Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Products of "Sirtuin"
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Found 93 products on this category.
SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purity:98.96% - 99.75%Color and Shape:SolidMolecular weight:420.55Ref: TM-T6984
1mg39.00€2mg50.00€5mg79.00€10mg107.00€25mg197.00€50mg311.00€100mg505.00€1mL*10mM (DMSO)90.00€Splitomicin
CAS:Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in aFormula:C13H10O2Purity:98.64% - 99.11%Color and Shape:SolidMolecular weight:198.22Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurity:98.53% - 99.79%Color and Shape:SolidMolecular weight:248.71Ref: TM-T6111
5mg50.00€10mg57.00€25mg93.00€50mg140.00€100mg235.00€200mg349.00€500mg565.00€1mL*10mM (DMSO)52.00€WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formula:C20H23ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:406.93YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.Formula:C44H70O16Purity:99.13%Color and Shape:SolidMolecular weight:855.02MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Formula:C22H19N3OSPurity:99.9%Color and Shape:SolidMolecular weight:373.47SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formula:C40H54N8O6SPurity:98%Color and Shape:SolidMolecular weight:774.97YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Ref: TM-T9320
2mg40.00€5mg60.00€10mg87.00€25mg180.00€50mg305.00€100mg535.00€200mg690.00€500mg1,074.00€1mL*10mM (DMSO)66.00€SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purity:98%Color and Shape:SolidMolecular weight:401.35SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Color and Shape:Odour SolidJGB1741
CAS:JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.Formula:C27H24N2O2SPurity:97.24%Color and Shape:SolidMolecular weight:440.56SIRT5 inhibitor 6
CAS:SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential forFormula:C21H28N6O4SPurity:99.82%Color and Shape:SolidMolecular weight:460.55SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formula:C14H16N2OPurity:99.31%Color and Shape:SolidMolecular weight:228.29Ref: TM-T9648
1mg96.00€5mg202.00€10mg311.00€25mg533.00€50mg747.00€100mg1,017.00€200mg1,359.00€1mL*10mM (DMSO)207.00€Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.47%Color and Shape:SolidMolecular weight:349.41Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurity:98.47% - 99.83%Color and Shape:SolidMolecular weight:360.43Ref: TM-T4019
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)66.00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurity:100% - 97.71%Color and Shape:SolidMolecular weight:454.63Ref: TM-T1818
1mg43.00€2mg56.00€5mg77.00€10mg87.00€25mg157.00€50mg230.00€100mg393.00€500mg930.00€1mL*10mM (DMSO)79.00€Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Purity:98%Color and Shape:Odour SolidSRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Formula:C25H24ClN7OSPurity:98% - 99.93%Color and Shape:SolidMolecular weight:506.22Ref: TM-T2412
1mg69.00€2mg89.00€5mg139.00€10mg250.00€25mg394.00€50mg562.00€100mg800.00€200mg1,103.00€500mg1,634.00€1mL*10mM (DMSO)221.00€Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Formula:C14H12O3Purity:99.53% - 99.9%Color and Shape:Off-White To Tan PowderMolecular weight:228.24Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formula:C37H46O12Purity:99.06% - ≥95%Color and Shape:SolidMolecular weight:682.753-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Formula:C7H6N4Purity:100% - 99.16%Color and Shape:SolidMolecular weight:146.15Ref: TM-T4108
5mg57.00€10mg87.00€25mg170.00€50mg261.00€100mg470.00€500mg1,064.00€1mL*10mM (DMSO)57.00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formula:C19H14N2O6Purity:97.47% - 99.25%Color and Shape:SolidMolecular weight:366.32Ref: TM-T4328
1mg46.00€2mg59.00€5mg93.00€10mg117.00€25mg235.00€50mg432.00€100mg638.00€500mg1,359.00€1mL*10mM (DMSO)93.00€MC2184
CAS:MC2184 is the inhibitor of human recombinant SIRT1.Formula:C11H6N2O3Purity:98%Color and Shape:SolidMolecular weight:214.18MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formula:C21H16BrCl2FN2O6S2Purity:100%Color and Shape:SolidMolecular weight:626.3BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormula:C24H25NO4Purity:100%Color and Shape:SolidMolecular weight:391.46Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.Formula:C13H13ClN2OPurity:99.69%Color and Shape:SolidMolecular weight:248.71Ref: TM-T7058
1mg150.00€2mg215.00€5mg331.00€10mg472.00€25mg753.00€50mg1,074.00€1mL*10mM (DMSO)379.00€CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurity:98.92%Color and Shape:SolidMolecular weight:418.44SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Formula:C15H21N5O3S2Purity:98.26%Color and Shape:SolidMolecular weight:383.49Ref: TM-T12919
