NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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JSH-23
CAS:JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.Formula:C16H20N2Purity:98.03% - 99.67%Color and Shape:SolidMolecular weight:240.34Ref: TM-T1930
1mg43.00€2mg57.00€5mg93.00€10mg119.00€25mg187.00€50mg283.00€100mg430.00€1mL*10mM (DMSO)93.00€Quinoclamine
CAS:Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.Formula:C10H6ClNO2Purity:99.13% - 99.28%Color and Shape:Orange PowderMolecular weight:207.617,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Formula:C15H10O4Purity:99.39% - 99.6%Color and Shape:SolidMolecular weight:254.24Emlenoflast sodium
CAS:Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome,Formula:C19H24N4NaO3SColor and Shape:SolidMolecular weight:411.47SjDX5-271
CAS:SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.Formula:C137H215N47O49SColor and Shape:SolidMolecular weight:3336.52NF-κΒ activator 2
CAS:NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.Formula:C16H11FN2O3Purity:99.32%Color and Shape:SolidMolecular weight:298.27Ref: TM-T39924
1mg94.00€2mg136.00€5mg226.00€10mg335.00€25mg538.00€50mg730.00€100mg938.00€1mL*10mM (DMSO)249.00€HS-1371
CAS:HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.Formula:C24H24N4OPurity:98%Color and Shape:SolidMolecular weight:384.47Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formula:C6H9NOS2Purity:98.01% - 99.19%Color and Shape:Slightly Yellowish LiquidMolecular weight:175.27Ref: TM-TL0016
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg227.00€50mg338.00€100mg500.00€1mL*10mM (DMSO)69.00€Ac2-26 acetate
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1).Formula:C141H210N32O44SPurity:98%Color and Shape:SolidMolecular weight:3089.43CORM-3
CAS:CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.Formula:C5H4ClNO5RuPurity:98%Color and Shape:SolidMolecular weight:294.61NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormula:C31H30O8Purity:99.03%Color and Shape:SolidMolecular weight:530.57Ref: TM-T9105
1mg166.00€5mg341.00€10mg550.00€25mg898.00€50mg1,216.00€100mg1,644.00€1mL*10mM (DMSO)398.00€Indacaterol
CAS:Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.Formula:C24H28N2O3Purity:100.00% - 99.63%Color and Shape:SolidMolecular weight:392.49Sulfuretin
CAS:Sulfuretin protects HepG2 cells from oxidative damage by scavenging ROS and activating HO-1 via Nrf2/ARE and JNK/ERK pathways.Formula:C15H10O5Purity:100% - 98.91%Color and Shape:SolidMolecular weight:270.24WITHAFERIN A
CAS:WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/Formula:C28H38O6Purity:97.41% - 99.83%Color and Shape:SolidMolecular weight:470.6Ref: TM-T5687
1mg85.00€5mg265.00€10mg393.00€25mg653.00€50mg929.00€100mg1,254.00€500mg2,517.00€1mL*10mM (DMSO)304.00€IRAK4-IN-28
CAS:IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.Formula:C27H31N9O3Purity:98%Color and Shape:SolidMolecular weight:529.59Isonardosinone
CAS:Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities.Formula:C15H22O3Purity:98%Color and Shape:SolidMolecular weight:250.33GSK8612
CAS:GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Formula:C17H17BrF3N7O2SPurity:99.46% - ≥98%Color and Shape:SolidMolecular weight:520.33Ref: TM-T5540
1mg47.00€2mg59.00€5mg92.00€10mg131.00€25mg215.00€50mg378.00€100mg567.00€1mL*10mM (DMSO)96.00€Ginsenoside Rg2
CAS:Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.Formula:C42H72O13Purity:99.5% - 99.77%Color and Shape:SolidMolecular weight:785.01Ref: TM-T2873
2mg37.00€5mg52.00€10mg88.00€25mg131.00€50mg188.00€100mg279.00€500mg658.00€1mL*10mM (DMSO)87.00€Pratensein
CAS:Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Formula:C16H12O6Purity:99.72%Color and Shape:SolidMolecular weight:300.26γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formula:C28H42O2Purity:97.27% - 98.13%Color and Shape:SolidMolecular weight:410.63Ref: TM-T19768
1mg47.00€2mg62.00€5mg92.00€10mg144.00€25mg235.00€50mg350.00€100mg515.00€200mg743.00€1mL*10mM (DMSO)97.00€Tyrosol
CAS:Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present mostFormula:C8H10O2Purity:100% - 99.28%Color and Shape:SolidMolecular weight:138.16Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Formula:C40H52O4Purity:95.1% - 99.79%Color and Shape:Needles From Acetone/Light Petroleum SolidMolecular weight:596.84TRAF-STOP inhibitor 6877002
CAS:TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Formula:C17H17NOPurity:99.65%Color and Shape:SolidMolecular weight:251.32Handelin
