAS:CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Formula:C16H11N3OSPurity:97.24%Color and Shape:SolidMolecular weight:293.34Ref: TM-T60619
2mg42.00€5mg64.00€10mg97.00€25mg183.00€50mg273.00€100mg393.00€200mg550.00€1mL*10mM (DMSO)62.00€Fosifloxuridine nafalbenamide
CAS:Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.Formula:C29H29FN3O9PPurity:95.87%Color and Shape:SolidMolecular weight:613.53Ref: TM-T33762
1mg88.00€5mg160.00€10mg216.00€25mg393.00€50mg550.00€100mg753.00€500mg1,549.00€1mL*10mM (DMSO)210.00€Retifanlimab
CAS:Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.Purity:95% - 95%Color and Shape:Liquid2'-O-Methyl-2-thiouridine
CAS:2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.Formula:C10H14N2O5SPurity:99.89%Color and Shape:SolidMolecular weight:274.292'-O-Methylinosine
CAS:2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.Formula:C11H14N4O5Purity:99.88%Color and Shape:SolidMolecular weight:282.25B I09
CAS:B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Formula:C16H17NO5Purity:99.23%Color and Shape:SolidMolecular weight:303.31Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Formula:C93H134N22O25Purity:99.92%Color and Shape:SolidMolecular weight:1960.19ML-60218
CAS:ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.Formula:C19H15Cl2N3O2S2Purity:98.1%Color and Shape:SolidMolecular weight:452.38Ref: TM-T40661
1mg56.00€5mg119.00€10mg187.00€25mg411.00€50mg638.00€100mg908.00€200mg1,225.00€1mL*10mM (DMSO)131.00€Filanesib
CAS:Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.Formula:C20H22F2N4O2SPurity:98.06%Color and Shape:SolidMolecular weight:420.48Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.Formula:C18H22BrN5O3Purity:98.86% - 99.63%Color and Shape:SolidMolecular weight:436.3BMS-1166
CAS:BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.Formula:C36H33ClN2O7Purity:99.22%Color and Shape:SolidMolecular weight:641.11Ref: TM-T5697
1mg74.00€5mg155.00€10mg225.00€25mg429.00€50mg635.00€100mg944.00€200mg1,264.00€1mL*10mM (DMSO)208.00€6-AZATHYMINE
CAS:6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.Formula:C4H5N3O2Purity:99.47%Color and Shape:SolidMolecular weight:127.1CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formula:C20H23N9OPurity:98.78%Color and Shape:SolidMolecular weight:405.46Ref: TM-T10791
1mg185.00€2mg279.00€5mg424.00€10mg627.00€25mg938.00€50mg1,311.00€100mg1,795.00€1mL*10mM (DMSO)470.00€Y16 acetate(429653-73-6 free base)
Y16 acetate(429653-73-6 free base) is a G-protein-coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoAFormula:C51H74N14O13Purity:98%Color and Shape:SolidMolecular weight:1091.24Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formula:C12H15N5O5Purity:98.11%Color and Shape:SolidMolecular weight:309.28Ref: TM-T9605
1mg126.00€5mg274.00€10mg416.00€25mg677.00€50mg944.00€100mg1,264.00€1mL*10mM (DMSO)360.00€Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Formula:C9H13N3O4SPurity:98%Color and Shape:SolidMolecular weight:259.28CP-07
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formationFormula:C45H48N6O8Purity:98%Color and Shape:SolidMolecular weight:800.95,6-Dihydro-5-methyluracil
CAS:5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.Formula:C5H8N2O2Purity:98.53%Color and Shape:SolidMolecular weight:128.13Dostarlimab
CAS:Dostarlimab (TSR-042) is an immune checkpoint inhibitor targeting PD-1, blocking its interaction with its ligands PD-L1 and PD-L2.Purity:>95%Color and Shape:LiquidGW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Formula:C20H11Cl2NO4Purity:98.23%Color and Shape:SolidMolecular weight:400.21Ref: TM-T9207L
1mg131.00€5mg286.00€10mg430.00€25mg647.00€50mg969.00€100mg1,301.00€1mL*10mM (DMSO)283.00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formula:C22H18N4Purity:98.07% - 98.74%Color and Shape:SolidMolecular weight:338.41Ref: TM-T16021
1mg37.00€2mg52.00€5mg79.00€10mg111.00€25mg208.00€50mg376.00€100mg567.00€1mL*10mM (DMSO)87.00€RP-6685
