NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
Sort by
INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formula:C15H16N2OPurity:95.41%Color and Shape:SolidMolecular weight:240.3Ref: TM-T5209
2mg38.00€5mg56.00€10mg84.00€25mg120.00€50mg210.00€100mg313.00€200mg452.00€1mL*10mM (DMSO)58.00€TH023
TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.Formula:C22H21ClF2N4OColor and Shape:SolidMolecular weight:430.88SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formula:C131H234N36O31SPurity:99.86%Color and Shape:SolidMolecular weight:2841.55Asperulosidic acid
CAS:Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.Formula:C18H24O12Purity:99.47%Color and Shape:SolidMolecular weight:432.38SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Formula:C129H230N36O29S·XCF3COOHColor and Shape:SolidMolecular weight:2781.5 (free base)CLEFMA
CAS:CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formula:C23H17Cl2NO4Purity:98.17%Color and Shape:SolidMolecular weight:442.29Ref: TM-T9582
1mg87.00€5mg192.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)219.00€Tectochrysin
CAS:Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.Formula:C16H12O4Purity:99.26%Color and Shape:SolidMolecular weight:268.26RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Formula:C24H16N4O2S2Purity:98%Color and Shape:SolidMolecular weight:456.54IRAK4-IN-10
CAS:IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.Formula:C22H24N8Purity:99.76%Color and Shape:SolidMolecular weight:400.48Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Formula:C53H86O23Purity:98% - 99.83%Color and Shape:SolidMolecular weight:1091.24Fibrinogen
CAS:Fibrinogen is a heterodimeric protein that can be cleaved by thrombin.Color and Shape:SolidHesperidin methylchalcone
CAS:Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Formula:C29H36O15Purity:99.53%Color and Shape:Yellow PowderMolecular weight:624.59(Rac)-Benpyrine
CAS:(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Formula:C16H16N6OPurity:98.44%Color and Shape:SolidMolecular weight:308.34Ref: TM-T8692
1mg73.00€5mg124.00€10mg187.00€25mg376.00€50mg562.00€100mg802.00€500mg1,644.00€1mL*10mM (DMSO)137.00€(−)-N-Hydroxyapiosporamide
CAS:(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo.Formula:C24H31NO7Purity:98%Color and Shape:SolidMolecular weight:445.51Iron sucrose
CAS:Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.Formula:C18H24Fe2O24Purity:98%Color and Shape:SolidMolecular weight:736.1MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formula:C26H37ClN6O2Purity:98.19%Color and Shape:SolidMolecular weight:501.07ALPK1-IN-3
CAS:ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-inducedFormula:C20H16F2N4OSPurity:98%Color and Shape:SolidMolecular weight:398.43Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formula:C54H92O23Purity:99.12% - 99.76%Color and Shape:SolidMolecular weight:1109.29Eurycomalactone
CAS:Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.Formula:C19H24O6Purity:98.98% - 99.87%Color and Shape:SolidMolecular weight:348.39Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formula:C25H24O6Purity:98.68% - 99.8%Color and Shape:SolidMolecular weight:420.45Sodium Aescinate
CAS:Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.Formula:C54H83NaO23Purity:95.17%Color and Shape:SolidMolecular weight:1123.21Dehydrodiisoeugenol
CAS:Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Formula:C20H22O4Purity:99.97%Color and Shape:SolidMolecular weight:326.39Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Formula:C19H20O6Purity:99.6% - 99.71%Color and Shape:SolidMolecular weight:344.36EUK-134
CAS:EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formula:C18H18ClMnN2O4Purity:98.39%Color and Shape:SolidMolecular weight:416.74Ref: TM-T6495
10mg35.00€25mg66.00€50mg104.00€100mg160.00€200mg230.00€500mg378.00€1mL*10mM (DMSO)47.00€GSK-872
CAS:GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.Formula:C19H17N3O2S2Purity:99.3%Color and Shape:SolidMolecular weight:383.49Ref: TM-T4074
1mg38.00€5mg79.00€10mg119.00€25mg188.00€50mg321.00€100mg494.00€200mg705.00€1mL*10mM (DMSO)86.00€Anatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Formula:C22H28N2O14Purity:98%Color and Shape:SolidMolecular weight:544.46Necrostatin-34
CAS:Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying aFormula:C18H16N4O2S2Purity:98.66% - 98.80%Color and Shape:SolidMolecular weight:384.48Ref: TM-T9095
