NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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Tenuigenin
CAS:Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.Formula:C30H45ClO6Purity:98.9% - 99.53%Color and Shape:SolidMolecular weight:537.13Ref: TM-T3907
2mg37.00€5mg52.00€10mg77.00€25mg111.00€50mg160.00€100mg227.00€200mg335.00€1mL*10mM (DMSO)66.00€RIPK1-IN-7
CAS:RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.Formula:C25H22F3N5O2Purity:98.02% - 98.18%Color and Shape:SolidMolecular weight:481.47Ref: TM-T12731
1mg92.00€5mg216.00€10mg329.00€25mg512.00€50mg707.00€100mg944.00€1mL*10mM (DMSO)233.00€Sciadopitysin
CAS:Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.Formula:C33H24O10Purity:98.14% - 99.17%Color and Shape:SolidMolecular weight:580.54Ref: TM-T5S2129
1mg52.00€5mg95.00€10mg162.00€25mg304.00€50mg455.00€100mg653.00€500mg1,349.00€1mL*10mM (DMSO)130.00€Sarsasapogenin
CAS:Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.Formula:C27H44O3Purity:90% - 99.73%Color and Shape:White Or Off-Withe PowderMolecular weight:416.64MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formula:C19H15ClN4O2Purity:98.92%Color and Shape:SolidMolecular weight:366.8Ref: TM-TQ0306
1mg49.00€2mg70.00€5mg96.00€10mg160.00€25mg329.00€50mg567.00€100mg777.00€1mL*10mM (DMSO)116.00€DRI-C21045
CAS:Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Formula:C32H24N2O7SPurity:98.10%Color and Shape:SolidMolecular weight:580.61IQ-1S free acid
CAS:IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formula:C15H9N3OPurity:97.92% - 99.05%Color and Shape:SolidMolecular weight:247.25Ref: TM-T3627
5mg47.00€10mg52.00€25mg96.00€50mg169.00€100mg304.00€200mg454.00€500mg733.00€1mL*10mM (DMSO)50.00€NF-κΒ activator 1
CAS:NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Formula:C16H11FN2O2SPurity:98.85%Color and Shape:SolidMolecular weight:314.33Ref: TM-T39965
1mg95.00€5mg202.00€10mg329.00€25mg560.00€50mg800.00€100mg1,103.00€500mg2,213.00€1mL*10mM (DMSO)224.00€Dehydrocostus Lactone
CAS:Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Formula:C15H18O2Purity:99.86% - 99.98%Color and Shape:SolidMolecular weight:230.3Theophylline monohydrate
CAS:Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormula:C7H8N4O2·H2OPurity:99.78%Color and Shape:SolidMolecular weight:198.18Chelidonic acid
CAS:Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.Formula:C7H4O6Purity:99.03%Color and Shape:SolidMolecular weight:184.1Cyclo(his-pro)
CAS:Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.Formula:C11H14N4O2Purity:99.87%Color and Shape:SolidMolecular weight:234.25Tripeptide-41
CAS:Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formula:C29H30N4O5Purity:98%Color and Shape:SolidMolecular weight:514.57Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.Formula:C20H21F3N4O4SPurity:98.48%Color and Shape:SolidMolecular weight:470.47Ref: TM-T37076
1mg43.00€5mg96.00€10mg135.00€25mg220.00€50mg323.00€100mg450.00€500mgTo inquire1mL*10mM (DMSO)96.00€NF-κB-IN-11
CAS:NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Formula:C19H18O5Purity:98%Color and Shape:SolidMolecular weight:326.34Kamebakaurin
CAS:Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Formula:C20H30O5Purity:98.05%Color and Shape:SolidMolecular weight:350.45NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).Formula:C19H18N3O2PSPurity:99.41%Color and Shape:SolidMolecular weight:383.4Prostratin
CAS:Prostratin is an orally active PKC activator,an NF-κB activator and activates HIV expression. Induces KRAS phosphorylation and inhibits tumor growth.Formula:C22H30O6Purity:98%Color and Shape:White To Off-White PowderMolecular weight:390.47Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormula:C21H18O11Purity:90.08% - 99.25%Color and Shape:Yellow PowderMolecular weight:446.36CAFESTOL
CAS:Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.Formula:C20H28O3Purity:97.06% - 99.08%Color and Shape:SolidMolecular weight:316.43NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Formula:C13H8F2INO2Purity:99.64%Color and Shape:SolidMolecular weight:375.11Cyclo(L-Pro-L-Val)
CAS:Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.Formula:C10H16N2O2Purity:98.18%Color and Shape:SolidMolecular weight:196.25CDDO-dhTFEA
CAS:CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formula:C33H45F3N2O3Purity:95.61% - 99.59%Color and Shape:SolidMolecular weight:574.72Ref: TM-T13604
1mg70.00€2mg92.00€5mg153.00€10mg255.00€25mg512.00€50mg738.00€100mg1,035.00€500mg2,062.00€1mL*10mM (DMSO)187.00€Rucaparib
CAS:Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Formula:C19H18FN3OPurity:98.37% - 99.80%Color and Shape:SolidMolecular weight:323.36Ref: TM-T4463