CAS:RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.Formula:C22H14F7N5OPurity:98.34%Color and Shape:SoildMolecular weight:497.37Ref: TM-T60187
1mg88.00€5mg160.00€10mg230.00€25mg378.00€50mg538.00€100mg755.00€1mL*10mM (DMSO)170.00€dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H53Cl2FN8O12Purity:99.44%Color and Shape:SolidMolecular weight:1071.93CDK9-IN-35
CDK9-IN-35 (compound 10j) acts as an inhibitor of CDK9/CyclinT1, exhibiting an IC50 of 10.2 nM. It also shows an IC50 of 20 nM against the HCT-116 cell line.Formula:C26H24ClFN4O4SColor and Shape:SolidMolecular weight:543.01Anticancer agent 73
CAS:Anticancer agent 73 inhibits TRBP, disrupting TRBP-Dicer, and hinders HCC growth and spread by altering HCC miRNA and protein expression.Formula:C14H15NO4Purity:99.19%Color and Shape:SolidMolecular weight:261.27Rifaximin
CAS:Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Formula:C43H51N3O11Purity:98.05% - 99.40%Color and Shape:Red-Orange Crystalline PowderMolecular weight:785.88Men 10376
CAS:Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.Formula:C57H68N12O10Purity:98%Color and Shape:SolidMolecular weight:1081.22Nivolumab
CAS:Nivolumab is a monoclonal antibody, a humanized IgG4 antibody to PD-1. Nivolumab has antitumor activity. Cost-effective and quality-assured.Purity:98% - 98%Color and Shape:LiquidMolecular weight:146 kDa2',3'-Bis-(O-t-butyldimethylsilyl)uridine
CAS:2',3'-Bis-(O-t-butyldimethylsilyl)uridine is a nucleoside derivative protect the NH2/OH groups of nucleosides.inhibitory on viral replication,AIDS and herpes.Formula:C21H40N2O6Si2Purity:99.88%Color and Shape:SolidMolecular weight:472.72Ref: TM-TNU1182
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€Vitamin D2
CAS:Ergocaliferol (Vitamin D2), derived from ergosterol by UV, inhibits bladder tumor promotion and leukemia, and blocks DNA Polymerase.Formula:C28H44OPurity:98.73% - ≥98%Color and Shape:Prisms From Acetone 1998)Molecular weight:396.65Aurora Kinases-IN-4
CAS:Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formula:C26H28N8OPurity:98%Color and Shape:SolidMolecular weight:468.55P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Formula:C53H81N13O11Purity:99.61%Color and Shape:SolidMolecular weight:1076.29Beaucage reagent
CAS:Beaucage reagent, which is found to be effective in causing DNA cleavage.Formula:C7H4O3S2Purity:95.19%Color and Shape:White To Off-White PowderMolecular weight:200.23Abemaciclib metabolite M20
CAS:Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂,可用于癌症治疗的相关研究。Formula:C27H32F2N8OPurity:98.32% - 99.29%Color and Shape:SolidMolecular weight:522.59CDK2/Bcl2-IN-1
CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells.Formula:C35H56O10SPurity:98%Color and Shape:SolidMolecular weight:668.88RAD51-IN-1
CAS:Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.Formula:C22H16ClN3OPurity:99.95%Color and Shape:SolidMolecular weight:373.833-Deazauridine
CAS:3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Formula:C10H13NO6Purity:98.55%Color and Shape:SolidMolecular weight:243.21Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formula:C31H35ClN8O2Purity:98.02% - 98.02%Color and Shape:SolidMolecular weight:587.112-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Formula:C12H24ClNO4Color and Shape:SolidMolecular weight:281.78GS-443902
CAS:Remdesivir triphosphate (GS-443902) inhibits RSV/HCV RdRp with IC50s: 1.1/5 µM.Formula:C12H16N5O13P3Purity:98%Color and Shape:SolidMolecular weight:531.2MU1409
CAS:MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.Formula:C20H14BrN3O3SColor and Shape:SolidMolecular weight:456.312Senexin A
CAS:Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Formula:C17H14N4Purity:99.74%Color and Shape:SolidMolecular weight:274.32Ref: TM-T5673
1mg37.00€5mg77.00€10mg99.00€25mg187.00€50mg340.00€100mg485.00€200mg657.00€1mL*10mM (DMSO)74.00€Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formula:C27H27F2N7O5S2Purity:98.71%Color and Shape:SolidMolecular weight:631.67PD-1/PD-L1-IN-9
CAS:PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.Formula:C22H24N2O2Purity:99.37%Color and Shape:SolidMolecular weight:348.44Ref: TM-T9651
