NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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NLRP3 agonist 1
CAS:Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.Formula:C15H16N6Purity:99.01%Color and Shape:SolidMolecular weight:280.33Salicortin
CAS:Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.Formula:C20H24O10Purity:98%Color and Shape:SolidMolecular weight:424.40GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Formula:C28H30N4O3Purity:99.32%Color and Shape:SolidMolecular weight:470.56BEC hydrochloride
CAS:BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.Formula:C5H12BNO4S·ClHPurity:98.65% - 99.28%Color and Shape:SolidMolecular weight:229.49Ref: TM-T6779
1mg39.00€2mg49.00€5mg88.00€10mg153.00€25mg283.00€50mg535.00€100mg747.00€1mL*10mM (DMSO)88.00€Sanggenon A
CAS:Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and itFormula:C25H24O7Purity:98%Color and Shape:SolidMolecular weight:436.45Narlumosbart
CAS:Narlumosbart (JMT103) is an IgG4κ monoclonal antibody that selectively binds to the receptor activator of nuclear factor-κB ligand (RANKL)[1].Purity:98%Color and Shape:LiquidRIPK1-IN-19
CAS:RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.Formula:C28H25FN6O2Purity:98.81%Color and Shape:SolidMolecular weight:496.54PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formula:C22H24N4O3SPurity:98.09% - 98.13%Color and Shape:SolidMolecular weight:424.52Ref: TM-T12493
1mg86.00€5mg170.00€10mg274.00€25mg520.00€50mg750.00€100mg1,026.00€200mg1,388.00€1mL*10mM (DMSO)188.00€IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFormula:C35H33N5O2Purity:98%Color and Shape:SolidMolecular weight:555.67(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formula:C27H30F3N9OPurity:98%Color and Shape:SolidMolecular weight:553.58DCZ0415
CAS:DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Formula:C23H20N2O2Purity:99.34%Color and Shape:SolidMolecular weight:356.42Ref: TM-T10981
1mg52.00€5mg116.00€10mg188.00€25mg354.00€50mg588.00€100mg873.00€1mL*10mM (DMSO)126.00€Kukoamine A
CAS:Kukoamine A: anticancer, cytoprotective, antioxidant, anti-inflammatory, inhibits trypanothione reductase (mixed inhibitor, Ki=1.8µM).Formula:C28H42N4O6Purity:97.45% - 99.28%Color and Shape:SolidMolecular weight:530.66Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formula:C42H70O12Purity:99.13%Color and Shape:SolidMolecular weight:767IRAK4-IN-1
CAS:IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.Formula:C19H23N5OPurity:98.18% - 99.74%Color and Shape:SolidMolecular weight:337.42Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.Formula:C15H24O5Purity:99.41% - 99.72%Color and Shape:White SolidMolecular weight:284.35Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16IRAK4-IN-7
CAS:IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.Formula:C21H19N7O3Purity:99.50%Color and Shape:SolidMolecular weight:417.42Ref: TM-T5354
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg210.00€50mg354.00€100mg528.00€1mL*10mM (DMSO)87.00€Ginsenoside Rg1
CAS:Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng).Formula:C42H72O14Purity:99% - 99.74%Color and Shape:White Crystalline PowderMolecular weight:801.01Vamorolone
CAS:Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.Formula:C22H28O4Purity:99.54%Color and Shape:SolidMolecular weight:356.46Ref: TM-T17217
1mg37.00€2mg52.00€5mg79.00€10mg111.00€25mg188.00€50mg298.00€100mg444.00€200mg640.00€1mL*10mM (DMSO)87.00€Mollugin
CAS:Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Formula:C17H16O4Purity:98.31% - ≥95%Color and Shape:SolidMolecular weight:284.31Supercinnamaldehyde
CAS:Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ionFormula:C12H11NO2Purity:98.89%Color and Shape:SolidMolecular weight:201.22Stachydrine
CAS:Stachydrine, found in leonurus herb, aids blood flow, blocks NF-κB pathway, and indicates citrus intake.Formula:C7H13NO2Purity:≥95%Color and Shape:SolidMolecular weight:143.18OPHIOPOGONIN D
CAS:Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.Formula:C44H70O16Purity:99.46% - ≥95%Color and Shape:SolidMolecular weight:855.02Ergolide
CAS:Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Formula:C17H22O5Purity:99.64%Color and Shape:SolidMolecular weight:306.35Ref: TM-T13686
1mg74.00€5mg146.00€10mg243.00€25mg394.00€50mg548.00€100mg735.00€1mL*10mM (DMSO)170.00€Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purity:96.59% - 98.91%Color and Shape:SolidMolecular weight:383.82IRAK inhibitor 1
CAS:IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).Formula:C17H19N5Purity:100% - 97.78%Color and Shape:SolidMolecular weight:293.37Ref: TM-T5094