2mg48.00€5mg73.00€10mg115.00€25mg173.00€50mg235.00€100mg364.00€200mg540.00€500mg869.00€1mL*10mM (DMSO)81.00€SC75741
CAS:SC75741 is a potent P65 inhibitor with IC50 of 200 nMFormula:C29H23N7O2S2Purity:99.44% - 99.82%Color and Shape:SolidMolecular weight:565.67Edecesertib
CAS:Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.Formula:C22H22FN7O2Purity:98.84%Color and Shape:SolidMolecular weight:435.45ANTHRAQUINONE-2-CARBOXYLIC ACID
CAS:Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role ofFormula:C15H8O4Purity:99.08% - 99.83%Color and Shape:SolidMolecular weight:252.22Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purity:95.32% - 98.46%Color and Shape:SolidMolecular weight:505.56Muscone
CAS:Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Formula:C16H30OPurity:99.28%Color and Shape:Colourless Liquid LiquidMolecular weight:238.41TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formula:C27H37N7O2Purity:99.91%Color and Shape:SolidMolecular weight:491.63Zingerone
CAS:Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale with potent anti-inflammatory, antidiabetic and anti-tumor properties.Formula:C11H14O3Purity:99.38% - 99.85%Color and Shape:Clear Slightly Yellow LiquidMolecular weight:194.23PROTAC IRAK4 degrader-8
CAS:PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].Formula:C43H50ClF2N11O5Purity:98%Color and Shape:SolidMolecular weight:874.38WAY-169916
CAS:WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Formula:C17H13F3N2O2Purity:98.63% - 98.64%Color and Shape:SolidMolecular weight:334.29Ref: TM-T8981
2mg42.00€5mg64.00€10mg97.00€25mg197.00€50mg329.00€100mg475.00€200mg655.00€1mL*10mM (DMSO)94.00€Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formula:C23H17N3OS3Purity:98.02% - 98.31%Color and Shape:SolidMolecular weight:447.6Malachite green oxalate
CAS:Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Formula:C23H25N2·C2HO4C2H2O4Color and Shape:Dark Green Crystals With A Metallic LusterMolecular weight:463.51IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formula:C15H8ClF6NO2Purity:99.56% - 99.71%Color and Shape:SolidMolecular weight:383.67Ref: TM-T6141
2mg48.00€5mg66.00€10mg92.00€25mg163.00€50mg221.00€100mg310.00€500mg753.00€1mL*10mM (DMSO)69.00€RIP2 Kinase Inhibitor 3
CAS:RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.Formula:C19H24N4O3SPurity:98.28% - 98.35%Color and Shape:SolidMolecular weight:388.48Benzoyloxypaeoniflorin
CAS:Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Formula:C30H32O13Purity:97.64% - 98.7%Color and Shape:SolidMolecular weight:600.57Ref: TM-T4S1658
1mg127.00€5mg298.00€10mg432.00€25mg697.00€50mg938.00€100mg1,293.00€1mL*10mM (DMSO)378.00€GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53Ref: TM-T15558
1mg73.00€5mg153.00€10mg255.00€25mg535.00€50mg910.00€100mg1,216.00€1mL*10mM (DMSO)340.00€RIPK1-IN-16
CAS:RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formula:C20H19N5O2SPurity:98%Color and Shape:SolidMolecular weight:393.46IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formula:C22H25F3N4O3Purity:97.32%Color and Shape:SolidMolecular weight:450.45Asatone
CAS:Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formula:C24H32O8Purity:99.84% - 99.92%Color and Shape:SolidMolecular weight:448.51Ref: TM-T10383
1mg88.00€5mg202.00€10mg303.00€25mg509.00€50mg725.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)198.00€BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formula:C14H18ClN5Purity:99.13%Color and Shape:SolidMolecular weight:291.78Ref: TM-T8542
1mg40.00€2mg52.00€5mg87.00€10mg126.00€25mg225.00€50mg376.00€100mg563.00€1mL*10mM (DMSO)55.00€Velutin
CAS:Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well asFormula:C17H14O6Purity:99.69%Color and Shape:SolidMolecular weight:314.29AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Formula:C21H23N5O4SPurity:98.98% - 99.17%Color and Shape:SolidMolecular weight:441.5Ref: TM-T6771
1mg52.00€2mg70.00€5mg103.00€10mg160.00€25mg311.00€50mg502.00€100mg805.00€500mg1,605.00€1mL*10mM (DMSO)114.00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45Ref: TM-T9010
1mg40.00€5mg96.00€10mg135.00€25mg226.00€50mg320.00€100mg434.00€200mg602.00€1mL*10mM (DMSO)131.00€PROTAC IRAK4 degrader-12
CAS:PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Formula:C46H50ClF2N11O6Color and Shape:SolidMolecular weight:926.41BI-69A11
CAS:BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.Formula:C25H16ClN3O2Purity:96.97%Color and Shape:SolidMolecular weight:425.87Ref: TM-T25150
1mg46.00€2mg57.00€5mg82.00€10mg96.00€25mg180.00€50mg259.00€100mg369.00€1mL*10mM (DMSO)93.00€