1mg60.00€2mg89.00€5mg134.00€10mg188.00€25mg314.00€50mg429.00€100mg565.00€500mg1,121.00€1mL*10mM (DMSO)148.00€T7 RNA polymerase
CAS:T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcriptionPurity:98%Color and Shape:SolidPD-L1-IN-7
CAS:PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Formula:C46H50N6O7Color and Shape:SolidMolecular weight:798.93BET/Aurora kinase-IN-1
CAS:BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Formula:C25H30FN7OColor and Shape:SolidMolecular weight:463.555-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formula:C8H13N3SPurity:99.03%Color and Shape:SolidMolecular weight:183.27PD-1/PD-L1 inhibitory peptide C8
PD-1/PD-L1 inhibitory peptide C8 disrupts the PD-1/PD-L1 interaction, leading to the activation of CD8+ and CD4+ T cells and an increase in IFN-γ secretion. In mouse models, PD-1/PD-L1 inhibitory peptide C8 has demonstrated antitumor activity.Formula:C51H72N14O14S2Color and Shape:SolidMolecular weight:1169.33MRK-952
MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.Formula:C20H20ClF3N6Color and Shape:SolidMolecular weight:436.861CKK-E12
CAS:CKK-E12 is an ionizable lipid for RNA delivery via lipid nanoparticles, with high liver cell selectivity in vivo.Formula:C60H120N4O6Purity:98.328%Color and Shape:SolidMolecular weight:993.62AZA197
CAS:AZA197 (AZA-197) is a selective Cdc42 inhibitor.Formula:C24H36N6Purity:100%Color and Shape:SolidMolecular weight:408.58Lobucavir
CAS:Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).Formula:C11H15N5O3Color and Shape:SolidMolecular weight:265.27CCG-257081
CAS:CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.Formula:C24H19ClF3N3O2Purity:98% - 99.92%Color and Shape:SolidMolecular weight:473.87TCS7010
CAS:TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Formula:C31H31ClFN7O2Purity:98.49% - 99.62%Color and Shape:SolidMolecular weight:588.07Risdiplam
CAS:Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Formula:C22H23N7OPurity:98.68% - 99.43%Color and Shape:SolidMolecular weight:401.46GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formula:C27H36FN3O4Color and Shape:SolidMolecular weight:485.59(S)-DI-87
CAS:(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor,reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.Formula:C23H30N6O3S2Purity:99.42%Color and Shape:SoildMolecular weight:502.65Ref: TM-T39550L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€KWR095
CAS:KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.Formula:C33H31ClF3N9O4Color and Shape:SolidMolecular weight:710.105Thymectacin
CAS:Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.Formula:C21H25BrN3O9PPurity:98.41% - 99.82%Color and Shape:SolidMolecular weight:574.32Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Formula:C22H19ClF3NO5Purity:99.89%Color and Shape:SolidMolecular weight:469.84CDK4/6-IN-6
CAS:CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.Formula:C22H27ClFN5O3Purity:95.63%Color and Shape:SolidMolecular weight:463.93DNA polymerase-IN-3
CAS:DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFormula:C13H12O4Purity:98%Color and Shape:SolidMolecular weight:232.23ARB-272572 hydrochloride
CAS:ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formula:C32H36N6O4·xClHPurity:99%Color and Shape:SoildMolecular weight:568.68(Free base）5-OHdU
CAS:5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.Formula:C9H12N2O6Purity:98.32%Color and Shape:SolidMolecular weight:244.2Ref: TM-T19152
1mg47.00€2mg60.00€5mg89.00€10mg131.00€25mg212.00€50mg316.00€100mg474.00€1mL*10mM (DMSO)90.00€Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formula:C24H29N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:447.53Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H10ClFN5Na3O9P2Color and Shape:SolidMolecular weight:529.58BRD9876
CAS:BRD9876 is a selective inhibitor of MM1S growth.Formula:C16H14N2Purity:97.81%Color and Shape:SolidMolecular weight:234.3Bractoppin
