NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
Sort by
SZM-1209
CAS:SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM.Formula:C31H29F5N4O5S2Purity:98%Color and Shape:SolidMolecular weight:696.71Penehyclidine hydrochloride
CAS:Penehyclidine hydrochloride: M1/M3 antagonist, activates NF-κB, anti-inflammatory, anticholinergic.Formula:C20H30ClNO2Purity:99.7%Color and Shape:SolidMolecular weight:351.91Isophysalin A
CAS:Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) productionFormula:C28H30O10Purity:98%Color and Shape:SolidMolecular weight:526.53NT-0796
CAS:NT-0796 is an inflammasome NLRP3 inhibitor that inhibits NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector.Formula:C23H27N3O4Purity:99.67%Color and Shape:SolidMolecular weight:409.48DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Color and Shape:SolidMolecular weight:525.6IMD-vanillin
CAS:IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.Formula:C37H45N7O4Purity:98%Color and Shape:SolidMolecular weight:651.8Ethacrynic acid
CAS:Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂,也是NF-κB 信号传导途径的有效抑制剂,并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道,从而导致气道平滑肌细胞松弛。它是利尿剂,具有抗炎特性,可减轻类维生素 A 诱导的小鼠耳部水肿。Formula:C13H12Cl2O4Purity:100% - 99.15%Color and Shape:Crystals Physical Description White Solid (Ntp 1992)Molecular weight:303.14Zharp1-211
CAS:Zharp1-211 is a RIPK3 inhibitor,reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Formula:C24H25N5O4Purity:99.71%Color and Shape:SolidMolecular weight:447.494-Hydroxychalcone
CAS:4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.Formula:C15H12O2Purity:99.75%Color and Shape:Yellow PowderMolecular weight:224.25Forsythoside B
CAS:Forsythoside B inhibits LPS, NF-κB, inflammation, offers neuroprotection, reduces ischemia injury, and has antioxidant and antisepsis effects.Formula:C34H44O19Purity:98% - 98.78%Color and Shape:SolidMolecular weight:756.7GSK-843
CAS:GSK-843 (GSK'843) is a RIP3 inhibitor with analgesic activity, inhibits RIP3 expression, and can be used as an adjunctive treatment for inflammation.Formula:C19H15N5S2Purity:99.18%Color and Shape:SolidMolecular weight:377.49Sanggenon C
CAS:Sanggenon C inhibits NF-κB activity, the expression of inducible nitric oxide synthase, tumor necrosis factor-α-stimulated cell adhesion and the expression of vascular cell adhesion molecule-1 in RAW264.7 cells. Cost-effective and quality-assured.Formula:C40H36O12Purity:97.76% - 98.54%Color and Shape:SolidMolecular weight:708.71Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurity:98.35% - 99.95%Color and Shape:Needles From Benzene Or Alcohol SolidMolecular weight:234.344-O-Methyl honokiol
CAS:4-O-Methyl honokiol (4-O-Methylhonokiol), derived from Magnolia officinalis and Magnolia officinalis, is a PPARγ agonist with antiangiogenic properties.Formula:C19H20O2Purity:99.31%Color and Shape:SolidMolecular weight:280.36Ref: TM-T10153
1mg57.00€5mg120.00€10mg187.00€25mg354.00€50mg528.00€100mg758.00€500mg1,568.00€1mL*10mM (DMSO)131.00€IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Formula:C28H29N5OSPurity:98.76% - 99.61%Color and Shape:SolidMolecular weight:483.63Ref: TM-T6176
1mg40.00€2mg52.00€5mg88.00€10mg139.00€25mg245.00€50mg406.00€100mg607.00€200mg845.00€1mL*10mM (DMSO)87.00€CA-4948
CAS:CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.Formula:C24H25N7O5Purity:99.62%Color and Shape:SolidMolecular weight:491.5Ref: TM-T9027
1mg35.00€2mg52.00€5mg77.00€10mg87.00€25mg170.00€50mg311.00€100mg535.00€1mL*10mM (DMSO)84.00€Lobeglitazone Sulfate
CAS:Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.Formula:C24H26N4O9S2Purity:98.69%Color and Shape:SolidMolecular weight:578.61Laquinimod
CAS:Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oralFormula:C19H17ClN2O3Purity:98.16% - 98.84%Color and Shape:SolidMolecular weight:356.8RI-962
CAS:RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.Formula:C28H28N6O2Purity:99.39%Color and Shape:SoildMolecular weight:480.56Berbamine
CAS:Berbamine is a natural product extracted from Phellodendron amurense.Formula:C37H40N2O6Purity:98.92% - 99.64%Color and Shape:White Crystal PowderMolecular weight:608.72PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purity:98.82%Color and Shape:SolidMolecular weight:394.47Geranylgeraniol
CAS:Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice.Formula:C20H34OPurity:99.89% - ≥98%Color and Shape:SolidMolecular weight:290.48Triacetylresveratrol