1mg52.00€5mg116.00€10mg170.00€25mg305.00€50mg442.00€100mg615.00€200mg832.00€1mL*10mM (DMSO)135.00€HOIPIN-1
CAS:HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formula:C17H13NaO4Purity:98.83%Color and Shape:SoildMolecular weight:304.27Mangiferin
CAS:Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formula:C19H18O11Purity:96.74% - 98.30%Color and Shape:Light Yellow PowderMolecular weight:422.34Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFormula:C24H21Cl2NO3Purity:98%Color and Shape:SolidMolecular weight:442.33CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formula:C28H28N2O6SColor and Shape:SolidMolecular weight:520.6GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formula:C22H20O8Color and Shape:SolidMolecular weight:412.39Oxaprozin
CAS:Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formula:C18H15NO3Purity:98.53%Color and Shape:SolidMolecular weight:293.32Rucaparib Phosphate
CAS:Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formula:C19H18FN3O·H3PO4Purity:99.1%Color and Shape:SolidMolecular weight:421.36Ref: TM-T6127
1mg38.00€2mg49.00€5mg79.00€10mg115.00€25mg188.00€50mg248.00€100mg393.00€200mg585.00€1mL*10mM (DMSO)79.00€Dehydroevodiamine
CAS:Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressantFormula:C19H15N3OPurity:99.54%Color and Shape:SolidMolecular weight:301.34GSK583
CAS:GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).Formula:C20H19FN4O2SPurity:98.68% - 99.06%Color and Shape:SolidMolecular weight:398.45Ref: TM-T3537
1mg50.00€2mg71.00€5mg116.00€10mg190.00€25mg319.00€50mg465.00€100mg690.00€500mg1,444.00€1mL*10mM (DMSO)116.00€Moslosooflavone
CAS:Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Formula:C17H14O5Purity:98% - 99.78%Color and Shape:SolidMolecular weight:298.29IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formula:C12H11N3O2SPurity:100%Color and Shape:SolidMolecular weight:261.3Ref: TM-T36524
1mg163.00€5mg395.00€10mg605.00€25mg938.00€50mg1,264.00€100mg1,700.00€200mg2,270.00€500µg111.00€Astilbin
CAS:Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Formula:C21H22O11Purity:97% - 99.76%Color and Shape:White PowderMolecular weight:450.39Ref: TM-T2794
5mg52.00€10mg77.00€25mg140.00€50mg224.00€100mg334.00€200mg477.00€500mg778.00€1mL*10mM (DMSO)51.00€Rucaparib monocamsylate
CAS:Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Formula:C29H34FN3O5SPurity:99.82%Color and Shape:SolidMolecular weight:555.66Ref: TM-T16807
5mg60.00€10mg96.00€25mg160.00€50mg235.00€100mg354.00€200mg522.00€1mL*10mM (DMSO)74.00€Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formula:C20H18O11Purity:97.02% - 99.94%Color and Shape:White PowderMolecular weight:434.35Ref: TM-T6S0117
1mg58.00€5mg97.00€10mg160.00€25mg283.00€50mg418.00€100mg615.00€200mg878.00€1mL*10mM (DMSO)111.00€Sinomenine hydrochloride
CAS:Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formula:C19H24ClNO4Purity:99.43%Color and Shape:SolidMolecular weight:365.851(R)-(-)-Ibuprofen
CAS:(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Formula:C13H18O2Purity:99.47%Color and Shape:SolidMolecular weight:206.28Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H26ClN3O4Color and Shape:SolidMolecular weight:431.91Kaempferol-3-O-glucorhamnoside
CAS:Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFormula:C27H30O15Purity:96.96% - 98.17%Color and Shape:SolidMolecular weight:594.5Ref: TM-T5S0089
1mg50.00€5mg97.00€10mg143.00€25mg226.00€50mg340.00€100mg495.00€200mg682.00€1mL*10mM (DMSO)129.00€Berbamine dihydrochloride
CAS:Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Formula:C37H42Cl2N2O6Purity:95% - 99.38%Color and Shape:SolidMolecular weight:681.65Dauricine
CAS:1.Formula:C38H44N2O6Purity:99.04% - 99.38%Color and Shape:White PowderMolecular weight:624.77JH-X-119-01
CAS:JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.Formula:C25H20N6O3Purity:97.1%Color and Shape:SolidMolecular weight:452.46Ref: TM-T9203
1mg66.00€2mg96.00€5mg144.00€10mg210.00€25mg376.00€50mg562.00€100mg780.00€1mL*10mM (DMSO)159.00€Diethylmaleate
CAS:Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.Formula:C8H12O4Purity:98%Color and Shape:Colourless LiquidMolecular weight:172.1818α-Glycyrrhetinic acid
CAS:18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Formula:C30H46O4Purity:98.54% - 99.68%Color and Shape:SolidMolecular weight:470.68Tenuigenin