CAS:Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibitsFormula:C25H23FN4OPurity:98.38%Color and Shape:SolidMolecular weight:414.47Ref: TM-T8873
1mg49.00€5mg104.00€10mg166.00€25mg325.00€50mg490.00€100mg737.00€500mg1,483.00€1mL*10mM (DMSO)115.00€Werner syndrome RecQ helicase-IN-4
CAS:Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Formula:C32H33F3N8O5Purity:98.27%Color and Shape:SolidMolecular weight:666.65YKL-5-124
CAS:YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFormula:C28H33N7O3Purity:99.5%Color and Shape:SolidMolecular weight:515.61Ref: TM-T22461
1mg96.00€2mg135.00€5mg188.00€10mg341.00€25mg548.00€50mg782.00€100mg1,035.00€1mL*10mM (DMSO)225.00€SNX7
CAS:SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formula:C15H14N2OPurity:99.05%Color and Shape:SolidMolecular weight:238.28MIRA-1
CAS:MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activityFormula:C8H9NO4Purity:99.38%Color and Shape:SolidMolecular weight:183.16CDK4/6/1 Inhibitor
CAS:CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Formula:C28H30F2N6Purity:97.99% - 99.26%Color and Shape:SolidMolecular weight:488.57TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Formula:C27H18F4N4O3SPurity:98% - 98.92%Color and Shape:SolidMolecular weight:554.52bio-THZ1
CAS:bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).Formula:C52H65ClN12O8SPurity:98%Color and Shape:SolidMolecular weight:1053.67Roxifiban acetate
CAS:Roxifiban acetate(DMP 754 acetate) is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormula:C23H33N5O8Purity:99.33% - 99.56%Color and Shape:SolidMolecular weight:507.54CDK2-IN-31
CAS:CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Formula:C37H52N6O5Color and Shape:SolidMolecular weight:660.85Levomefolate calcium
CAS:Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Formula:C20H23CaN7O6Purity:97.35% - 98%Color and Shape:Off-White To Pale Yellow SolidMolecular weight:497.52Deoxycytidine triphosphate trisodium salt
CAS:Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.Formula:C9H13N3Na3O13P3Purity:99.80%Color and Shape:SolidMolecular weight:533.1ZYN57939
CAS:ZYN57939 (MTR-106), an RNA polymerase I inhibitor, treats related diseases with a 0.855 μM IC50 against HT-29 cells.Formula:C28H27N7O2SPurity:99.68%Color and Shape:SolidMolecular weight:525.62Trifluridine/tipiracil hydrochloride mixture
CAS:Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in aFormula:C29H34Cl2F6N8O12Purity:99.37% - ≥98%Color and Shape:SolidMolecular weight:871.53Ref: TM-T3658
2mg39.00€5mg57.00€10mg87.00€25mg157.00€50mg250.00€100mg378.00€200mg568.00€500mg889.00€1mL*10mM (DMSO)78.00€PD173952
CAS:PD173952 is a Src kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.Formula:C24H21Cl2N5O2Purity:99.5%Color and Shape:SolidMolecular weight:482.36BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formula:C17H12Cl2F2N4OSPurity:99.19% - 99.31%Color and Shape:SolidMolecular weight:429.27Avotaciclib
CAS:Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastaticFormula:C13H11N7OPurity:97.98%Color and Shape:SolidMolecular weight:281.27Ac-rC Phosphoramidite
CAS:Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.Formula:C47H64N5O9PSiPurity:99.49%Color and Shape:SolidMolecular weight:902.1Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFormula:C31H32N8O5Purity:98%Color and Shape:SolidMolecular weight:596.64SB273005
CAS:SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Formula:C22H24F3N3O4Purity:99.58%Color and Shape:SolidMolecular weight:451.44Ribociclib hydrochloride
CAS:Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formula:C23H31ClN8OPurity:98%Color and Shape:SolidMolecular weight:471PD-1/PD-L1-IN-33
CAS:PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formula:C26H27N5OPurity:98%Color and Shape:SolidMolecular weight:425.53KIF18A-IN-14
CAS:KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.Formula:C26H32F3N5O6SColor and Shape:SolidMolecular weight:599.62MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formula:C22H21ClFN3O3SPurity:100%Color and Shape:SolidMolecular weight:461.94Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Purity:> 95%Color and Shape:LiquidMolecular weight:145.36 kDa8-Azahypoxanthine