1mg95.00€2mg125.00€5mg202.00€10mg283.00€25mg472.00€50mg687.00€100mg938.00€1mL*10mM (DMSO)135.00€Erdosteine
CAS:Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.Formula:C8H11NO4S2Purity:99.43% - 99.94%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:249.31CTP-NBD
CAS:CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].Formula:C121H194N46O32Purity:98%Color and Shape:SolidMolecular weight:2805.12Phorbol 12-myristate 13-acetate
CAS:Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Formula:C36H56O8Purity:100% - 99.5%Color and Shape:White To Off-White SolidMolecular weight:616.83Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51Muramyl dipeptide
CAS:MDP is a synthetic peptide promoting bone formation by modulating osteoclasts, osteoblasts, and Runx2 expression via MAPK pathways.Formula:C19H32N4O11Purity:100%Color and Shape:SolidMolecular weight:492.48Ref: TM-T16159
1mg88.00€5mg178.00€10mg279.00€25mg545.00€50mg777.00€100mg1,064.00€200mg1,415.00€1mL*10mM (DMSO)188.00€Bay 11-7085
CAS:Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Formula:C13H15NO2SPurity:99.76% - 99.83%Color and Shape:White SolidMolecular weight:249.33Ref: TM-T1934
2mg35.00€5mg50.00€10mg66.00€25mg85.00€50mg124.00€100mg197.00€200mg255.00€1mL*10mM (DMSO)62.00€Andrographolide
CAS:Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potentialFormula:C20H30O5Purity:100% - 99.97%Color and Shape:PowderMolecular weight:350.45Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Formula:C21H28BN3O5Purity:95.52% - 99.46%Color and Shape:SolidMolecular weight:413.28Ref: TM-T6027
1mg46.00€5mg96.00€10mg140.00€25mg274.00€50mg439.00€100mg660.00€200mg917.00€1mL*10mM (DMSO)95.00€IRAK4-IN-4
CAS:IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4)Formula:C22H16N2O2Purity:99.52%Color and Shape:SolidMolecular weight:340.37Ref: TM-T11673
1mg64.00€5mg145.00€10mg212.00€25mg378.00€50mg567.00€100mg815.00€200mg1,093.00€1mL*10mM (DMSO)160.00€Demethyleneberberine chloride
CAS:Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Formula:C19H18ClNO4Purity:98%Color and Shape:SolidMolecular weight:359.8RIPK1-IN-4
CAS:RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50sFormula:C23H23N5O2Purity:99.66%Color and Shape:SolidMolecular weight:401.46DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Formula:C17H27NO3Purity:100.00%Color and Shape:SolidMolecular weight:293.4Triptolide
CAS:Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.Formula:C20H24O6Purity:97.19% - 99.97%Color and Shape:White To Off-White SolidMolecular weight:360.4Ref: TM-T2179
1mg44.00€2mg58.00€5mg96.00€10mg137.00€25mg310.00€50mg462.00€100mg553.00€1mL*10mM (DMSO)85.00€Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Formula:C27H45NO2Purity:98.38% - 99.98%Color and Shape:SolidMolecular weight:415.65EN450
CAS:EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.Formula:C11H13ClN2O3SPurity:99.72%Color and Shape:SoildMolecular weight:288.75Ref: TM-T77525
1mg47.00€5mg87.00€10mg144.00€25mg283.00€50mg432.00€100mg628.00€500mg1,301.00€1mL*10mM (DMSO)97.00€Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82Anti-inflammatory agent 60
Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-cateninPurity:98%Color and Shape:Odour SolidGSK872 HCl(1346546-69-7 free base)
CAS:GSK872 HCl(1346546-69-7 free base) (GSK2399872A) is an effective and specific RIP3 kinase inhibitor.Formula:C19H18ClN3O2S2Purity:99%Color and Shape:SolidMolecular weight:419.94Pristimerin
CAS:Pristimerin has anticancer properties, counters hypoxia-induced cancer spread, and reduces inflammation by inhibiting ROS/IKK/NF-κB pathways.Formula:C30H40O4Purity:99.43% - 99.59%Color and Shape:SolidMolecular weight:464.64(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormula:C22H23NOPurity:98.55%Color and Shape:SolidMolecular weight:317.42Ref: TM-T11139
1mg80.00€5mg155.00€10mg283.00€25mg452.00€50mg638.00€100mg848.00€200mg1,121.00€1mL*10mM (DMSO)170.00€RIP1 kinase inhibitor 6
CAS:RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1Formula:C19H18F2N2O3Purity:98%Color and Shape:SolidMolecular weight:360.35TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formula:C26H27N5O3Purity:98.89%Color and Shape:SolidMolecular weight:457.52Ref: TM-T15559
1mg92.00€5mg188.00€10mg305.00€25mg487.00€50mg660.00€100mg847.00€1mL*10mM (DMSO)188.00€TAK-243
CAS:TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM).Formula:C19H20F3N5O5S2Purity:98.09% - 98.93%Color and Shape:SolidMolecular weight:519.52Ref: TM-T16974
1mg48.00€2mg64.00€5mg96.00€10mg150.00€25mg268.00€50mg459.00€100mg658.00€1mL*10mM (DMSO)107.00€SBI-0640726
CAS:SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.Formula:C23H15ClN2O2Color and Shape:SolidMolecular weight:386.83