1mg97.00€5mg227.00€10mg364.00€25mg620.00€50mg848.00€100mg1,159.00€200mg1,549.00€1mL*10mM (DMSO)250.00€MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Formula:C33H38N4O8Purity:98% - 99.48%Color and Shape:SoildMolecular weight:618.68Ref: TM-T11962
1mg52.00€2mg74.00€5mg111.00€10mg180.00€25mg283.00€50mg445.00€100mg723.00€500mg1,454.00€SIRT5 inhibitor 5
CAS:SIRT5 Inhibitor 5 is a potent substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 0.21 µM, and does not interact with the NAD+-binding pocket [1].Formula:C21H14ClN3O3SPurity:98%Color and Shape:SolidMolecular weight:423.87UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purity:99.75%Color and Shape:SolidMolecular weight:247.29Ref: TM-T7679
1mg40.00€5mg81.00€10mg116.00€25mg226.00€50mg324.00€100mg452.00€200mg632.00€1mL*10mM (DMSO)100.00€Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Formula:C11H15N2O5Purity:98.61% - 99.58%Color and Shape:SolidMolecular weight:255.25Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Formula:C26H22N2O2Purity:97.09% - 99.55%Color and Shape:SolidMolecular weight:394.47SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formula:C15H12ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:285.73Ref: TM-T39233
1mg96.00€5mg235.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€1mL*10mM (DMSO)259.00€SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formula:C23H23N3O6Color and Shape:SolidMolecular weight:437.45Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purity:98.06% - 99.87%Color and Shape:SolidMolecular weight:514.65AGK2
CAS:AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.Formula:C23H13Cl2N3O2Purity:98.68% - 99.17%Color and Shape:SolidMolecular weight:434.27SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Formula:C21H22N6OS2Purity:99.5%Color and Shape:SolidMolecular weight:438.57Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Formula:C16H18O9Purity:99.09% - ≥95%Color and Shape:SolidMolecular weight:354.31Tenovin-3
CAS:Tenovin-3 acts as a p53 activator.Formula:C18H21N3OSPurity:100% - ≥95%Color and Shape:SolidMolecular weight:327.44Ref: TM-T1873
1mg60.00€5mg126.00€10mg202.00€25mg432.00€50mg638.00€100mg908.00€500mg1,825.00€1mL*10mM (DMSO)140.00€Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Formula:C25H19N5OS2Purity:97.69% - 99.36%Color and Shape:SolidMolecular weight:469.58Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Formula:C20H15N3O2SPurity:99.02%Color and Shape:SolidMolecular weight:361.42SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Formula:C27H24N4O2SPurity:97.86%Color and Shape:SolidMolecular weight:468.57Ref: TM-T16932
1mg50.00€2mg72.00€5mg107.00€10mg165.00€25mg283.00€50mg430.00€100mg622.00€1mL*10mM (DMSO)111.00€SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Color and Shape:Odour SolidB2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purity:99.14%Color and Shape:SolidMolecular weight:396.83AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurity:98.32% - 99.44%Color and Shape:SolidMolecular weight:403.45HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Purity:98%Color and Shape:Odour SolidEpigenetic factor-IN-1
CAS:Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.Formula:C32H34FN5O6S2Purity:98%Color and Shape:SolidMolecular weight:667.77RK-9123016
CAS:RK-9123016 is a SIRT2 inhibitor.Formula:C16H18N6O3SPurity:100%Color and Shape:SolidMolecular weight:374.424'-bromo-Resveratrol
CAS:4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Formula:C14H11BrO2Purity:99.00%Color and Shape:SolidMolecular weight:291.14SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurity:99.93%Color and Shape:SolidMolecular weight:561.06SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Formula:C31H39FN6O6S2Purity:98.06%Color and Shape:SolidMolecular weight:674.81Ref: TM-T12921
1mg145.00€2mg207.00€5mg354.00€10mg530.00€25mg934.00€50mg1,359.00€100mg1,825.00€1mL*10mM (DMSO)465.00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09Ref: TM-T8480
1mg39.00€2mg51.00€5mg70.00€10mg88.00€25mg140.00€50mg226.00€100mg376.00€1mL*10mM (DMSO)73.00€Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Formula:C44H64O24Purity:98.24% - 98.82%Color and Shape:Orange Yellow To Reddish Yellow PowderMolecular weight:976.96Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Formula:C17H15FN2OPurity:99.63%Color and Shape:SolidMolecular weight:282.31Ref: TM-T77653
1mg57.00€2mg81.00€5mg120.00€10mg180.00€25mg329.00€50mg472.00€100mg700.00€500mg1,406.00€WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formula:C22H25ClN8O2SPurity:99.68%Color and Shape:SolidMolecular weight:501SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Formula:C55H91N9O15SColor and Shape:SolidMolecular weight:1150.43SIRT-IN-6
CAS:SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Formula:C7H4ClN3OSColor and Shape:SolidMolecular weight:213.644Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Formula:C34H51N3O3SPurity:99.16%Color and Shape:SolidMolecular weight:581.85Ref: TM-T3447