CAS:8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.Formula:C4H3N5OPurity:≥98%Color and Shape:Light Yellow To Light Beige Fine CrystallineMolecular weight:137.1Ref: TM-T20102
5mg48.00€10mg66.00€25mg104.00€50mg154.00€100mg216.00€200mg324.00€1mL*10mM (DMSO)48.00€Datelliptium chloride hydrochloride
CAS:Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.Formula:C23H29Cl2N3OPurity:99.46%Color and Shape:SolidMolecular weight:434.4ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formula:C29H31N5O4Purity:98.53% - 99.11%Color and Shape:Pale Yellow SolidMolecular weight:513.59MBM-17
CAS:MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM).Formula:C28H28N6O2Purity:98%Color and Shape:SolidMolecular weight:480.56Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.Formula:C25H30N6O2Purity:98.32%Color and Shape:SolidMolecular weight:446.54BVDV-IN-1
CAS:BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.Formula:C20H22N4OPurity:98.43%Color and Shape:SolidMolecular weight:334.41Ref: TM-T9103
1mg40.00€5mg90.00€10mg131.00€25mg255.00€50mg375.00€100mg535.00€200mg725.00€1mL*10mM (DMSO)90.00€KSI-3716
CAS:KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.Formula:C17H11BrCl2N2O2Purity:98.94%Color and Shape:SolidMolecular weight:426.09IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formula:C23H21Cl2NO5Purity:98%Color and Shape:SolidMolecular weight:462.32Rabacfosadine
CAS:Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma.Formula:C21H35N8O6PPurity:98.75% - 99.43%Color and Shape:SolidMolecular weight:526.53CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Formula:C30H32ClN7O2Purity:97.17% - 99.86%Color and Shape:SolidMolecular weight:558.07Ref: TM-T4293
1mg63.00€2mg90.00€5mg111.00€10mg153.00€25mg329.00€50mg472.00€100mg687.00€500mg1,415.00€1mL*10mM (DMSO)137.00€IRE1α kinase-IN-8
CAS:IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Formula:C23H22N2O5Purity:98%Color and Shape:SolidMolecular weight:406.43SY-5609
CAS:SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formula:C23H26F3N6OPPurity:99.32% - 99.34%Color and Shape:SolidMolecular weight:490.46Ref: TM-T36038
1mg139.00€2mg200.00€5mg343.00€10mg553.00€25mgTo inquire50mgTo inquire1mL*10mM (DMSO)399.00€BRD4 Inhibitor-40
CAS:BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.Formula:C27H32N8OColor and Shape:SolidMolecular weight:484.596PD-1/PD-L1-IN-26
CAS:PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.Formula:C43H52N4O8Purity:98%Color and Shape:SolidMolecular weight:752.89Briciclib
CAS:Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.Formula:C19H23O10PSPurity:98% - 99.84%Color and Shape:SolidMolecular weight:474.42Ref: TM-T3207
1mg47.00€2mg57.00€5mg88.00€10mg126.00€25mg250.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)87.00€8-Chloroinosine
CAS:8-Chloroinosine is a purine nucleoside analog and a metabolite of the anticancer compound 8-chloro-adenosine.Formula:C10H11ClN4O5Purity:99.37% - 99.56%Color and Shape:SolidMolecular weight:302.67H3B-968
CAS:H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFormula:C22H18F6N4O4SPurity:98%Color and Shape:SolidMolecular weight:548.46CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formula:C19H17N3O4Purity:99.98%Color and Shape:SolidMolecular weight:351.36CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Formula:C18H19ClFN5OSPurity:100%Color and Shape:SolidMolecular weight:407.891-Methylinosine
CAS:1-Methylinosine (N1-Methylinosine) is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA and has a role as a metabolite.Formula:C11H14N4O5Purity:98.13%Color and Shape:SolidMolecular weight:282.25CDK9-IN-27
CDK9-IN-27 (Compound 6a), a CDK9 inhibitor with an IC50 of 0.424 μM, induces apoptosis and S-phase cell cycle arrest.Formula:C23H18ClN5O3Purity:98%Color and Shape:SolidMolecular weight:447.87CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formula:C21H17ClF6N2O2Purity:99.58%Color and Shape:SolidMolecular weight:478.82Ref: TM-T22062
