Integrin
Integrin inhibitors target integrins, a family of cell surface receptors that play a crucial role in cell adhesion, migration, and signal transduction. Integrins are involved in the regulation of the cell cycle, particularly in processes such as cell division and differentiation. Inhibiting integrins can disrupt these processes, leading to cell cycle arrest and apoptosis, making these inhibitors valuable in cancer research and the study of metastasis. At CymitQuimica, we offer a wide range of high-quality integrin inhibitors to support your research in cell cycle regulation, cancer biology, and therapeutic development.
Products of "Integrin"
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E7820
CAS:E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).Formula:C17H12N4O2SPurity:98.31% - 99.11%Color and Shape:SolidMolecular weight:336.37Ref: TM-T4435
1mg35.00€2mg52.00€5mg69.00€10mg88.00€25mg144.00€50mg210.00€100mg339.00€200mg502.00€1mL*10mM (DMSO)85.00€TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formula:C24H21Cl2NO5Purity:98.98%Color and Shape:SolidMolecular weight:474.33Ref: TM-T5310
1mg52.00€5mg105.00€10mg170.00€25mg298.00€50mg430.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)111.00€LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Formula:C29H48N12O12S2Purity:100%Color and Shape:SolidMolecular weight:820.89Arginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Formula:C12H22N6O6Purity:99.11%Color and Shape:SolidMolecular weight:346.34Valategrast hydrochloride
CAS:Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Formula:C30H33Cl4N3O4Purity:98%Color and Shape:SolidMolecular weight:641.41Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFormula:C18H16O8Purity:99.50% - 99.85%Color and Shape:SolidMolecular weight:360.31Bersanlimab
CAS:Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:144.22 kDaRWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Formula:C18H17F3N4O2SPurity:99.09%Color and Shape:SolidMolecular weight:410.41Ref: TM-T12783
1mg127.00€5mg311.00€10mg472.00€25mg747.00€50mg1,017.00€100mg1,311.00€200mg1,786.00€1mL*10mM (DMSO)344.00€Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purity:95% - 95%Color and Shape:Liquidαvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Formula:C28H35F3N6O8SPurity:98%Color and Shape:SolidMolecular weight:672.67αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Formula:C25H32F2N4O3Color and Shape:SolidMolecular weight:474.54Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Formula:C28H43N9O7Purity:100%Color and Shape:SolidMolecular weight:617.7ILK-IN-2
CAS:ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.Formula:C30H30F3N5OPurity:99.30%Color and Shape:SolidMolecular weight:533.59Ref: TM-T5488
1mg48.00€5mg97.00€10mg128.00€25mg162.00€50mg192.00€100mg281.00€200mg408.00€1mL*10mM (DMSO)137.00€ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Formula:C25H36F3N9O10SPurity:98% - 99.98%Color and Shape:SolidMolecular weight:711.67PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Formula:C25H26F3N5O3Purity:99.14% - 99.75%Color and Shape:SolidMolecular weight:501.5Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Purity:95%Color and Shape:Liquidβ-glycosidase-IN-1
CAS:β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.Formula:C13H23NO5Purity:98%Color and Shape:SolidMolecular weight:273.33Orbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFormula:C19H24F3N5O6Purity:97.45% - 98.43%Color and Shape:SolidMolecular weight:475.42Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFormula:C27H27F2NO6Purity:99.16%Color and Shape:SolidMolecular weight:499.5Ref: TM-TQ0291
1mg47.00€5mg87.00€10mg140.00€25mg283.00€50mg464.00€100mg747.00€200mg1,017.00€1mL*10mM (DMSO)97.00€Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Purity:95%Color and Shape:Liquid2-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Formula:C12H24ClNO4Color and Shape:SolidMolecular weight:281.78GRGDSPK
CAS:GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.Formula:C28H49N11O11Purity:98%Color and Shape:SolidMolecular weight:715.76Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Formula:C22H32N4O4Purity:99.94%Color and Shape:SolidMolecular weight:416.51SB273005
CAS:SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Formula:C22H24F3N3O4Purity:99.58%Color and Shape:SolidMolecular weight:451.44CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formula:C19H17N3O4Purity:99.98%Color and Shape:SolidMolecular weight:351.36ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurity:99.69%Color and Shape:SolidMolecular weight:232.24Tirofiban
CAS:Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Formula:C22H36N2O5SPurity:99.87%Color and Shape:SolidMolecular weight:440.63-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purity:98%Color and Shape:SolidMolecular weight:212.2A-286982
CAS:A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Formula:C24H27N3O4SPurity:97.81%Color and Shape:SolidMolecular weight:453.55Ref: TM-T21781
1mg35.00€2mg50.00€5mg74.00€10mg107.00€25mg210.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)81.00€Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Formula:C29H24Cl2N2O7SPurity:99.39% - 99.66%Color and Shape:SolidMolecular weight:615.48CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Formula:C26H32BrN5O6Purity:98.05% - 98.5%Color and Shape:SolidMolecular weight:590.47Ref: TM-TQ0250
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg221.00€50mg369.00€100mg550.00€1mL*10mM (DMSO)96.00€Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Formula:C30H32ClN7OSPurity:98%Color and Shape:SolidMolecular weight:574.14P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Formula:C53H81N13O11Purity:99.61%Color and Shape:SolidMolecular weight:1076.29αvβ1 integrin-IN-1
CAS:αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.Formula:C26H34N6O6SPurity:100% - 99.74%Color and Shape:SolidMolecular weight:558.65Ref: TM-T13473
1mg115.00€5mg274.00€10mg432.00€25mg697.00€50mg938.00€100mg1,293.00€200mg1,738.00€1mL*10mM (DMSO)349.00€GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formula:C27H36FN3O4Color and Shape:SolidMolecular weight:485.59K34c hydrochloride
K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.Formula:C38H50ClN5O2Purity:100% - 99.95%Color and Shape:SoildMolecular weight:644.29Ref: TM-T41151L
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)887.00€Lifitegrast sodium
CAS:Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.Formula:C29H23Cl2N2NaO7SPurity:99.33%Color and Shape:SolidMolecular weight:637.46Roxifiban acetate
CAS:Roxifiban acetate(DMP 754 acetate) is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormula:C23H33N5O8Purity:99.33% - 99.56%Color and Shape:SolidMolecular weight:507.54Abituzumab
CAS:Abituzumab (DI17E6) is a humanized monoclonal antibody targeting integrin alphaV, exhibiting anti-cancer activity and can be used in prostate cancer research.Purity:>95%Color and Shape:LiquidLeukadherin-1
CAS:Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.Formula:C22H15NO4S2Purity:98% - 98.49%Color and Shape:SolidMolecular weight:421.49Vedolizumab
CAS:Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.Purity:SDS-PAGE:98.4%;SEC-HPLC:99.1%Color and Shape:LiquidMolecular weight:146.80 kDa