1mg57.00€2mg77.00€5mg96.00€10mg124.00€25mg227.00€50mg380.00€100mg567.00€1mL*10mM (DMSO)124.00€SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Formula:C19H14N2O6Purity:98.84%Color and Shape:SolidMolecular weight:366.32E1231
CAS:E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Formula:C21H21N3O3Purity:98.45%Color and Shape:SolidMolecular weight:363.41Ref: TM-T9106
1mg35.00€5mg73.00€10mg104.00€25mg207.00€50mg329.00€100mg475.00€500mg938.00€1mL*10mM (DMSO)89.00€Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Formula:C28H27N7O2S2Purity:99.05% - 99.15%Color and Shape:SolidMolecular weight:557.69Ref: TM-T12920
1mg105.00€5mg215.00€10mg340.00€25mg542.00€50mg735.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)266.00€Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Formula:C21H20N4O3S2Purity:98%Color and Shape:SolidMolecular weight:440.54Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purity:94.14% - 98.31%Color and Shape:Yellow To Brown Crystalline PowderMolecular weight:286.24AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Formula:C23H13Cl2N3O2Purity:98.31%Color and Shape:SolidMolecular weight:434.27SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Formula:C26H24N6O2S2Purity:97.03% - 99.83%Color and Shape:SolidMolecular weight:516.64Ref: TM-T6679
1g1,644.00€1mg46.00€5mg87.00€10mg131.00€25mg230.00€50mg378.00€100mg563.00€200mg805.00€500mg1,225.00€SIRT-IN-1
CAS:SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).Formula:C19H27N5O2SPurity:97.07%Color and Shape:SolidMolecular weight:389.52ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formula:C26H29I2NO3Purity:99.23%Color and Shape:SolidMolecular weight:657.32Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.48SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating proteinFormula:C28H32ClN7O3SPurity:99.77%Color and Shape:SolidMolecular weight:582.12MDL-811
CAS:MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),Formula:C25H25BrCl2FN3O5S2Purity:98%Color and Shape:SolidMolecular weight:681.42SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Formula:C18H23NO4Purity:98%Color and Shape:SolidMolecular weight:317.38Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formula:C31H32ClN5O2S2Purity:99.1%Color and Shape:SolidMolecular weight:606.2SRT 1720 dihydrochloride
CAS:SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Formula:C25H25Cl2N7OSPurity:98.43%Color and Shape:SolidMolecular weight:542.48Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Formula:C26H22N2O2Purity:99.52% - 99.96%Color and Shape:SolidMolecular weight:394.47Ref: TM-T6671
2mg43.00€5mg58.00€10mg93.00€25mg178.00€50mg343.00€100mg509.00€500mg1,121.00€1mL*10mM (DMSO)58.00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Formula:C19H21BrN2O3SPurity:98.43% - 99.34%Color and Shape:SolidMolecular weight:437.35Ref: TM-T5490
1mg37.00€2mg49.00€5mg74.00€10mg105.00€25mg187.00€50mg329.00€100mg540.00€1mL*10mM (DMSO)94.00€SRT 1460
CAS:SRT 1460 is a SIRT1 activator.Formula:C26H29N5O4SPurity:98.25%Color and Shape:SolidMolecular weight:507.6Et-29
CAS:Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.Formula:C34H46N6O6SPurity:98.69%Color and Shape:SolidMolecular weight:666.83Sirt1/2-IN-3
CAS:Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively.Formula:C17H14ClNO4SPurity:98%Color and Shape:SolidMolecular weight:363.82SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurity:99.78%Color and Shape:SolidMolecular weight:248.71Ref: TM-T15263
1mg106.00€2mg159.00€5mg259.00€10mg376.00€25mg630.00€50mg880.00€100mg1,169.00€1mL*10mM (DMSO)284.00€Dihydrocoumarin
CAS:Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).Formula:C9H8O2Purity:98.46%Color and Shape:Leaflets Room Temperature (Ntp 1992)Molecular weight:148.16Sirt1/2-IN-2
CAS:Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively.Formula:C18H14N4O3S2Purity:98%Color and Shape:SolidMolecular weight:398.46SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormula:C21H30Br3ClN6SPurity:98%Color and Shape:SolidMolecular weight:673.73Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formula:C28H46N8O6SColor and Shape:SolidMolecular weight:622.78SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Formula:C20H24O11Purity:99.71% - 99.98%Color and Shape:White PowderMolecular weight:440.4MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Formula:C25H25NO6Purity:99.57%Color and Shape:SolidMolecular weight:435.47Ref: TM-T88662
1mg52.00€5mg100.00€10mg156.00€25mg302.00€50mg492.00€100mg749.00€200mg999.00€1mL*10mM (DMSO)105.00€Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formula:C20H17N3O2Purity:99.1%Color and Shape:SolidMolecular weight:331.37
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