5mg38.00€10mg57.00€25mg114.00€50mg188.00€100mg303.00€200mg449.00€1mL*10mM (DMSO)43.00€Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formula:C27H35F2N7O3Purity:100% - 98%Color and Shape:SolidMolecular weight:543.61CDK7-IN-31
CAS:CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Formula:C27H32F5N6O2PColor and Shape:SolidMolecular weight:598.55SR18662
SR18662, improved ML264 derivative, inhibits KLF5 at 4.4 nM IC50; curbs colorectal cancer cell growth and triggers apoptosis.Formula:C16H19Cl2N3O4SPurity:98.97% - 99.2%Color and Shape:SolidMolecular weight:420.31Ref: TM-T22429
1mg48.00€5mg96.00€10mg160.00€25mg311.00€50mg502.00€100mg718.00€200mg938.00€500mg1,454.00€1mL*10mM (DMSO)105.00€InhA-IN-2
CAS:N-[3-(Aminomethyl)phenyl]-5-chloro-3-methyl-benzo[b]thiophene-2-sulfonamide inhibits InhA without KatG activation.Formula:C16H15ClN2O2S2Purity:98.4%Color and Shape:SolidMolecular weight:366.89Ref: TM-T9734
1mg87.00€5mg192.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)197.00€Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32DDRI-18
CAS:DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.Formula:C26H20N6Purity:98%Color and Shape:SolidMolecular weight:416.48N-deacetylated BMS-202
CAS:N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.Formula:C23H27N3O2Purity:98.13% - 98.13%Color and Shape:SolidMolecular weight:377.48ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurity:99.69%Color and Shape:SolidMolecular weight:232.24NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formula:C24H30N6OColor and Shape:SolidMolecular weight:418.535SWS1
CAS:SWS1, a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM), displays anticancer activity by augmenting tumor-infiltrating lymphocytes and demonstrating antiFormula:C47H53ClN6O5SPurity:98%Color and Shape:SolidMolecular weight:849.48CCT251455
CAS:CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.Formula:C26H26ClN7O2Purity:99.1% - 99.1%Color and Shape:SolidMolecular weight:503.98P162-0948
CAS:P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.Formula:C20H15FN4O2Color and Shape:SolidMolecular weight:362.357Silver sulfadiazine
CAS:Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Formula:C10H9AgN4O2SPurity:99.04% - 99.58%Color and Shape:SolidMolecular weight:357.14Vedolizumab
CAS:Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.Purity:SDS-PAGE:98.4%;SEC-HPLC:99.1%Color and Shape:LiquidMolecular weight:146.80 kDaMK-8745
CAS:MK-8745 is a potent and selective Aurora A inhibitor.Formula:C20H19ClFN5OSPurity:98.94% - 99.31%Color and Shape:SolidMolecular weight:431.913-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purity:98%Color and Shape:SolidMolecular weight:212.2Pyridostatin Trihydrochloride
CAS:Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Formula:C31H35Cl3N8O5Purity:99.69%Color and Shape:SolidMolecular weight:706.02Enocitabine
CAS:Enocitabine is a nucleoside analog.Formula:C31H55N3O6Purity:98.02%Color and Shape:SolidMolecular weight:565.78AZD4573
CAS:AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formula:C22H28ClN5O2Purity:99.23% - 99.63%Color and Shape:SolidMolecular weight:429.94CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formula:C23H21ClN2O3Purity:98.82% - 99.35%Color and Shape:SolidMolecular weight:408.88Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formula:C26H21N3O3Purity:97.45%Color and Shape:SolidMolecular weight:423.46Ref: TM-T11155
1mg92.00€5mg205.00€10mg305.00€25mg495.00€50mg677.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)227.00€NU6102
CAS:NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.Formula:C18H22N6O3SPurity:99.76%Color and Shape:SolidMolecular weight:402.47CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formula:C18H19ClFN3O2Purity:99.52%Color and Shape:SolidMolecular weight:363.81Ref: TM-TQ0078
1mg40.00€2mg54.00€5mg92.00€10mg145.00€25mg271.00€50mg398.00€100mg562.00€500mg1,121.00€1mL*10mM (DMSO)97.00€PTC-209 hydrobromide
