DYRK
DYRK (Dual-specificity Tyrosine Phosphorylation-regulated Kinase) inhibitors are compounds that target the DYRK family of kinases, which are involved in cell cycle regulation, neuronal development, and apoptosis. DYRK kinases have dual specificity, meaning they can phosphorylate both tyrosine and serine/threonine residues. Inhibiting DYRK kinases can affect various cellular processes, including cell cycle progression and differentiation. DYRK inhibitors are important tools in research on cancer, neurodegenerative diseases, and cell signaling. At CymitQuimica, we offer a selection of high-quality DYRK inhibitors to support your research in cell cycle control, neurobiology, and therapeutic development.
Products of "DYRK"
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DYR530
CAS:DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.Formula:C23H24FN7Color and Shape:SolidMolecular weight:417.48AZ-Dyrk1B-33
CAS:AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Formula:C19H16N4Purity:99.99%Color and Shape:SolidMolecular weight:300.36Ref: TM-T14364
1mg47.00€5mg97.00€10mg156.00€25mg304.00€50mg442.00€100mg615.00€200mg832.00€1mL*10mM (DMSO)105.00€Dyrk1A-IN-11
CAS:Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.Formula:C23H23F5N8OColor and Shape:SolidMolecular weight:522.47Dyrk1A-IN-12
CAS:Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Formula:C22H16FN3O2SColor and Shape:SolidMolecular weight:405.445CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Formula:C28H30N6O2Purity:98.37%Color and Shape:SolidMolecular weight:482.58CLK1-IN-3
CAS:Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A.Formula:C24H23FN6OPurity:99.79%Color and Shape:SoildMolecular weight:430.48ID-8
CAS:ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.Formula:C16H14N2O4Purity:99.32%Color and Shape:SolidMolecular weight:298.29LDN-192960
CAS:LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).Formula:C18H20N2O2SPurity:98.01% - 99.51%Color and Shape:SolidMolecular weight:328.43Ref: TM-TQ0111
1mg78.00€5mg160.00€10mg250.00€25mg502.00€50mg730.00€100mg1,026.00€200mg1,378.00€1mL*10mM (DMSO)170.00€Harmine
CAS:Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.Formula:C13H12N2OPurity:98.29% - 99.92%Color and Shape:Off-White SolidMolecular weight:212.25GNF2133
CAS:GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.Formula:C24H30N6O2Purity:98.11%Color and Shape:SolidMolecular weight:434.53Ref: TM-T40187
1mg130.00€5mg311.00€10mg472.00€25mg787.00€50mg1,169.00€100mg1,644.00€1mL*10mM (DMSO)358.00€AZ191
CAS:AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor.Formula:C24H27N7OPurity:98.04% - 99.65%Color and Shape:SolidMolecular weight:429.52Leucettine L41
CAS:Leucettine L41 (LeucettineL41) is an inhibitor of DYRKs/CLKs, preferentially targeting DYRK1A, and inhibits DYRK2.Formula:C17H13N3O3Purity:99.08%Color and Shape:SolidMolecular weight:307.3Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Formula:C18H17N5O3SPurity:98%Color and Shape:SolidMolecular weight:383.42ML167
CAS:ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.Formula:C19H17N3O3Purity:100% - 98.85%Color and Shape:SolidMolecular weight:335.36Ref: TM-T2670
2mg34.00€5mg49.00€10mg74.00€25mg142.00€50mg235.00€100mg349.00€200mg497.00€1mL*10mM (DMSO)49.00€YK-2-69
CAS:YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.Formula:C25H27FN8OSPurity:98.45% - 99.57%Color and Shape:SolidMolecular weight:506.6ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Formula:C14H15NO3SPurity:97.19%Color and Shape:SolidMolecular weight:277.34ML 315
CAS:ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.Formula:C18H13Cl2N3O2Purity:99.08%Color and Shape:SolidMolecular weight:374.22GSK-626616
CAS:GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.Formula:C18H10Cl2N4OSPurity:98.27%Color and Shape:SolidMolecular weight:401.27DYRKs-IN-1
CAS:DYRKs-IN-1 has antitumor activity.Formula:C30H30ClN7O4Purity:98%Color and Shape:SolidMolecular weight:588.06INDY
CAS:INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.Formula:C12H13NO2SPurity:98.15%Color and Shape:SolidMolecular weight:235.3
