ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Products of "ROCK"
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Netarsudil mesylate
CAS:Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Formula:C30H35N3O9S2Purity:99.7%Color and Shape:SolidMolecular weight:645.74ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formula:C18H12N6OSPurity:98.45%Color and Shape:SolidMolecular weight:360.39Ref: TM-T12747
1mg52.00€5mg117.00€10mg187.00€25mg320.00€50mg472.00€100mg730.00€200mg938.00€1mL*10mM (DMSO)143.00€Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formula:C28H29Cl2N3O3Purity:99.94% - 99.98%Color and Shape:SolidMolecular weight:526.45BDP9066
CAS:BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formula:C20H24N6Purity:98.18%Color and Shape:SolidMolecular weight:348.44Ref: TM-T14521
1mg57.00€5mg120.00€10mg188.00€25mg432.00€50mg747.00€100mg1,293.00€500mg2,585.00€1mL*10mM (DMSO)133.00€SB-747651A Dihydrochloride
CAS:SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Formula:C16H24Cl2N8OPurity:97.02%Color and Shape:SolidMolecular weight:415.32Ref: TM-T9652
1mg73.00€5mg155.00€10mg220.00€25mg369.00€50mg525.00€100mg712.00€500mgTo inquire1mL*10mM (DMSO)169.00€Verosudil
CAS:Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formula:C17H17N3O2SPurity:99.72%Color and Shape:SolidMolecular weight:327.4Ref: TM-T60924
1mg87.00€5mg250.00€10mg406.00€25mg652.00€50mg919.00€100mg1,216.00€1mL*10mM (DMSO)274.00€CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFormula:C23H19ClF2N2O3Purity:98.76%Color and Shape:SolidMolecular weight:444.86Ref: TM-T7764
2mg42.00€5mg65.00€10mg99.00€25mg182.00€50mg279.00€100mg414.00€200mg587.00€1mL*10mM (DMSO)70.00€SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormula:C14H17ClN2O2Purity:98.01%Color and Shape:SolidMolecular weight:280.75URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 - MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formula:C27H27N5Purity:98.43% - 99.32%Color and Shape:SolidMolecular weight:421.54ROCK inhibitor-2
CAS:ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formula:C21H20N2O2Purity:99.85%Color and Shape:SolidMolecular weight:332.4Ref: TM-T12746
1mg66.00€5mg144.00€10mg216.00€25mg432.00€50mg645.00€100mg905.00€1mL*10mM (DMSO)106.00€ROCK2-IN-7
CAS:ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.Formula:C26H28FN5OPurity:98%Color and Shape:SolidMolecular weight:445.53GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Formula:C29H30N8O5Purity:99.14% - 99.71%Color and Shape:SolidMolecular weight:570.6BDP5290
CAS:BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)Formula:C17H18ClN7OPurity:97.22%Color and Shape:SolidMolecular weight:371.82Ref: TM-T7301
1mg56.00€2mg81.00€5mg119.00€10mg188.00€25mg389.00€50mg565.00€100mg822.00€1mL*10mM (DMSO)131.00€ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formula:C19H22N4O3SColor and Shape:SolidMolecular weight:386.47H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Formula:C16H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:319.42ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Formula:C20H20FN5O2Purity:98%Color and Shape:SolidMolecular weight:381.4CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formula:C26H23N3O5Purity:99.04%Color and Shape:SolidMolecular weight:457.48Ref: TM-T36196
1mg35.00€5mg81.00€10mg117.00€25mg259.00€50mg393.00€100mg620.00€200mg832.00€1mL*10mM (DMSO)81.00€ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formula:C28H30N8O2Color and Shape:SolidMolecular weight:510.59ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂,适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formula:C26H22ClF2N7OPurity:98%Color and Shape:SolidMolecular weight:521.95