CAS:PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results inFormula:C17H13Br2N5OS·HBrPurity:98%Color and Shape:SolidMolecular weight:576.1SHR5428
SHR5428 is an orally active, selective, noncovalent inhibitor of CDK7, displaying potent enzymatic inhibition (IC50 = 2.3 nM) and effectively suppressingPurity:98%Color and Shape:Odour Solid5-Aminouridine
CAS:5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA.Formula:C9H13N3O6Purity:100%Color and Shape:SolidMolecular weight:259.22LTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Formula:C53H59Cl2N3O7S2Color and Shape:SolidMolecular weight:985.09Cytembena
CAS:Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.Formula:C11H8BrNaO4Purity:99.53%Color and Shape:White PowderMolecular weight:307.07CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formula:C23H28F2N8OPurity:99.85%Color and Shape:SolidMolecular weight:470.52Ref: TM-T14990
1mg130.00€5mg311.00€10mg512.00€25mg1,074.00€50mg1,795.00€100mg2,375.00€1mL*10mM (DMSO)344.00€PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formula:C20H12N2O3Purity:98.02%Color and Shape:SolidMolecular weight:328.32AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Formula:C28H21N7OSPurity:98.35% - 98.9%Color and Shape:SolidMolecular weight:503.58Ref: TM-T6380
1mg52.00€5mg97.00€10mg166.00€25mg303.00€50mg467.00€100mg682.00€500mg1,415.00€1mL*10mM (DMSO)105.00€GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formula:C27H28F3N5O2SPurity:98.85% - 99.5%Color and Shape:SolidMolecular weight:543.6Ref: TM-T6282
1mg37.00€2mg52.00€5mg74.00€10mg124.00€25mg207.00€50mg374.00€100mg557.00€200mg797.00€500mg1,216.00€β-catenin-IN-8
CAS:β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Formula:C15H12ClN3O2SColor and Shape:SolidMolecular weight:333.79Socazolimab
CAS:Socazolimab (ZKAB001) is a monoclonal antibody targeting PD-L1 with antitumor activity, used in studies of recurrent or metastatic cervical cancer.Purity:95%Color and Shape:LiquidPS423
CAS:PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Formula:C25H23F3O9Purity:98.81% - 99.26%Color and Shape:SolidMolecular weight:524.442'-Deoxy-2'-fluoroarabinoadenosine
CAS:2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue with extensive anti-tumor activity and can be used for the study of tumor diseases.Formula:C10H12FN5O3Purity:99.44%Color and Shape:SolidMolecular weight:269.23PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Formula:C22H25ClN2O4Color and Shape:SolidMolecular weight:416.90Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Formula:C24H32Cl2N8OPurity:98.61% - 99.69%Color and Shape:SolidMolecular weight:519.47Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Formula:C21H31N7OPurity:99.75%Color and Shape:SolidMolecular weight:397.52Ref: TM-TQ0053
1mg48.00€5mg101.00€10mg178.00€25mg304.00€50mg437.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)111.00€KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formula:C28H38N4O5S2Purity:98.45%Color and Shape:SolidMolecular weight:574.76Ro5-3335
CAS:Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.Formula:C13H10ClN3OPurity:99.42% - 99.50%Color and Shape:SolidMolecular weight:259.69(S)-PF-06873600
CAS:(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Formula:C20H27F2N5O4SPurity:98.55%Color and Shape:SolidMolecular weight:471.52Orotic acid zinc
CAS:Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.Formula:C10H6N4O8ZnPurity:99.13%Color and Shape:SolidMolecular weight:188.79VVD-214
CAS:VVD-214 (RO7589831) is a WRN deconjugation enzyme lethal-mutagenic inhibitor that can be used to study proliferative diseases.Formula:C20H21F2N3O4SPurity:99.24%Color and Shape:SoildMolecular weight:437.46N-Nitrosonornicotine
CAS:N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.Formula:C9H11N3OColor and Shape:SolidMolecular weight:177.2ARQ 621
CAS:ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Formula:C28H24Cl2FN5O2Purity:98.38%Color and Shape:SolidMolecular weight:552.43Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Formula:C29H24Cl2N2O7SPurity:99.39% - 99.66%Color and Shape:SolidMolecular weight:615.48Cdc7-IN-7c