CAS:Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.Formula:C30H45ClO6Purity:98.9% - 99.53%Color and Shape:SolidMolecular weight:537.13Ref: TM-T3907
2mg37.00€5mg52.00€10mg77.00€25mg111.00€50mg160.00€100mg227.00€200mg335.00€1mL*10mM (DMSO)66.00€RIPK1-IN-7
CAS:RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.Formula:C25H22F3N5O2Purity:98.02% - 98.18%Color and Shape:SolidMolecular weight:481.47Ref: TM-T12731
1mg92.00€5mg216.00€10mg329.00€25mg512.00€50mg707.00€100mg944.00€1mL*10mM (DMSO)233.00€Sciadopitysin
CAS:Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.Formula:C33H24O10Purity:98.14% - 99.17%Color and Shape:SolidMolecular weight:580.54Ref: TM-T5S2129
1mg52.00€5mg95.00€10mg162.00€25mg304.00€50mg455.00€100mg653.00€500mg1,349.00€1mL*10mM (DMSO)130.00€Sarsasapogenin
CAS:Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.Formula:C27H44O3Purity:90% - 99.73%Color and Shape:White Or Off-Withe PowderMolecular weight:416.64MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formula:C19H15ClN4O2Purity:98.92%Color and Shape:SolidMolecular weight:366.8Ref: TM-TQ0306
1mg49.00€2mg70.00€5mg96.00€10mg160.00€25mg329.00€50mg567.00€100mg777.00€1mL*10mM (DMSO)116.00€DRI-C21045
CAS:Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Formula:C32H24N2O7SPurity:98.10%Color and Shape:SolidMolecular weight:580.61IQ-1S free acid
CAS:IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formula:C15H9N3OPurity:97.92% - 99.05%Color and Shape:SolidMolecular weight:247.25Ref: TM-T3627
5mg47.00€10mg52.00€25mg96.00€50mg169.00€100mg304.00€200mg454.00€500mg733.00€1mL*10mM (DMSO)50.00€NF-κΒ activator 1
CAS:NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Formula:C16H11FN2O2SPurity:98.85%Color and Shape:SolidMolecular weight:314.33Ref: TM-T39965
1mg95.00€5mg202.00€10mg329.00€25mg560.00€50mg800.00€100mg1,103.00€500mg2,213.00€1mL*10mM (DMSO)224.00€Dehydrocostus Lactone
CAS:Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Formula:C15H18O2Purity:99.86% - 99.98%Color and Shape:SolidMolecular weight:230.3Theophylline monohydrate
CAS:Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormula:C7H8N4O2·H2OPurity:99.78%Color and Shape:SolidMolecular weight:198.18Chelidonic acid
CAS:Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.Formula:C7H4O6Purity:99.03%Color and Shape:SolidMolecular weight:184.1Cyclo(his-pro)
CAS:Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.Formula:C11H14N4O2Purity:99.87%Color and Shape:SolidMolecular weight:234.25Tripeptide-41
CAS:Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formula:C29H30N4O5Purity:98%Color and Shape:SolidMolecular weight:514.57Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.Formula:C20H21F3N4O4SPurity:98.48%Color and Shape:SolidMolecular weight:470.47Ref: TM-T37076
1mg43.00€5mg96.00€10mg135.00€25mg220.00€50mg323.00€100mg450.00€500mgTo inquire1mL*10mM (DMSO)96.00€NF-κB-IN-11
CAS:NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Formula:C19H18O5Purity:98%Color and Shape:SolidMolecular weight:326.34Kamebakaurin
CAS:Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Formula:C20H30O5Purity:98.05%Color and Shape:SolidMolecular weight:350.45NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).Formula:C19H18N3O2PSPurity:99.41%Color and Shape:SolidMolecular weight:383.4Prostratin
CAS:Prostratin is an orally active PKC activator,an NF-κB activator and activates HIV expression. Induces KRAS phosphorylation and inhibits tumor growth.Formula:C22H30O6Purity:98%Color and Shape:White To Off-White PowderMolecular weight:390.47Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormula:C21H18O11Purity:90.08% - 99.25%Color and Shape:Yellow PowderMolecular weight:446.36CAFESTOL
CAS:Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.Formula:C20H28O3Purity:97.06% - 99.08%Color and Shape:SolidMolecular weight:316.43NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Formula:C13H8F2INO2Purity:99.64%Color and Shape:SolidMolecular weight:375.11Cyclo(L-Pro-L-Val)
CAS:Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.Formula:C10H16N2O2Purity:98.18%Color and Shape:SolidMolecular weight:196.25CDDO-dhTFEA
CAS:CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formula:C33H45F3N2O3Purity:95.61% - 99.59%Color and Shape:SolidMolecular weight:574.72Ref: TM-T13604
1mg70.00€2mg92.00€5mg153.00€10mg255.00€25mg512.00€50mg738.00€100mg1,035.00€500mg2,062.00€1mL*10mM (DMSO)187.00€Rucaparib
