NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formula:C19H16ClN3O3SPurity:98.07%Color and Shape:SolidMolecular weight:401.87OT-551 HCl
CAS:OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macularFormula:C13H24ClNO3Purity:99.71%Color and Shape:SolidMolecular weight:277.79Ref: TM-T28273L
1mg115.00€5mg245.00€10mg363.00€25mg562.00€50mg802.00€100mg1,111.00€200mg1,491.00€1mL*10mM (DMSO)295.00€Theophylline
CAS:Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFormula:C7H8N4O2Purity:99.47% - 99.97%Color and Shape:White Solid PowderMolecular weight:180.16HOIPIN-8 sodium
CAS:HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formula:C23H15F2N4NaO3Purity:97.34%Color and Shape:SolidMolecular weight:456.38BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Formula:C10H7NO3Purity:96.48% - 97.00%Color and Shape:Yellow Crystalline PowderMolecular weight:189.17Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formula:C30H48O3Purity:99.12% - 99.7%Color and Shape:White Crystalline PowderMolecular weight:456.7Anti-inflammatory agent 50
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, andFormula:C40H55N3O6Purity:98%Color and Shape:SolidMolecular weight:673.88Caffeic Acid Phenethyl Ester
CAS:CAPE, in propolis, blocks NF-kappa B, suppresses p70S6K/Akt pathways, and inhibits PDGF, aiding in cancer protection and immune modulation.Formula:C17H16O4Purity:99.18% - 99.35%Color and Shape:Less Transparent Liquid Colorless Transparent LiquidMolecular weight:284.31Specnuezhenide
CAS:Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling.Cost-effective and quality-assured.Formula:C31H42O17Purity:98% - 99.12%Color and Shape:SolidMolecular weight:686.66Ref: TM-T3803
2mg38.00€5mg52.00€10mg88.00€25mg164.00€50mg233.00€100mg344.00€500mg830.00€1mL*10mM (DMSO)82.00€Damascenone
CAS:Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.Formula:C13H18OPurity:98.03%Color and Shape:Colorless LiquidMolecular weight:190.28NP3-146
CAS:NP3-146 (NLRP3-IN-5) is an inflammasome NLRP3 inhibitor with potential anti-inflammatory activity for the study of autoimmune diseases.Formula:C20H27ClN2O5SPurity:99.21%Color and Shape:SolidMolecular weight:442.96RIPK2-IN-5
CAS:RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysfunctions.Formula:C21H14N4SPurity:98.85%Color and Shape:SoildMolecular weight:354.43Sappanone A
CAS:Sappanone A is a high isoflavanone with anti-inflammatory properties.Sappanone A reduces allergic airway inflammation in ovalbumin-induced asthma.Formula:C16H12O5Purity:97.48% - 99.18%Color and Shape:SolidMolecular weight:284.26Pinocembrin
CAS:Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.Formula:C15H12O4Purity:100% - 99.61%Color and Shape:SolidMolecular weight:256.25NF-κB/MAPK-IN-1
CAS:NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).Formula:C27H27NO7Purity:97.03%Color and Shape:SolidMolecular weight:477.51Ref: TM-T63119
1mg47.00€2mg60.00€5mg87.00€10mg154.00€25mg329.00€50mg492.00€100mg710.00€1mL*10mM (DMSO)93.00€CBL0137 hydrochloride
CAS:CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB.Cost-effective and quality-assured.Formula:C21H25ClN2O2Purity:98.59% - 99.35%Color and Shape:SolidMolecular weight:372.88Nimbolide
CAS:Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Formula:C27H30O7Purity:95.84% - 99.4%Color and Shape:SolidMolecular weight:466.52Ref: TM-T16324
1mg88.00€5mg216.00€10mg376.00€25mg810.00€50mg1,074.00€100mg1,454.00€200mg1,882.00€1mL*10mM (DMSO)235.00€IRAK-1-4 Inhibitor I
CAS:IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.Formula:C20H21N5O4Purity:100% - 99.89%Color and Shape:SolidMolecular weight:395.41Ref: TM-T2457
1mg44.00€5mg79.00€10mg110.00€25mg224.00€50mg376.00€100mg540.00€500mg1,130.00€1mL*10mM (DMSO)79.00€Stipuleanoside R2
CAS:Stipuleanoside R2 is a triterpenoid saponin that inhibits NF-κB activation and has potential applications in inflammation, immunology, and cancer research.Formula:C53H84O23Purity:98%Color and Shape:SolidMolecular weight:1089.22Esculentoside H
CAS:Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Formula:C48H76O21Purity:98.04% - 99.3%Color and Shape:SolidMolecular weight:989.1Sootepin D
CAS:Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.Formula:C31H48O4Purity:98%Color and Shape:SolidMolecular weight:484.71IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Formula:C15H8BrF6NO2Purity:99.51%Color and Shape:SolidMolecular weight:428.12Sulindac
CAS:Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Formula:C20H17FO3SPurity:99.09% - 99.15%Color and Shape:Yellow SolidMolecular weight:356.41Goshonoside F5