CAS:Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.Formula:C20H18O6Purity:99.81%Color and Shape:Off White PowderMolecular weight:354.35Suberosin
CAS:Suberosin: anti-inflammatory, anticoagulant, deters Aedes aegypti bites, potential mosquito larvicide.Formula:C15H16O3Purity:97.08% - 99.12%Color and Shape:SolidMolecular weight:244.298-Deoxygartanin
CAS:8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it hasFormula:C23H24O5Purity:99.04% - 99.76%Color and Shape:SolidMolecular weight:380.43Madecassic acid
CAS:Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.Formula:C30H48O6Purity:98.80% - 99.69%Color and Shape:SolidMolecular weight:504.7Anti-osteoporosis agent-4
Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis.Formula:C26H26ClN3O7SPurity:98%Color and Shape:SolidMolecular weight:560.02QNZ
CAS:QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.Formula:C22H20N4OPurity:98.16% - 99.17%Color and Shape:White SolidMolecular weight:356.42Ref: TM-T6204
1mg43.00€2mg57.00€5mg93.00€10mg140.00€25mg226.00€50mg329.00€100mg490.00€1mL*10mM (DMSO)93.00€IKKγ NBD Inhibitory Peptide acetate
IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region.Purity:99.15%Color and Shape:SolidMolecular weight:N/ARef: TM-TP1615L
1mg131.00€2mg173.00€5mg255.00€10mg374.00€25mg625.00€50mg890.00€100mg1,206.00€500mg2,422.00€IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Formula:C22H26ClN3O4Purity:98%Color and Shape:SolidMolecular weight:431.91Okanin
CAS:Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.Formula:C15H12O6Purity:95.19% - 99.4%Color and Shape:SolidMolecular weight:288.25Ref: TM-TN2008
1mg88.00€5mg259.00€10mg311.00€25mg525.00€50mg750.00€100mg1,017.00€1mL*10mM (DMSO)217.00€RIP1 kinase inhibitor 7
CAS:RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM.Formula:C20H20FN3OPurity:98%Color and Shape:SolidMolecular weight:337.39Barlerin
CAS:Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and protective effect on oxygen-glucose deprivation-induced injuryFormula:C19H28O12Purity:99.83% - ≥95%Color and Shape:SolidMolecular weight:448.42Ref: TM-T5S1632
1mg40.00€2mg52.00€5mg85.00€10mg115.00€25mg245.00€50mg354.00€100mg533.00€1mL*10mM (DMSO)92.00€14-Deoxy-11,12-didehydroandrographolide
CAS:14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.Formula:C20H28O4Purity:98.55% - 99.93%Color and Shape:SolidMolecular weight:332.43Ref: TM-TQ0185
1mg69.00€5mg187.00€10mg274.00€25mg465.00€50mg677.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)145.00€SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Formula:C14H5ClF9N3OPurity:99.57%Color and Shape:SolidMolecular weight:437.65Ref: TM-T24816
1mg35.00€5mg73.00€10mg104.00€25mg243.00€50mg378.00€100mg542.00€500mgTo inquire1mL*10mM (DMSO)82.00€RIPK1-IN-25
RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.Color and Shape:Odour SolidGanoderic acid H
CAS:Ganoderic acid H inhibits AP-1/NF-κB, suppressing uPA to exert antitumor effects.Formula:C32H44O9Purity:95% - 97.14%Color and Shape:SolidMolecular weight:572.69Galloylpaeoniflorin
CAS:Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress.Formula:C30H32O15Purity:97.1%Color and Shape:SolidMolecular weight:632.57Necrostatin 2 racemate
CAS:Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.Formula:C13H12ClN3O2Purity:98% - 99.50%Color and Shape:SolidMolecular weight:277.71Ref: TM-T7504
1mg65.00€5mg107.00€10mg169.00€25mg305.00€50mg527.00€100mg743.00€500mg1,510.00€1mL*10mM (DMSO)140.00€Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purity:100% - 99.97%Color and Shape:Yellow SolidMolecular weight:384.24Ref: TM-T2399
5mg52.00€10mg64.00€25mg80.00€50mg96.00€100mg144.00€200mg225.00€500mg373.00€1mL*10mM (DMSO)52.00€BI1543673
BI1543673 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It can diminish inflammatory responses in human lung tissue stimulated by TLR4 and TLR7/8. Additionally, BI1543673 reduces inflammatory signaling in a mouse lung inflammation model induced by LPS.Color and Shape:Odour SolidIrigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFormula:C18H16O8Purity:99.50% - 99.85%Color and Shape:SolidMolecular weight:360.31Phellodendrine
CAS:Phellodendrine may treat nephritis by blocking macrophage and T cell activity in glomeruli.Formula:C20H24NO4Purity:98.7% - 99.94%Color and Shape:SolidMolecular weight:342.41