CAS:Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Formula:C19H18FN3OPurity:98.37% - 99.80%Color and Shape:SolidMolecular weight:323.36Ref: TM-T4463
2mg48.00€5mg73.00€10mg115.00€25mg173.00€50mg235.00€100mg364.00€200mg540.00€500mg869.00€1mL*10mM (DMSO)81.00€SC75741
CAS:SC75741 is a potent P65 inhibitor with IC50 of 200 nMFormula:C29H23N7O2S2Purity:99.44% - 99.82%Color and Shape:SolidMolecular weight:565.67Edecesertib
CAS:Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.Formula:C22H22FN7O2Purity:98.84%Color and Shape:SolidMolecular weight:435.45ANTHRAQUINONE-2-CARBOXYLIC ACID
CAS:Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role ofFormula:C15H8O4Purity:99.08% - 99.83%Color and Shape:SolidMolecular weight:252.22Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purity:95.32% - 98.46%Color and Shape:SolidMolecular weight:505.56Muscone
CAS:Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Formula:C16H30OPurity:99.28%Color and Shape:Colourless Liquid LiquidMolecular weight:238.41TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formula:C27H37N7O2Purity:99.91%Color and Shape:SolidMolecular weight:491.63Zingerone
CAS:Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale with potent anti-inflammatory, antidiabetic and anti-tumor properties.Formula:C11H14O3Purity:99.38% - 99.85%Color and Shape:Clear Slightly Yellow LiquidMolecular weight:194.23PROTAC IRAK4 degrader-8
CAS:PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].Formula:C43H50ClF2N11O5Purity:98%Color and Shape:SolidMolecular weight:874.38WAY-169916
CAS:WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Formula:C17H13F3N2O2Purity:98.63% - 98.64%Color and Shape:SolidMolecular weight:334.29Ref: TM-T8981
2mg42.00€5mg64.00€10mg97.00€25mg197.00€50mg329.00€100mg475.00€200mg655.00€1mL*10mM (DMSO)94.00€Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formula:C23H17N3OS3Purity:98.02% - 98.31%Color and Shape:SolidMolecular weight:447.6Malachite green oxalate
CAS:Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Formula:C23H25N2·C2HO4C2H2O4Color and Shape:Dark Green Crystals With A Metallic LusterMolecular weight:463.51IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formula:C15H8ClF6NO2Purity:99.56% - 99.71%Color and Shape:SolidMolecular weight:383.67Ref: TM-T6141
2mg48.00€5mg66.00€10mg92.00€25mg163.00€50mg221.00€100mg310.00€500mg753.00€1mL*10mM (DMSO)69.00€RIP2 Kinase Inhibitor 3
CAS:RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.Formula:C19H24N4O3SPurity:98.28% - 98.35%Color and Shape:SolidMolecular weight:388.48Benzoyloxypaeoniflorin
CAS:Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Formula:C30H32O13Purity:97.64% - 98.7%Color and Shape:SolidMolecular weight:600.57Ref: TM-T4S1658
1mg127.00€5mg298.00€10mg432.00€25mg697.00€50mg938.00€100mg1,293.00€1mL*10mM (DMSO)378.00€GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53Ref: TM-T15558
1mg73.00€5mg153.00€10mg255.00€25mg535.00€50mg910.00€100mg1,216.00€1mL*10mM (DMSO)340.00€RIPK1-IN-16
CAS:RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formula:C20H19N5O2SPurity:98%Color and Shape:SolidMolecular weight:393.46IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formula:C22H25F3N4O3Purity:97.32%Color and Shape:SolidMolecular weight:450.45Asatone
CAS:Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formula:C24H32O8Purity:99.84% - 99.92%Color and Shape:SolidMolecular weight:448.51Ref: TM-T10383
1mg88.00€5mg202.00€10mg303.00€25mg509.00€50mg725.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)198.00€BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formula:C14H18ClN5Purity:99.13%Color and Shape:SolidMolecular weight:291.78Ref: TM-T8542
1mg40.00€2mg52.00€5mg87.00€10mg126.00€25mg225.00€50mg376.00€100mg563.00€1mL*10mM (DMSO)55.00€Velutin
CAS:Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well asFormula:C17H14O6Purity:99.69%Color and Shape:SolidMolecular weight:314.29AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Formula:C21H23N5O4SPurity:98.98% - 99.17%Color and Shape:SolidMolecular weight:441.5Ref: TM-T6771
1mg52.00€2mg70.00€5mg103.00€10mg160.00€25mg311.00€50mg502.00€100mg805.00€500mg1,605.00€1mL*10mM (DMSO)114.00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45Ref: TM-T9010
1mg40.00€5mg96.00€10mg135.00€25mg226.00€50mg320.00€100mg434.00€200mg602.00€1mL*10mM (DMSO)131.00€PROTAC IRAK4 degrader-12
