HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Products of "HSP"
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2',4'-DIHYDROXYCHALCONE
CAS:2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effectsFormula:C15H12O3Purity:98.95%Color and Shape:SolidMolecular weight:240.25Ref: TM-T8829
2mg42.00€5mg62.00€10mg87.00€25mg154.00€50mg235.00€100mg354.00€200mg520.00€1mL*10mM (DMSO)65.00€Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purity:95.32% - 98.46%Color and Shape:SolidMolecular weight:505.56Feretoside
CAS:Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).Formula:C17H24O11Purity:99.15%Color and Shape:SolidMolecular weight:404.37Ref: TM-TQ0280
1mg85.00€5mg180.00€10mg274.00€25mg465.00€50mg663.00€100mg919.00€500mg1,833.00€1mL*10mM (DMSO)298.00€PU-H54
CAS:PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.Formula:C18H19N5SPurity:99.13%Color and Shape:SolidMolecular weight:337.44PF04929113
CAS:PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.Formula:C25H30F3N5O4Purity:99.06%Color and Shape:SolidMolecular weight:521.53Ref: TM-T6341
1mg39.00€2mg49.00€5mg84.00€10mg119.00€25mg187.00€50mg354.00€100mg527.00€1mL*10mM (DMSO)96.00€HSP90-IN-19
CAS:HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.Formula:C29H38O7Purity:98%Color and Shape:SolidMolecular weight:498.61HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formula:C33H40N2O4Color and Shape:SolidMolecular weight:528.68NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formula:C22H22N4O7Purity:99.82%Color and Shape:SolidMolecular weight:454.43Ref: TM-T6609
2mg42.00€5mg64.00€10mg97.00€25mg197.00€50mg310.00€100mg442.00€200mg622.00€1mL*10mM (DMSO)70.00€Calenduloside E
CAS:Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and byFormula:C36H56O9Purity:96.16%Color and Shape:SolidMolecular weight:632.822-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Formula:C11H18O2Purity:98%Color and Shape:SolidMolecular weight:182.26Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formula:C28H34O7Purity:99.38% - 99.68%Color and Shape:SolidMolecular weight:482.57Ref: TM-T21883
1mg393.00€5mg1,169.00€10mg1,596.00€25mg2,365.00€50mg3,192.00€100mg4,304.00€1mL*10mM (DMSO)1,283.00€NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFormula:C28H32N2O3SPurity:98%Color and Shape:SolidMolecular weight:476.63TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90.Formula:C45H39F7N2O4P2Purity:98%Color and Shape:SolidMolecular weight:866.74HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Formula:C29H48O10Purity:98%Color and Shape:SolidMolecular weight:556.69KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85PU-H71 HCl
CAS:PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.Formula:C18H22ClIN6O2SPurity:98.95%Color and Shape:SoildMolecular weight:548.83Hsp90-IN-38
CAS:Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.Formula:C28H35N3O5Color and Shape:SolidMolecular weight:493.595TRC051384
CAS:TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Formula:C25H31N5O4Purity:92.66%Color and Shape:SolidMolecular weight:465.54Ref: TM-T3527
1mg37.00€5mg80.00€10mg111.00€25mg210.00€50mg298.00€100mg432.00€200mg622.00€1mL*10mM (DMSO)81.00€Geldanamycin
CAS:Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Formula:C29H40N2O9Purity:98.83% - 99.27%Color and Shape:Yellow To Orange PowderMolecular weight:560.64KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Formula:C13H12N6O2Purity:97.25% - 99.91%Color and Shape:SolidMolecular weight:284.27Ref: TM-T3652
5mg51.00€10mg77.00€25mg159.00€50mg263.00€100mg510.00€200mg717.00€500mg1,093.00€1mL*10mM (DMSO)52.00€Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Formula:C46H62N4O11Purity:99.27% - 99.8%Color and Shape:Red-Violet Crystalline PowderMolecular weight:847Tasiamide B
CAS:Tasiamide B is a linear peptide and Cathepsin D inhibitor discovered in the marine cyanobacterium Symploca sp. This compound serves as an excellent template for the development of aspartic protease inhibitors. Tasiamide B effectively targets skin cancer through its strong interaction with the protein HSP90.Formula:C50H74N8O12Color and Shape:SolidMolecular weight:979.17AMP-PCP
CAS:AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Formula:C11H18N5O12P3Purity:98%Color and Shape:SolidMolecular weight:505.212-Methoxyhydroquinone
CAS:2-Methoxyhydroquinone is a phenolic compound that reduces the production of TNF-α-induced chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. It also serves as a synthetic precursor to the Hsp90 inhibitor Geldanamycin.Formula:C7H8O3Color and Shape:SolidMolecular weight:140.14MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Formula:C21H22ClN3OS2Purity:98.2%Color and Shape:SolidMolecular weight:432BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formula:C14H15ClN6OPurity:98% - 99.82%Color and Shape:SolidMolecular weight:318.763-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Formula:C13H11N5O2Purity:98.84%Color and Shape:SolidMolecular weight:269.26Ref: TM-T36123
