NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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6‴-Feruloylspinosin
CAS:6‴-Feruloylspinosin (6'''-Feruloylspinosin) may possess anti-inflammatory activity.Formula:C38H40O18Purity:98.69% - 99.91%Color and Shape:SolidMolecular weight:784.71Praeruptorin A
CAS:Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulinFormula:C21H22O7Purity:99.63% - 99.65%Color and Shape:SolidMolecular weight:386.4ADS032
CAS:ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity for the study of respiratory inflammation or infection.Formula:C22H29NO4SPurity:99.33%Color and Shape:SolidMolecular weight:403.54MCC950
CAS:CP-456773 (MCC950) inhibits NLRP3 inflammasome, prevents IL-1β secretion, and reduces multiple sclerosis model severity.Formula:C20H24N2O5SPurity:97%Color and Shape:SolidMolecular weight:404.48Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Formula:C27H30O14Purity:98.11% - 98.87%Color and Shape:SolidMolecular weight:578.52Necroptosis-IN-1
CAS:Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.Formula:C12H10ClN3O2Purity:99.60% - 99.73%Color and Shape:SolidMolecular weight:263.68Ref: TM-T9305
1mg64.00€5mg117.00€10mg187.00€25mg319.00€50mg449.00€100mg638.00€200mg840.00€1mL*10mM (DMSO)149.00€Neochlorogenic acid
CAS:Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.Formula:C16H18O9Purity:99.12% - 99.73%Color and Shape:White PowderMolecular weight:354.31ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formula:C21H25ClN4O2Purity:100%Color and Shape:SolidMolecular weight:400.9Ref: TM-T10237
1mg66.00€5mg144.00€10mg227.00€25mg375.00€50mg540.00€100mg777.00€500mg1,549.00€1mL*10mM (DMSO)159.00€IRAK inhibitor 6
CAS:IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM).Formula:C20H20N4O3SPurity:99.44%Color and Shape:SolidMolecular weight:396.46NT-0249
CAS:NT-0249 is an inflammatory vesicle NLRP3 inhibitor with anti-inflammatory activity that reverses high-fat diet-induced obesity.Formula:C22H28N5NaO4SColor and Shape:SoildMolecular weight:481.5411-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Formula:C30H46O4Purity:99.68%Color and Shape:SolidMolecular weight:470.68Ref: TM-TN1182
1mg60.00€5mg137.00€10mg210.00€25mg356.00€50mg525.00€100mg750.00€1mL*10mM (DMSO)140.00€RIPA-56
CAS:RIPA-56 is an inhibitor of RIP1Formula:C13H19NO2Purity:99.53% - 99.95%Color and Shape:SolidMolecular weight:221.3Ref: TM-T7795
5mg38.00€10mg52.00€25mg94.00€50mg136.00€100mg213.00€200mg316.00€500mg532.00€1mL*10mM (DMSO)55.00€oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Formula:C36H58O5Color and Shape:SolidMolecular weight:570.84N,N-Dimethylacetamide
CAS:N,N-Dimethylacetamide (DMAc) is a drug excipient with anti-inflammatory activity, acting through the inhibition of the NF-κB signaling pathway.Formula:C4H9NOPurity:99.13%Color and Shape:Colourless LiquidMolecular weight:87.12Hentriacontane
CAS:Hentriacontane is a natural product with various pharmacological effects including anti-inflammatory, antitumor, and antimicrobial activities.Formula:C31H64Purity:95.85%Color and Shape:SolidMolecular weight:436.84NBD peptide
CAS:NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.Formula:C62H88N14O20Color and Shape:SolidMolecular weight:1349.44Ginsenoside Rd
CAS:Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purity:99.13% - 99.8%Color and Shape:SolidMolecular weight:947.15Ref: TM-T2878
1mg39.00€5mg81.00€10mg127.00€25mg205.00€50mg304.00€100mg455.00€500mg998.00€1mL*10mM (DMSO)131.00€IRAK4-IN-24
IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability.Formula:C19H19N5O3Purity:98%Color and Shape:SolidMolecular weight:365.39Embelin
CAS:Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).Formula:C17H26O4Purity:97.07% - 99.88%Color and Shape:SolidMolecular weight:294.39RIPK1-IN-27
RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.Formula:C27H28N4O3Color and Shape:SolidMolecular weight:456.54Schisantherin A
CAS:Schisantherin A, a lignan from Schisandra fruit, is used as an antitussive, tonic, and sedative.Formula:C30H32O9Purity:98% - 99.96%Color and Shape:SolidMolecular weight:536.57Cudraflavone B
CAS:Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells andFormula:C25H24O6Purity:98%Color and Shape:SolidMolecular weight:420.45Sabialimon P
CAS:Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.Formula:C31H50O4Color and Shape:SolidMolecular weight:486.73BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formula:C27H30F3N9OPurity:99.62%Color and Shape:SolidMolecular weight:553.58Ref: TM-T10477