CAS:PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Formula:C46H50ClF2N11O6Color and Shape:SolidMolecular weight:926.41BI-69A11
CAS:BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.Formula:C25H16ClN3O2Purity:96.97%Color and Shape:SolidMolecular weight:425.87Ref: TM-T25150
1mg46.00€2mg57.00€5mg82.00€10mg96.00€25mg180.00€50mg259.00€100mg369.00€1mL*10mM (DMSO)93.00€PROTAC IRAK4 ligand-4
CAS:PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.Formula:C24H26F2N6O3Color and Shape:SolidMolecular weight:484.5INF 195
CAS:INF 195 is an inflammasome NLRP3 inhibitor that can be used to study myocardial ischemia and myocardial infarction.Formula:C17H22ClNO3Purity:99.78%Color and Shape:SoildMolecular weight:323.81Stachydrine Hydrochloride
CAS:Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.Formula:C7H14ClNO2Purity:99.53% - 99.71%Color and Shape:Light Yellow PasteMolecular weight:179.64Vanillic Acid
CAS:Vanillic Acid (Acide vanillique) is used as a condiment in food, which used in wine. It is an intermediate in the production of vanillin from ferulic acid.Formula:C8H8O4Purity:99.82%Color and Shape:White Odourless Crystals Or PowderMolecular weight:168.15Indacaterol maleate
CAS:Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.Formula:C28H32N2O7Purity:99.03% - 99.67%Color and Shape:SolidMolecular weight:508.56Anti-inflammatory agent 51
CAS:Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.Formula:C22H22N6O6SPurity:99.46%Color and Shape:SoildMolecular weight:498.512-Hydroxychalcone
CAS:2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated. It inhibits invasion of breast cancer cells.Formula:C15H12O2Purity:99.60%Color and Shape:SolidMolecular weight:224.25Maslinic acid
CAS:Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.Formula:C30H48O4Purity:98.1% - 99.98%Color and Shape:SolidMolecular weight:472.7Guaiacol
CAS:Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.Formula:C7H8O2Purity:99.83%Color and Shape:Colourless To Pale Yellow Solid CrystallineMolecular weight:124.14ZB-R-55
CAS:ZB-R-55 is an oral and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.Formula:C25H23N5O3Purity:98.26%Color and Shape:SolidMolecular weight:441.48Sinomenine
CAS:Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.Formula:C19H23NO4Purity:99.02% - 99.89%Color and Shape:White PowderMolecular weight:329.39Karacoline
CAS:Karacolinem: natural compound, inhibits ECM breakdown in IDD through NF-κB pathway.Formula:C22H35NO4Purity:99.64% - 99.75%Color and Shape:SolidMolecular weight:377.52Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormula:C13H8O3Purity:99.45%Color and Shape:SolidMolecular weight:212.2Selnoflast
CAS:Selnoflast (RO-7486967) is an orally active, potent and selective NLRP3 inhibitor for the study of coronary arteries and ulcerative colitis.Formula:C20H29N3O3SPurity:100% - 99.82%Color and Shape:SolidMolecular weight:391.53Neferine
CAS:Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.Formula:C38H44N2O6Purity:98.81% - 99.18%Color and Shape:SolidMolecular weight:624.77anemarsaponin B
CAS:Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFormula:C45H74O18Purity:99.06% - 99.81%Color and Shape:SolidMolecular weight:903.06(S)-(+)-Ibuprofen
CAS:(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).Formula:C13H18O2Purity:99.51% - 99.86%Color and Shape:Colourless Crystalline SolidMolecular weight:206.28GSK2982772
CAS:GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.Formula:C20H19N5O3Purity:99.27% - 99.31%Color and Shape:SolidMolecular weight:377.4Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45HOMOPLANTAGININ
CAS:Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and showsFormula:C22H22O11Purity:97.63% - 99.66%Color and Shape:SolidMolecular weight:462.4Ref: TM-T4S0217
5mg50.00€10mg74.00€25mg140.00€50mg226.00€100mg324.00€200mg464.00€1mL*10mM (DMSO)52.00€Saikosaponin A
CAS:Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-Formula:C42H68O13Purity:99.57% - 99.88%Color and Shape:White PowderMolecular weight:780.98IR-Crizotinib
CAS:IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranialFormula:C53H57Cl2FIN7OPurity:98%Color and Shape:SolidMolecular weight:1024.88RIP1 kinase inhibitor 5
CAS:RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) inFormula:C13H17F2NO2Purity:98%Color and Shape:SolidMolecular weight:257.28NLRP3-IN-9
