PKC
PKC (Protein Kinase C) inhibitors target the PKC family of serine/threonine kinases, which are involved in a wide range of cellular processes, including cell cycle regulation, apoptosis, and differentiation. PKC plays a key role in signal transduction pathways that influence cell proliferation and survival. Inhibiting PKC can lead to changes in cell cycle progression, making these inhibitors valuable in research related to cancer, neurobiology, and cardiovascular diseases. At CymitQuimica, we provide a diverse selection of high-quality PKC inhibitors to support your research in signal transduction, cell cycle regulation, and therapeutic development.
Products of "PKC"
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VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formula:C20H24ClFN6OPurity:99.49%Color and Shape:SolidMolecular weight:418.9Ref: TM-T13314
1mg93.00€2mg125.00€5mg244.00€10mg364.00€25mg562.00€50mg780.00€100mg1,035.00€1mL*10mM (DMSO)225.00€Ruboxistaurin hydrochloride
CAS:Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formula:C28H28N4O3·HClPurity:98.44% - 99.22%Color and Shape:SolidMolecular weight:505.01Ref: TM-T3689
1mg71.00€2mg93.00€5mg157.00€10mg256.00€25mg513.00€50mg740.00€100mg1,035.00€500mg2,072.00€1mL*10mM (DMSO)202.00€K-252b
CAS:K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.Formula:C26H19N3O5Purity:98%Color and Shape:Ready-To-Use SolutionMolecular weight:453.45Delcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Formula:C120H199N45O34S2Purity:99.96%Color and Shape:SolidMolecular weight:2880.28Ref: TM-T11740
1mg202.00€5mg512.00€10mg740.00€25mg1,121.00€50mg1,539.00€100mg2,072.00€1mL*10mM (DMSO)1,691.00€1-Oleoyl-2-acetyl-sn-glycerol
CAS:1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.Formula:C23H42O5Color and Shape:SolidMolecular weight:398.58Hispidin
CAS:Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective propertiesFormula:C13H10O5Purity:98.27%Color and Shape:White Crystalline PowderMolecular weight:246.22Ref: TM-T7792
1mg88.00€5mg187.00€10mg298.00€25mg533.00€50mg747.00€100mg1,017.00€1mL*10mM (DMSO)207.00€A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Formula:C12H14Cl2N2O2SPurity:99.32%Color and Shape:SolidMolecular weight:321.22Ref: TM-T14069
1mg35.00€5mg66.00€10mg96.00€25mg170.00€50mg274.00€100mg439.00€500mg938.00€1mL*10mM (DMSO)90.00€(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Color and Shape:Odour Solid20-HETE
CAS:20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.Formula:C20H32O3Purity:99.79%Color and Shape:SolidMolecular weight:320.47Ref: TM-T14021
1mg (312.04μM*10mL in Ethanol)1,139.00€5mg (312.04μM*50mL in Ethanol)2,327.00€100μg (312.04μM*1mL in Ethanol)474.00€PKCiota-IN-2
CAS:PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Formula:C24H21N5OPurity:99.74%Color and Shape:SolidMolecular weight:395.46Ref: TM-T9863
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€1mL*10mM (DMSO)279.00€Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)Formula:C18H18Cl3FN4OSPurity:99.96%Color and Shape:SolidMolecular weight:463.8Ref: TM-T7885
2mg52.00€5mg74.00€10mg95.00€25mg163.00€50mg253.00€100mg437.00€200mg568.00€1mL*10mM (DMSO)86.00€N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Formula:C25H28ClNOPurity:99.15%Color and Shape:SolidMolecular weight:393.95Ref: TM-T12148
2mg35.00€5mg52.00€10mg78.00€25mg139.00€50mg202.00€100mg305.00€200mg426.00€1mL*10mM (DMSO)52.00€Bisindolylmaleimide I
CAS:Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.Formula:C25H24N4O2Purity:98.19% - 99.08%Color and Shape:Orange SolidMolecular weight:412.48PKC-θ inhibitor 1
CAS:PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Formula:C17H15F3N4OPurity:98%Color and Shape:SolidMolecular weight:348.32SAMβA TFA
SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improvesFormula:C50H73N17O16·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:1168.22 (free acid)(±)-1,2-Diolein
CAS:(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Formula:C39H72O5Color and Shape:SolidMolecular weight:620.99Phorbol 12-myristate 13-acetate
CAS:Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Formula:C36H56O8Purity:100% - 99.5%Color and Shape:White To Off-White SolidMolecular weight:616.83SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Formula:C17H22ClNO2SPurity:99.24% - 99.58%Color and Shape:SolidMolecular weight:339.88CGP 53353
CAS:CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.Formula:C20H13F2N3O2Purity:98.11%Color and Shape:SolidMolecular weight:365.33PKC-θ inhibitor
CAS:PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Formula:C20H25F3N6O3Purity:98%Color and Shape:SolidMolecular weight:454.45Ref: TM-T5423