1mg172.00€5mg354.00€10mg567.00€25mg905.00€50mg1,225.00€100mg1,644.00€1mL*10mM (DMSO)430.00€SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Color and Shape:Odour SolidGLPG2534
CAS:GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.Formula:C21H24N6O4Purity:98.89% - 99.61%Color and Shape:SolidMolecular weight:424.45GSK3145095
CAS:GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.Formula:C20H17F2N5O2Purity:99.50%Color and Shape:SolidMolecular weight:397.38Ref: TM-T15437
1mg96.00€5mg246.00€10mg344.00€25mg553.00€50mg727.00€100mg938.00€1mL*10mM (DMSO)240.00€SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Formula:C9H8N2OS2Purity:100% - 99.88%Color and Shape:SolidMolecular weight:224.3Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formula:C42H70O12Purity:98% - 98.07%Color and Shape:SolidMolecular weight:767Ref: TM-T6S1487
1mg113.00€5mg265.00€10mg426.00€25mg702.00€50mg938.00€100mg1,320.00€1mL*10mM (DMSO)360.00€Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formula:C7H5NaO3Purity:99.36% - 99.77%Color and Shape:White Solid AmorphousMolecular weight:160.11Aconine
CAS:1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.Formula:C25H41NO9Purity:99.43% - 99.61%Color and Shape:SolidMolecular weight:499.59AS-2444697
CAS:AS-2444697, an IRAK-4 inhibitor (C50=21 nM), offers renal protection via anti-inflammatory effects on human and rat IRAK-4.Formula:C19H21ClN6O4Purity:97.43%Color and Shape:SolidMolecular weight:432.86Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formula:C14H23ClN2OPurity:99.81% - 99.92%Color and Shape:White Crystal PowderMolecular weight:270.798WEHI-345
CAS:WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.Formula:C22H23N7OPurity:100%Color and Shape:SolidMolecular weight:401.46Cpd27
CAS:Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.Formula:C20H13F4N5O2Purity:98.89%Color and Shape:SolidMolecular weight:431.34TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formula:C22H26N2O2Purity:99.85% - 99.98%Color and Shape:White Crystalline SolidMolecular weight:350.45IRAK inhibitor 2
CAS:IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.Formula:C17H14N4O2Purity:97.62% - 99.26%Color and Shape:SolidMolecular weight:306.32Ref: TM-T7368
1mg86.00€5mg180.00€10mg259.00€25mg455.00€50mg655.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)188.00€LTβR-IN-1
CAS:LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.Formula:C18H16N4O2Purity:99.09%Color and Shape:SolidMolecular weight:320.35Ref: TM-T11886
1mg35.00€5mg80.00€10mg116.00€25mg220.00€50mg328.00€100mg469.00€500mg938.00€1mL*10mM (DMSO)87.00€yangonin
CAS:Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.Formula:C15H14O4Purity:98.82% - 99.55%Color and Shape:Pale Yellow PowderMolecular weight:258.27Ref: TM-T3S0738
1mg70.00€5mg135.00€10mg207.00€25mg349.00€50mg515.00€100mg735.00€1mL*10mM (DMSO)177.00€Sulfasalazine
CAS:Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Formula:C18H14N4O5SPurity:98.00% - 99.28%Color and Shape:Minute Brownish-Yellow CrystalsMolecular weight:398.39Tryptanthrin
CAS:Tryptanthrin is a natural DNA gyrase inhibitor.Formula:C15H8N2O2Purity:99.64% - 99.94%Color and Shape:SolidMolecular weight:248.24GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formula:C28H19FN2O4Purity:99.72%Color and Shape:SolidMolecular weight:466.46Ref: TM-T25465
2mg38.00€5mg58.00€10mg92.00€25mg170.00€50mg259.00€100mg378.00€200mg548.00€1mL*10mM (DMSO)60.00€Dimethoxycurcumin
CAS:Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Formula:C23H24O6Purity:96.05%Color and Shape:SolidMolecular weight:396.43Ref: TM-T19853
5mg50.00€10mg81.00€25mg140.00€50mg239.00€100mg349.00€200mg497.00€1mL*10mM (DMSO)56.00€BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Formula:C14H17N5Purity:98.74% - 99.74%Color and Shape:SolidMolecular weight:255.32Licochalcone D
CAS:Licochalcone D may treat melanoma and heart injury, halt cell spread, and reduce inflammation and allergies.Formula:C21H22O5Purity:99.03% - 99.9%Color and Shape:SolidMolecular weight:354.4SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Formula:C10H5ClN4O5SPurity:99.64% - 99.64%Color and Shape:SolidMolecular weight:328.69Ref: TM-T22115
5mg47.00€10mg74.00€25mg135.00€50mg188.00€100mg283.00€200mg411.00€1mL*10mM (DMSO)50.00€Picroside II
CAS:Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides.Formula:C23H28O13Purity:98% - 99.83%Color and Shape:SolidMolecular weight:512.46NF-κB-IN-13
CAS:NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1Formula:C20H20O5Purity:98%Color and Shape:SolidMolecular weight:340.37