CAS:NLRP3-IN-9 (INF-4E) irreversibly inhibits NLRP3 ATPase, caspase-1, and prevents pyroptosis in THP-1 cells.Formula:C12H13ClO3Purity:98.51%Color and Shape:SolidMolecular weight:240.68NF-κB-IN-8
CAS:NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.Formula:C24H21N3O3Purity:98%Color and Shape:SolidMolecular weight:399.44Ginsenoside Rb3
CAS:Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity.Formula:C53H90O22Purity:98% - 99.98%Color and Shape:SolidMolecular weight:1079.27Aristolochic acid A
CAS:Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.Formula:C17H11NO7Purity:99.85% - 99.97%Color and Shape:Yellow PowderMolecular weight:341.27IRAK inhibitor 3
CAS:IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.Formula:C21H21N5O4SPurity:98.86%Color and Shape:SolidMolecular weight:439.493'-Sialyllactose sodium
CAS:3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.Formula:C23H38NNaO19Purity:100%Color and Shape:SolidMolecular weight:655.53GSK963
CAS:GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).Formula:C14H18N2OPurity:98.00%Color and Shape:SolidMolecular weight:230.31Ref: TM-T5054
1mg35.00€2mg50.00€5mg79.00€10mg119.00€25mg235.00€50mg378.00€100mg552.00€1mL*10mM (DMSO)87.00€Pyrrolidinedithiocarbamate ammonium
CAS:Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxideFormula:C5H12N2S2Purity:100% - ≥98%Color and Shape:Off-White To Pale Yellow CrystalsMolecular weight:164.29Myrcene
CAS:Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.Formula:C10H16Purity:75%Color and Shape:Colourless Slightly Amber Coloured LiquidMolecular weight:136.23IMD-biphenylC
CAS:IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.674-Octylphenol
CAS:4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.Formula:C14H22OColor and Shape:SolidMolecular weight:206.32Armepavine
CAS:Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.Formula:C19H23NO3Purity:95.00%Color and Shape:SolidMolecular weight:313.39Micheliolide
CAS:Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.Formula:C15H20O3Purity:98% - 99.37%Color and Shape:SolidMolecular weight:248.32Ref: TM-T5688
1mg47.00€5mg119.00€10mg187.00€25mg316.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)131.00€2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.Formula:C11H10N2OSPurity:99.48%Color and Shape:SolidMolecular weight:218.27Rubiadin-1-methyl ether
CAS:Rubiadin-1-methyl ether: a natural inhibitor of bone resorption, blocking NF-κB p65 phosphorylation and IκBα degradation.Formula:C16H12O4Purity:98.32%Color and Shape:SolidMolecular weight:268.26Saikosaponin D
CAS:Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Formula:C42H68O13Purity:98.34% - 99.73%Color and Shape:White PowderMolecular weight:780.98SZM679
SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.Formula:C27H18F5N3O5SPurity:98%Color and Shape:SolidMolecular weight:591.51IRAK4-IN-26
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%.Formula:C22H23N5O3Purity:98%Color and Shape:SolidMolecular weight:405.45Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formula:C17H13N3O3Purity:99.20% - 99.30%Color and Shape:SolidMolecular weight:307.31-Caffeoylquinic acid
CAS:1-Caffeoylquinic acid: a lignin precursor with anti-influenza, antioxidant properties, and moderates post-meal glucose release.Formula:C16H18O9Purity:98.77% - 99.16%Color and Shape:SolidMolecular weight:354.31Ref: TM-TN1051
1mg90.00€5mg243.00€10mg351.00€25mg548.00€50mg735.00€100mgTo inquire1mL*10mM (DMSO)225.00€ETHYL CAFFEATE
CAS:Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.Formula:C11H12O4Purity:97.79%Color and Shape:SolidMolecular weight:208.21AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Formula:C21H31N5O2Purity:98.81%Color and Shape:SolidMolecular weight:385.5Ref: TM-T14367
1mg87.00€5mg164.00€10mg259.00€25mg369.00€50mg520.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)178.00€(E/Z)-IT-603
CAS:(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor. IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding activity.Formula:C11H9BrN2O3SPurity:99.35%Color and Shape:SolidMolecular weight:329.17Ref: TM-T8799
1mg59.00€5mg126.00€10mg202.00€25mg406.00€50mg607.00€100mg845.00€500mg1,738.00€1mL*10mM (DMSO)140.00€Myrislignan
CAS:Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.Formula:C21H26O6Purity:98.77% - 99.41%Color and Shape:SolidMolecular weight:374.43Ref: TM-T4S1540
1mg47.00€5mg93.00€10mg144.00€25mg250.00€50mg406.00€100mg592.00€1mL*10mM (DMSO)107.00€CBL0137