CAS:Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Formula:C15H17N5OSPurity:99.31% - 99.77%Color and Shape:SolidMolecular weight:315.39Ref: TM-T23867
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)633.00€CDK12-IN-2
CAS:CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.Formula:C32H32N6O2Purity:99.54%Color and Shape:SolidMolecular weight:532.64Ref: TM-T39752
1mg92.00€5mg216.00€10mg376.00€25mg620.00€50mg889.00€100mg1,198.00€1mL*10mM (DMSO)255.00€Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formula:C29H42F3N9O9Purity:98.99% - 99.54%Color and Shape:SolidMolecular weight:717.69TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formula:C24H26N2O3SPurity:98.23%Color and Shape:SolidMolecular weight:422.54Peresolimab
CAS:Peresolimab, a humanized IgG1-κ antibody, targets PD-1 and may activate physiological immune inhibitory pathways, thereby restoring immune homeostasis [1] [2].Purity:98%Color and Shape:Liquid10-Formyl-5,8-dideazafolic acid
CAS:10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.Formula:C22H21N5O7Purity:96.04%Color and Shape:SolidMolecular weight:467.43CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Formula:C26H32BrN5O6Purity:98.05% - 98.5%Color and Shape:SolidMolecular weight:590.47Ref: TM-TQ0250
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg221.00€50mg369.00€100mg550.00€1mL*10mM (DMSO)96.00€2',5-Difluoro-2'-deoxy-1-arabinosyluracil
CAS:2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepilepticFormula:C9H10F2N2O5Purity:99.94%Color and Shape:SolidMolecular weight:264.18FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formula:C17H18FN3SPurity:98.61%Color and Shape:SolidMolecular weight:315.41KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Formula:C33H31ClF3N9O4Color and Shape:SolidMolecular weight:710.105PD-1/PD-L1-IN-31
PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral bloodFormula:C24H24ClFN2O3Purity:98%Color and Shape:SolidMolecular weight:442.915'-O-DMT-N2-ibu-dG
CAS:5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.Formula:C35H37N5O7Purity:98.71%Color and Shape:SolidMolecular weight:639.7Isoindigotin
CAS:Isoindigotin is used in the therapy of Y.Formula:C16H10N2O2Purity:97.52% - ≥95%Color and Shape:SolidMolecular weight:262.26Tislelizumab
CAS:Tislelizumab, a PD-1 receptor monoclonal antibody, reduces Fcγ interaction and T cell clearance in advanced squamous NSCLC research.Purity:95%Color and Shape:LiquidDebio-0123
CAS:Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formula:C26H28Cl2N6OPurity:99.52%Color and Shape:SolidMolecular weight:511.45Ref: TM-T9864
1mg95.00€5mg227.00€10mg359.00€25mg607.00€50mg868.00€100mg1,169.00€1mL*10mM (DMSO)255.00€BCH001
CAS:BCH001 is a specific small-molecule inhibitor of PAPD5.Formula:C20H15F3N2O5Purity:99.06%Color and Shape:SolidMolecular weight:420.34Human membrane-bound PD-L1 polypeptide
CAS:Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formula:C85H140N26O36SPurity:98%Color and Shape:SolidMolecular weight:2134.24GSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurity:99.73%Color and Shape:SolidMolecular weight:507.63Adenine hydrochloride
CAS:Adenine hydrochloride (6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.Formula:C5H5N5·HClPurity:98.86%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:171.59RS-1
CAS:RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.Formula:C20H16Br2N2O3SPurity:99.72%Color and Shape:SolidMolecular weight:524.23Ref: TM-T6972
5mg51.00€10mg79.00€25mg126.00€50mg210.00€100mg354.00€200mg517.00€500mg825.00€1mL*10mM (DMSO)59.00€TREX1-IN-4
CAS:TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.Formula:C24H19ClN6O4Color and Shape:SolidMolecular weight:490.898Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Formula:C30H32ClN7OSPurity:98%Color and Shape:SolidMolecular weight:574.14
![5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8912.webp&w=3840&q=75)