1mg106.00€5mg250.00€10mg329.00€25mg467.00€50mg612.00€100mg944.00€200mg1,264.00€1mL*10mM (DMSO)274.00€Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formula:C12H15N5O5Purity:98.11%Color and Shape:SolidMolecular weight:309.28Ref: TM-T9605
1mg126.00€5mg274.00€10mg416.00€25mg677.00€50mg944.00€100mg1,264.00€1mL*10mM (DMSO)360.00€Valrubicin
CAS:Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.Formula:C34H36F3NO13Purity:98.63%Color and Shape:SolidMolecular weight:723.64D-ERYTHRO-SPHINGOSINE
CAS:D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activatorFormula:C18H37NO2Purity:98% - ≥98%Color and Shape:SolidMolecular weight:299.49Dioleyl phosphatidylserine
CAS:Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.Formula:C42H78NO10PColor and Shape:SolidMolecular weight:788.04Decursin
CAS:Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.Formula:C19H20O5Purity:100% - 97.22%Color and Shape:SolidMolecular weight:328.36Ref: TM-T3S1416
1mg43.00€5mg88.00€10mg119.00€25mg259.00€50mg462.00€100mg662.00€500mg1,359.00€1mL*10mM (DMSO)87.00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14Go6976
CAS:Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Formula:C24H18N4OPurity:95.89%Color and Shape:Off-White To Yellow SolidMolecular weight:378.43Protein kinase inhibitor H-7
CAS:H-7: potent PKC inhibitor with 6 μM Ki, also blocks cyclic nucleotide-dependent kinases.Formula:C14H17N3O2SPurity:99.69%Color and Shape:SoildMolecular weight:291.37Rottlerin
CAS:Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.Formula:C30H28O8Purity:97.41% - 99.44%Color and Shape:Orange To Brown PowderMolecular weight:516.54Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormula:C28H26N4O3Purity:99.24% - 99.98%Color and Shape:Off-White PowderMolecular weight:466.53Ref: TM-T6680
1mg62.00€2mg87.00€5mg97.00€10mg145.00€25mg246.00€50mg401.00€100mg597.00€500mg1,283.00€1mL*10mM (DMSO)109.00€Hypocrellin A
CAS:Hypocrellin A is a natural PKC inhibitor with light-induced antitumor, antifungal and antiviral activities.Cost-effective and quality-assured.Formula:C30H26O10Purity:98% - 99.81%Color and Shape:SolidMolecular weight:546.52(-)-Indolactam V
CAS:(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Formula:C17H23N3O2Purity:98%Color and Shape:SolidMolecular weight:301.38K-252c
CAS:K-252c is a staurosporine analog isolated from Nocardiopsis sp.Formula:C20H13N3OPurity:98%Color and Shape:SolidMolecular weight:311.34NSC668394
CAS:NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Formula:C17H12Br2N2O3Purity:99.29% - 99.29%Color and Shape:SolidMolecular weight:452.1PKC-θ inhibitor hcl
CAS:PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).Formula:C20H26ClF3N6O3Purity:98.93%Color and Shape:SolidMolecular weight:490.91Ref: TM-T5817
1mg93.00€2mg120.00€5mg233.00€10mg376.00€25mg628.00€50mg895.00€100mg1,216.00€500mg2,432.00€Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Formula:C69H122N26O18Purity:100%Color and Shape:SolidMolecular weight:1603.9Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37Taurolithocholic acid sodium salt
CAS:Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFormula:C26H44NNaO5SPurity:99.79% - 99.93%Color and Shape:SolidMolecular weight:505.69Verbascoside
CAS:Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.Formula:C29H36O15Purity:97.46% - 99.55%Color and Shape:SolidMolecular weight:624.59TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:≥98%Color and Shape:SolidMolecular weight:526.51Ro 31-8220 Mesylate
CAS:Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Formula:C25H23N5O2S·CH4O3SPurity:98.79% - 99.02%Color and Shape:SolidMolecular weight:553.65Ref: TM-T6643
1mg52.00€2mg67.00€5mg97.00€10mg159.00€25mg244.00€50mg338.00€100mg500.00€1mL*10mM (DMSO)140.00€Chelerythrine chloride
CAS:Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect toFormula:C21H18ClNO4Purity:95% - 99.19%Color and Shape:Yellow To Orange SolidMolecular weight:383.83Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formula:C4H3AuNa2O4SPurity:99.66%Color and Shape:SoildMolecular weight:390.07AS2521780
CAS:AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Formula:C30H41N7OSPurity:98%Color and Shape:SolidMolecular weight:547.76CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formula:C24H21F3N6OPurity:98.34% - 99.01%Color and Shape:SolidMolecular weight:466.46TPPB
CAS:TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).Formula:C27H30F3N3O3Purity:98.00%Color and Shape:SolidMolecular weight:501.54DCP-LA
CAS:DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.Formula:C20H36O2Purity:98%Color and Shape:SolidMolecular weight:308.5