CAS:CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM).Formula:C21H24N2O2Purity:99.57%Color and Shape:SolidMolecular weight:336.434-Aminosalicylic acid
CAS:4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.Formula:C7H7NO3Purity:97.07%Color and Shape:Minute Crystals From Alc SolidMolecular weight:153.14IRAK-4 protein kinase inhibitor 2
CAS:IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Formula:C14H10N4O3Purity:99.67%Color and Shape:SolidMolecular weight:282.25BMS986299
CAS:BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.Formula:C18H19N7OPurity:99.93% - 99.93%Color and Shape:SolidMolecular weight:349.39Esculentoside A
CAS:Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.Formula:C42H66O16Purity:98% - 99.85%Color and Shape:SolidMolecular weight:826.96Dendrophenol
CAS:Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Formula:C17H20O5Purity:98.2% - 98.96%Color and Shape:SolidMolecular weight:304.34Ref: TM-T3S1707
1mg104.00€2mg145.00€5mg227.00€10mg338.00€25mg558.00€50mg797.00€100mg1,074.00€1mL*10mM (DMSO)246.00€NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFormula:C26H30N2O4Purity:98%Color and Shape:SolidMolecular weight:434.53DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formula:C13H11NO5Purity:98%Color and Shape:SolidMolecular weight:261.23NLRP3-IN-13
CAS:NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.Formula:C19H15N3O3SPurity:98.82%Color and Shape:SolidMolecular weight:365.41E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:98.83%Color and Shape:SolidMolecular weight:378.46Ref: TM-T6823
1mg50.00€2mg72.00€5mg107.00€10mg167.00€25mg304.00€50mg500.00€100mg725.00€200mg1,017.00€500mg1,510.00€1mL*10mM (DMSO)88.00€Ginsenoside Rk3
CAS:Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Formula:C36H60O8Purity:99.33% - 99.88%Color and Shape:SolidMolecular weight:620.86Ref: TM-T6S1495
1mg85.00€5mg172.00€10mg255.00€25mg426.00€50mg630.00€100mg898.00€1mL*10mM (DMSO)283.00€IVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin.Formula:C69H90F3N13O24Purity:98%Color and Shape:SoildMolecular weight:1542.54Sauchinone
CAS:Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Formula:C20H20O6Purity:100%Color and Shape:SolidMolecular weight:356.37Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01GSK840
CAS:GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFormula:C21H23N3O3Purity:99.48%Color and Shape:SolidMolecular weight:365.43Flizasertib
CAS:Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.Formula:C15H14FN3OPurity:100% - 99.39%Color and Shape:SolidMolecular weight:271.29Adelmidrol
CAS:Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.Formula:C13H26N2O4Purity:99.35% - 99.73%Color and Shape:SolidMolecular weight:274.36Eudebeiolide B
CAS:Eudebeiolide B, isolated from Salvia plebeia R.Formula:C15H18O4Purity:98%Color and Shape:SolidMolecular weight:262.3Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurity:98.89% - 99.28%Color and Shape:SolidMolecular weight:265.25BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormula:C15H15NO2SPurity:99.73%Color and Shape:SolidMolecular weight:273.35Ref: TM-T8705
1mg52.00€5mg116.00€10mg178.00€25mg340.00€50mg520.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)107.00€BMS-066
CAS:BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formula:C19H21N7O2Purity:98%Color and Shape:SolidMolecular weight:379.42Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formula:C33H40O19Purity:98.78% - 99.13%Color and Shape:SolidMolecular weight:740.66IMD-biphenylB
CAS:IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.67Usnoflast
CAS:Usnoflast (ZYIL1) is an NLRP3 inhibitor, inhibiting NLRP3 inflammasome activation, used in neurological disease research.Formula:C21H29N3O3SPurity:98.79%Color and Shape:SolidMolecular weight:403.54AP-1/NF-κB activation inhibitor 1
CAS:AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basalFormula:C13H11F3N4O4Purity:100% - 99.74%Color and Shape:SolidMolecular weight:344.25Ref: TM-T9656
1mg73.00€2mg96.00€5mg160.00€10mg216.00€25mg354.00€50mg525.00€100mg730.00€500mg1,483.00€1mL*10mM (DMSO)170.00€Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Formula:C31H42N2O3Purity:100% - 98.69%Color and Shape:SolidMolecular weight:490.68Ref: TM-T15198
1mg99.00€2mg144.00€5mg235.00€10mg376.00€25mg677.00€50mg1,064.00€1mL*10mM (DMSO)254.00€HS271