CAS:Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.Formula:C32H40O8Purity:99.02%Color and Shape:SolidMolecular weight:552.66RIPK2-IN-3
CAS:RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.Formula:C25H22N4O2Purity:99.57%Color and Shape:SolidMolecular weight:410.47GSK2983559 free acid
CAS:GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.Formula:C21H23N4O7PS2Purity:97.87% - 98.61%Color and Shape:SolidMolecular weight:538.53Narasin (sodium salt)
CAS:Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells andFormula:C43H71NaO11Purity:98%Color and Shape:SolidMolecular weight:787.01Oditrasertib
CAS:Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.Formula:C14H15F2N3O2Purity:98.65% - 99.65%Color and Shape:SolidMolecular weight:295.28Naringin dihydrochalcone
CAS:Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Formula:C27H34O14Purity:99.07% - 99.16%Color and Shape:Solid PowderMolecular weight:582.55Isodeoxyelephantopin
CAS:Isodeoxyelephantopin can inhibit the growth of various tumor cells.Formula:C19H20O6Purity:99.88%Color and Shape:SolidMolecular weight:344.36NIK SMI1
CAS:NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Formula:C20H19N3O4Purity:99.04% - 99.99%Color and Shape:SolidMolecular weight:365.38Ref: TM-T16290
1mg87.00€5mg183.00€10mg296.00€25mg593.00€50mg932.00€100mg1,501.00€200mg2,052.00€1mL*10mM (DMSO)432.00€NDMC101
CAS:NDMC101 suppresses dipeptidyl peptidase-IV, NFATc1, and NF-κB in human T cells, modulating immunity.Formula:C13H9ClFNO2Purity:99.89%Color and Shape:SolidMolecular weight:265.67MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formula:C26H36N6O2Purity:99.25% - 99.79%Color and Shape:SolidMolecular weight:464.6GSK481
CAS:GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.Formula:C21H19N3O4Purity:98.97%Color and Shape:SolidMolecular weight:377.39COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Color and Shape:Odour SolidCOX-2-IN-32
CAS:COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.Formula:C25H24O6Purity:98%Color and Shape:SolidMolecular weight:420.45Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formula:C5H6N2OSPurity:100% - 99.89%Color and Shape:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Molecular weight:142.18α-Lipoic Acid
CAS:α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Formula:C8H14O2S2Purity:98.39% - 99.73%Color and Shape:Forms Yellowish Flakes Light Yellow To Yellow PowderMolecular weight:206.33Shikonin
CAS:Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.Formula:C16H16O5Purity:98.13% - 99.9%Color and Shape:SolidMolecular weight:288.3Ref: TM-T1125
5mg34.00€10mg52.00€25mg87.00€50mg140.00€100mg215.00€200mg319.00€500mg533.00€1mL*10mM (DMSO)52.00€20(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purity:100% - 99.93%Color and Shape:SolidMolecular weight:785.01UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Formula:C18H17N3OPurity:99.48%Color and Shape:SolidMolecular weight:291.35Ref: TM-T88314
2mg38.00€5mg57.00€10mg92.00€25mg166.00€50mg254.00€100mg389.00€200mg566.00€1mL*10mM (DMSO)63.00€ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Formula:C32H22O10Purity:98% - 99.72%Color and Shape:SolidMolecular weight:566.51Denosumab
CAS:Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligandFormula:C6404H9912N1724O2004S50Purity:98.4% (SEC-HPLC) - 99.90%Color and Shape:LiquidMolecular weight:144.71 kDaTrovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.12%Color and Shape:SolidMolecular weight:512.46Selinidin
CAS:Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.Formula:C19H20O5Purity:98%Color and Shape:SolidMolecular weight:328.364Biricodar dicitrate
CAS:Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.Formula:C46H57N3O21Purity:98.67% - 99.34%Color and Shape:SolidMolecular weight:987.95Ginsenoside Rg6
CAS:Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cellsFormula:C42H70O12Purity:≥98%Color and Shape:SolidMolecular weight:767Obtusifolin
CAS:Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.Formula:C16H12O5Purity:100% - 99.79%Color and Shape:SolidMolecular weight:284.26Ref: TM-T4S0969
1mg70.00€5mg187.00€10mg279.00€25mg472.00€50mg658.00€100mg933.00€1mL*10mM (DMSO)187.00€Molsidomine
CAS:Molsidomine, an oral vasodilator, turns into linsidomine in the liver, releasing NO for prolonged effects.Formula:C9H14N4O4Purity:100% - 99.98%Color and Shape:Colorless Or White Crystalline PowderMolecular weight:242.23Articaine hydrochloride
CAS:Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Formula:C13H21ClN2O3SPurity:99.76%Color and Shape:White Crystalline PowderMolecular weight:320.84