1mg57.00€5mg120.00€10mg187.00€25mg338.00€50mg512.00€100mg753.00€200mg1,035.00€1mL*10mM (DMSO)133.00€CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Formula:C19H18ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:415.9TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Formula:C25H32ClN5O4Purity:97.55%Color and Shape:SolidMolecular weight:502.01AMP-PCP disodium
CAS:AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Formula:C11H16N5Na2O12P3Purity:100%Color and Shape:SolidMolecular weight:549.17VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formula:C21H23Cl2N5O2SPurity:98% - 99.16%Color and Shape:SolidMolecular weight:480.41HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Formula:C27H33N5O5Color and Shape:SolidMolecular weight:507.58KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formula:C13H11NO4Purity:98.90%Color and Shape:SolidMolecular weight:245.23H2-Gamendazole
CAS:H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Formula:C18H13Cl2F3N2O2Purity:97.36%Color and Shape:SolidMolecular weight:417.21Ref: TM-T72076
1mg78.00€5mg190.00€10mg284.00€25mg505.00€50mg677.00€100mg929.00€200mg1,225.00€1mL*10mM (DMSO)215.00€CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Formula:C22H20ClN5O3SPurity:99.51%Color and Shape:SolidMolecular weight:469.94Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurity:98.98%Color and Shape:SolidMolecular weight:442.58NCT-58
CAS:NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Formula:C27H34N2O5Purity:98.75%Color and Shape:SolidMolecular weight:466.57Ref: TM-T9996
2mg46.00€5mg85.00€10mg126.00€25mg259.00€50mg415.00€100mg662.00€200mg889.00€1mL*10mM (DMSO)207.00€Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Formula:C26H31N3O5Purity:98% - 99.26%Color and Shape:SolidMolecular weight:465.54Ref: TM-T1989
5mg57.00€10mg81.00€25mg145.00€50mg221.00€100mg363.00€200mg540.00€500mg872.00€1mL*10mM (DMSO)63.00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formula:C21H19N3O2S2Purity:98.89%Color and Shape:SolidMolecular weight:409.52Ref: TM-T4125
1mg55.00€2mg88.00€5mg139.00€10mg207.00€25mg462.00€50mg677.00€100mg938.00€1mL*10mM (DMSO)130.00€Chetomin
CAS:Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolarFormula:C31H30N6O6S4Purity:98%Color and Shape:Off-White To Fawn SolidMolecular weight:710.87SNX2112
CAS:SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.Formula:C23H27F3N4O3Purity:98.9% - 99.46%Color and Shape:SolidMolecular weight:464.48Ref: TM-T6305
1mg40.00€5mg85.00€10mg127.00€25mg220.00€50mg334.00€100mg477.00€200mg662.00€1mL*10mM (DMSO)87.00€CCT251236
CAS:CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Formula:C32H32N4O5Purity:98.82% - 99.89%Color and Shape:SolidMolecular weight:552.62Ref: TM-T14905
1mg39.00€5mg116.00€10mg221.00€25mg457.00€50mg733.00€100mg1,111.00€200mg1,501.00€1mL*10mM (DMSO)144.00€HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFormula:C13H12O4SPurity:99.51%Color and Shape:SolidMolecular weight:264.3Ref: TM-T7265
1mg130.00€2mg185.00€5mg311.00€10mg472.00€25mg753.00€50mg1,064.00€100mg1,415.00€1mL*10mM (DMSO)455.00€HSP70-IN-1
CAS:HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).Formula:C24H28N6O2SPurity:100%Color and Shape:SolidMolecular weight:464.58Ref: TM-T3487
1mg96.00€5mg227.00€10mg354.00€25mg620.00€50mg847.00€100mg1,169.00€1mL*10mM (DMSO)230.00€Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formula:C14H11NO4Purity:98.67% - 99.03%Color and Shape:SolidMolecular weight:257.24Ref: TM-T10860
2mg47.00€5mg70.00€10mg107.00€25mg216.00€50mg350.00€100mg542.00€200mg778.00€500mg1,169.00€1mL*10mM (DMSO)70.00€Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Formula:C24H30O9Purity:98.18% - 99.22%Color and Shape:SolidMolecular weight:462.49NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Formula:C20H18FN5O2Purity:97.63% - 99.32%Color and Shape:SolidMolecular weight:379.39BX-2819
CAS:BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Formula:C21H24N4O4SPurity:98%Color and Shape:SolidMolecular weight:428.51EC 144
CAS:EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Formula:C21H24ClN5O2Color and Shape:SolidMolecular weight:413.9YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formula:C21H19ClN2O4Purity:97.25%Color and Shape:SolidMolecular weight:398.84Ref: TM-T8901
1mg48.00€5mg96.00€10mg135.00€25mg264.00€50mg389.00€100mg553.00€200mg750.00€1mL*10mM (DMSO)96.00€