CAS:HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).Formula:C21H24F3N5O2Purity:98.12%Color and Shape:SolidMolecular weight:435.44Ref: TM-T37082
1mg62.00€2mg89.00€5mg135.00€10mg212.00€25mg368.00€50mg510.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)149.00€5-Aminosalicylic Acid
CAS:5-ASA, an anti-inflammatory salicylate, treats inflammatory bowel disease, active part of sulphalazine.Formula:C7H7NO3Purity:98.88% - 99.98%Color and Shape:Purplish-Tan Solid PowderMolecular weight:153.14Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formula:C24H30O14Purity:100% - 99.57%Color and Shape:SolidMolecular weight:542.49Ref: TM-T4S2326
1mg96.00€5mg264.00€10mg415.00€25mg677.00€50mg935.00€100mg1,254.00€500mg2,527.00€1mL*10mM (DMSO)315.00€Isoquercetin
CAS:1.Formula:C21H20O12Purity:98.08% - 99.29%Color and Shape:SolidMolecular weight:464.38Ref: TM-T5S0754
5mg49.00€10mg65.00€25mg97.00€50mg153.00€100mg221.00€200mg329.00€1mL*10mM (DMSO)50.00€Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Formula:C26H30O13Purity:98.84% - 99.27%Color and Shape:SolidMolecular weight:550.51Tyloxapol
CAS:Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.Formula:C70H124O13Purity:polymer - polymerColor and Shape:Clear Light Yellow Viscous LiquidMolecular weight:137.18Ref: TM-T6S1371
1mg52.00€5mg97.00€10mg140.00€25mg274.00€50mg411.00€100mg597.00€500mg1,225.00€1mL*10mM (DMSO)105.00€Demethyleneberberine
CAS:Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFormula:C19H18NO4Purity:98.08% - 99.18%Color and Shape:SolidMolecular weight:324.35Theaflavin 3,3'-digallate
CAS:Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormula:C43H32O20Purity:98.71% - 99.86%Color and Shape:SolidMolecular weight:868.7Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formula:C25H25N5O4Color and Shape:SolidMolecular weight:459.50Eclitasertib
CAS:Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).Formula:C19H18N6O3Purity:99.82%Color and Shape:SolidMolecular weight:378.38Ref: TM-T9702
1mg106.00€2mg150.00€5mg227.00€10mg359.00€25mg652.00€50mg905.00€100mg1,293.00€1mL*10mM (DMSO)250.00€BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formula:C23H26IN7O2SPurity:98% - 99.57%Color and Shape:SolidMolecular weight:591.47Ref: TM-T1830
5mg59.00€10mg97.00€25mg210.00€50mg343.00€100mg513.00€200mg740.00€500mg1,121.00€1mL*10mM (DMSO)88.00€CL075
CAS:CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 toFormula:C13H13N3SPurity:99.25%Color and Shape:SolidMolecular weight:243.33Flaconitine
CAS:Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.Formula:C36H49NO12Purity:98% - 99.84%Color and Shape:SolidMolecular weight:687.77Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formula:C21H22O11Purity:97.53% - 98.63%Color and Shape:SolidMolecular weight:450.39Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purity:100% - 99.78%Color and Shape:White PowderMolecular weight:947.15B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Formula:C19H16ClN5OSPurity:99.74%Color and Shape:SolidMolecular weight:397.88Mitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Purity:98%Color and Shape:SolidRIPK1-IN-9
CAS:RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Formula:C26H25FN6O2Purity:98.7%Color and Shape:SolidMolecular weight:472.51Ref: TM-T63055
1mg205.00€5mg495.00€10mg677.00€25mg1,008.00€50mg1,349.00€100mg1,833.00€200mg2,452.00€1mL*10mM (DMSO)568.00€Gossypin
CAS:Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Formula:C21H20O13Purity:97.57% - 98.97%Color and Shape:SolidMolecular weight:480.38NLRP3-IN-10
CAS:NLRP3-IN-10 (ZVN26391) is a strong NLRP3 inhibitor, IC50 251.1 nM, that reduces IL-1β and ASC speck, hindering inflammasome activation.Formula:C17H14BrFO3Purity:99.63%Color and Shape:SolidMolecular weight:365.19Ref: TM-T61392
5mg47.00€10mg70.00€25mg126.00€50mg187.00€100mg311.00€200mg465.00€1mL*10mM (DMSO)65.00€2,4-Diamino-6-hydroxypyrimidine
CAS:2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFormula:C4H6N4OPurity:99.82%Color and Shape:White Solid CrystalsMolecular weight:126.12NLRP3-IN-11
CAS:NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.Formula:C17H17ClN4O2Purity:100%Color and Shape:SolidMolecular weight:344.8GSK2983559 active metabolite
CAS:GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.Formula:C21H22N4O4S2Purity:97.07% - 98.48%Color and Shape:SolidMolecular weight:458.55Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64