CAS:Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.Formula:C32H54O13Purity:98%Color and Shape:SolidMolecular weight:646.771CID-2858522
CAS:CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).Formula:C28H39N3O3Purity:96.11%Color and Shape:SolidMolecular weight:465.63Kuromanin chloride
CAS:Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transductionFormula:C21H21ClO11Purity:97.27% - 98.69%Color and Shape:SolidMolecular weight:484.84Ref: TM-T3406
1mg35.00€2mg50.00€5mg82.00€10mg110.00€25mg207.00€50mg306.00€100mg459.00€1mL*10mM (DMSO)88.00€IRAK4-IN-27
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.Formula:C23H22N6O3Purity:98%Color and Shape:SolidMolecular weight:430.46Cantleyoside
CAS:Cantleyoside, a natural cyclic enol ether terpene glycoside from Pterocephalus hookeri, can activate of the AMPK/Sirt1/NF-κB signaling pathway.Formula:C33H46O19Purity:99.85%Color and Shape:SolidMolecular weight:746.71TNFα activity modulator 3
CAS:TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.Formula:C27H24F2N6O2Color and Shape:SolidMolecular weight:502.52BAL-0028
CAS:BAL-0028 is a potent inhibitor of NLRP3 activation (IC50: 25 nM) with anti-inflammatory activity for cancer research.Formula:C24H22FN3O2Purity:99.16%Color and Shape:SoildMolecular weight:403.45Physalin O
CAS:Physalin O has anti-inflammatory properties, binds with GSH, and inhibits NO production.Formula:C28H32O10Purity:98%Color and Shape:SolidMolecular weight:528.554JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Formula:C17H13NaO4Purity:95.08%Color and Shape:SolidMolecular weight:304.27Parthenolide
CAS:Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB and HDAC1 inhibitor with anti-inflammatory effect. Cost-effective and quality-assured.Formula:C15H20O3Purity:99.10% - 99.46%Color and Shape:White To Pale Yellow Crystalline PowderMolecular weight:248.32GSK547
CAS:GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.Formula:C20H18F2N6OPurity:99.17%Color and Shape:SolidMolecular weight:396.39Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formula:C13H14N2O4S2Purity:98%Color and Shape:SolidMolecular weight:326.39NLRP3-IN-51
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.Color and Shape:Odour SolidHS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Formula:C17H16N4O3Purity:97.34%Color and Shape:SolidMolecular weight:324.33RIP1 kinase inhibitor 4
CAS:RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].Formula:C23H23N5Purity:98%Color and Shape:SolidMolecular weight:369.46CHPG sodium salt
CAS:CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways.Formula:C8H7ClNNaO3Purity:100%Color and Shape:SolidMolecular weight:223.59IRAK4-IN-8
CAS:IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.Formula:C23H23F2N7O2SPurity:99.39%Color and Shape:SolidMolecular weight:499.54Ref: TM-T63388
1mg825.00€2mg1,130.00€5mg1,681.00€10mg2,270.00€25mg3,372.00€50mg4,541.00€100mg6,146.00€Rhynchophylline
CAS:Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.Formula:C22H28N2O4Purity:99.44%Color and Shape:Red Brown Or White Fine PowderMolecular weight:384.47Indole-3-carbinol
CAS:Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFormula:C9H9NOPurity:100% - 97.06%Color and Shape:SolidMolecular weight:147.17Coronalolic acid
CAS:Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.Formula:C30H46O4Purity:98%Color and Shape:SolidMolecular weight:470.681-Isomangostin
CAS:1-Isomangostin has cytotoxic and anticomplementary activities.Formula:C24H26O6Purity:99.71%Color and Shape:SolidMolecular weight:410.462,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formula:C8H8O3Purity:99.75%Color and Shape:Yellow PowderMolecular weight:152.15NF-κB-IN-12
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].Formula:C30H26N6O5SPurity:98%Color and Shape:SolidMolecular weight:582.63Zimlovisertib
CAS:Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).Formula:C18H20FN3O4Purity:98.21%Color and Shape:SolidMolecular weight:361.37Ref: TM-TQ0167
1mg35.00€5mg67.00€10mg115.00€25mg224.00€50mg404.00€100mg655.00€200mg910.00€1mL*10mM (DMSO)73.00€IRAK4-IN-25
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatoryFormula:C23H25N5O4Purity:98%Color and Shape:SolidMolecular weight:435.48JC124
CAS:JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.Formula:C17H19ClN2O4SPurity:98.54%Color and Shape:SolidMolecular weight:382.86Ref: TM-T25548
1mg64.00€5mg145.00€10mg226.00€25mg379.00€50mg538.00€100mg730.00€200mg938.00€1mL*10mM (DMSO)160.00€RIPK3-IN-4
CAS:RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage.Formula:C24H18BrFN4O3SPurity:98%Color and Shape:SolidMolecular weight:541.39
