Chk
Chk (Checkpoint Kinase) inhibitors target the Chk1 and Chk2 kinases, which are key regulators of the DNA damage response and cell cycle checkpoints. These kinases halt cell cycle progression in response to DNA damage, allowing time for repair. Inhibiting Chk kinases can prevent cell cycle arrest, forcing damaged cells to proceed through the cycle and ultimately undergo apoptosis. Chk inhibitors are particularly valuable in cancer research, where they can sensitize tumor cells to DNA-damaging agents. At CymitQuimica, we provide a variety of high-quality Chk inhibitors to support your research in DNA damage response, cell cycle regulation, and oncology.
Products of "Chk"
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CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formula:C20H24N8O2Purity:99.17%Color and Shape:SolidMolecular weight:408.46GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Formula:C16H20BrN5OPurity:≥95%Color and Shape:SolidMolecular weight:378.27CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purity:98.02%Color and Shape:SoildMolecular weight:480.75CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurity:97.06% - 99.69%Color and Shape:SolidMolecular weight:379.34Ref: TM-T7080
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg225.00€50mg369.00€100mg552.00€1mL*10mM (DMSO)92.00€VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Formula:C31H34N6O3Purity:98%Color and Shape:SolidMolecular weight:538.64Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.Formula:C18H22BrN5O3Purity:98.86% - 99.63%Color and Shape:SolidMolecular weight:436.3CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formula:C20H23N9OPurity:98.78%Color and Shape:SolidMolecular weight:405.46Ref: TM-T10791
1mg185.00€2mg279.00€5mg424.00€10mg627.00€25mg938.00€50mg1,311.00€100mg1,795.00€1mL*10mM (DMSO)470.00€CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Formula:C18H19ClFN5OSPurity:100%Color and Shape:SolidMolecular weight:407.89SB-218078
CAS:SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM).Formula:C24H15N3O3Purity:98%Color and Shape:SolidMolecular weight:393.39ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Formula:C13H8Cl2N2Purity:99.21%Color and Shape:SolidMolecular weight:263.12PHI-101
CAS:PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.Formula:C19H19FN4O2SPurity:99.40%Color and Shape:SolidMolecular weight:386.44Ref: TM-T81490
1mg173.00€5mg437.00€10mg702.00€25mg1,406.00€50mg2,262.00€100mg3,600.00€1mL*10mM (DMSO)469.00€SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Formula:C15H18BrN7Purity:96.69% - 99.6%Color and Shape:SolidMolecular weight:376.25Ref: TM-T2517
1mg52.00€2mg78.00€5mg115.00€10mg168.00€25mg283.00€50mg462.00€100mg660.00€1mL*10mM (DMSO)124.00€AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurity:98.96% - 99.19%Color and Shape:SolidMolecular weight:362.42Ref: TM-T6093
1mg38.00€2mg49.00€5mg81.00€10mg96.00€25mg177.00€50mg280.00€100mg449.00€1mL*10mM (DMSO)88.00€SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formula:C15H18BrN7Purity:99.95%Color and Shape:SolidMolecular weight:376.25Ref: TM-T3700
1mg49.00€2mg70.00€5mg96.00€10mg155.00€25mg264.00€50mg424.00€100mg627.00€1mL*10mM (DMSO)114.00€CHK1-IN-4
CAS:CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.Formula:C18H18BrN7O2Purity:98%Color and Shape:SolidMolecular weight:444.29LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purity:99.77%Color and Shape:SolidMolecular weight:381.43Ref: TM-T9252
1mg131.00€5mg286.00€10mg430.00€25mg710.00€50mg998.00€100mg1,349.00€1mL*10mM (DMSO)316.00€CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formula:C17H21BrN4OPurity:98%Color and Shape:SolidMolecular weight:377.28CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H28ClFN4O4Purity:97.13%Color and Shape:SolidMolecular weight:478.95Ref: TM-T10718L
1mg73.00€2mg96.00€5mg159.00€10mg240.00€25mg515.00€50mg852.00€100mg1,264.00€500mg2,547.00€1mL*10mM (DMSO)170.00€CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purity:98%Color and Shape:SolidMolecular weight:442.48
